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Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition.
Shattuck-Brandt RL, Chen SC, Murray E, Johnson CA, Crandall H, O'Neal JF, Al-Rohil RN, Nebhan CA, Bharti V, Dahlman KB, Ayers GD, Yan C, Kelley MC, Kauffmann RM, Hooks M, Grau A, Johnson DB, Vilgelm AE, Richmond A
(2020) Clin Cancer Res 26: 3803-3818
MeSH Terms: Adult, Aged, Animals, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Female, Humans, MAP Kinase Signaling System, Male, Melanoma, Mice, Middle Aged, Mitogen-Activated Protein Kinase Kinases, Mutation, Protein Kinase Inhibitors, Proteolysis, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-mdm2, Skin Neoplasms, Tumor Suppressor Protein p53, Ubiquitination, Xenograft Model Antitumor Assays
Added May 4, 2020
0 Communities
1 Members
0 Resources
22 MeSH Terms
An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report.
Sherry AD, Bezzerides M, Khattab MH, Luo G, Ancell KK, Kirschner AN
(2020) Strahlenther Onkol 196: 664-670
MeSH Terms: Aged, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, Autoimmune Diseases of the Nervous System, Axilla, Carboplatin, Carcinoma, Merkel Cell, Combined Modality Therapy, Deglutition Disorders, Etoposide, Fatal Outcome, Fingers, Hallucinations, Humans, Lymphatic Metastasis, Male, Neuralgia, Palliative Care, Paraneoplastic Syndromes, Nervous System, Parenteral Nutrition, Total, Pneumonia, Aspiration, Positron Emission Tomography Computed Tomography, Radioimmunotherapy, Radiotherapy, High-Energy, Radiotherapy, Intensity-Modulated, Skin Neoplasms
Added March 3, 2020
0 Communities
1 Members
0 Resources
27 MeSH Terms
Diffuse Primary Cutaneous Anaplastic Large Cell Lymphoma Treated by Rotational Total Skin Electron Beam Radiotherapy with Custom Shielding: Case Report.
Sherry AD, Ding GX, Kirschner AN
(2019) J Med Imaging Radiat Sci 50: 454-459
MeSH Terms: Aged, Humans, Lymphoma, Primary Cutaneous Anaplastic Large Cell, Male, Radiation Protection, Radiometry, Radiotherapy, Skin Neoplasms
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Intraocular involvement of mycosis fungoides associated with immunophenotypic switch from CD4 to CD8.
Braue JA, Daniels AB, Zwerner JP, Kim SJ, Zic JA
(2018) Blood 131: 932-935
MeSH Terms: Aged, CD4 Antigens, CD8 Antigens, Eye Diseases, Female, Humans, Immunophenotyping, Middle Aged, Mycosis Fungoides, Prognosis, Skin Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Integrative genetic analysis suggests that skin color modifies the genetic architecture of melanoma.
Hulur I, Skol AD, Gamazon ER, Cox NJ, Onel K
(2017) PLoS One 12: e0185730
MeSH Terms: European Continental Ancestry Group, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genome-Wide Association Study, Humans, Melanoma, Models, Genetic, Polymorphism, Single Nucleotide, Skin Neoplasms, Skin Pigmentation
Added October 27, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Quantitative Mass Spectrometry Analysis of PD-L1 Protein Expression, -glycosylation and Expression Stoichiometry with PD-1 and PD-L2 in Human Melanoma.
Morales-Betanzos CA, Lee H, Gonzalez Ericsson PI, Balko JM, Johnson DB, Zimmerman LJ, Liebler DC
(2017) Mol Cell Proteomics 16: 1705-1717
MeSH Terms: Acetylglucosamine, Adult, Aged, B7-H1 Antigen, Biopsy, Cohort Studies, Female, Glycosylation, Humans, Male, Mannose, Mass Spectrometry, Melanoma, Middle Aged, Polysaccharides, Programmed Cell Death 1 Ligand 2 Protein, Programmed Cell Death 1 Receptor, Protein Processing, Post-Translational, Skin Neoplasms, T-Lymphocytes
Added March 14, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Scalp-sparing total skin electron therapy in mycosis fungoides: Case report featuring a technique without lead.
Patel CG, Ding G, Kirschner A
(2017) Pract Radiat Oncol 7: 400-402
MeSH Terms: Electrons, Humans, Male, Middle Aged, Mycosis Fungoides, Scalp, Skin Neoplasms, Treatment Outcome
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
The major miR-31 target genes STK40 and LATS2 and their implications in the regulation of keratinocyte growth and hair differentiation.
Luan L, Shi J, Yu Z, Andl T
(2017) Exp Dermatol 26: 497-504
MeSH Terms: 3' Untranslated Regions, Adaptor Proteins, Signal Transducing, Animals, Apoptosis, Carcinoma, Basal Cell, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cell Survival, Hair Follicle, Homeodomain Proteins, Humans, Intracellular Signaling Peptides and Proteins, Keratinocytes, Mice, Mice, Transgenic, MicroRNAs, Protein-Serine-Threonine Kinases, Skin, Skin Neoplasms, Trans-Activators, Transcription Factors, Tumor Suppressor Proteins
Added June 21, 2017
1 Communities
0 Members
0 Resources
23 MeSH Terms
Mass Spectrometry Imaging Can Distinguish on a Proteomic Level Between Proliferative Nodules Within a Benign Congenital Nevus and Malignant Melanoma.
Lazova R, Yang Z, El Habr C, Lim Y, Choate KA, Seeley EH, Caprioli RM, Yangqun L
(2017) Am J Dermatopathol 39: 689-695
MeSH Terms: Diagnosis, Differential, Female, Humans, Infant, Mass Spectrometry, Melanoma, Nevus, Pigmented, Skin Neoplasms
Added April 17, 2017
1 Communities
1 Members
0 Resources
8 MeSH Terms
Imaging mass spectrometry assists in the classification of diagnostically challenging atypical Spitzoid neoplasms.
Lazova R, Seeley EH, Kutzner H, Scolyer RA, Scott G, Cerroni L, Fried I, Kozovska ME, Rosenberg AS, Prieto VG, Shehata BM, Durham MM, Henry G, Rodriguez-Peralto JL, Riveiro-Falkenbach E, Schaefer JT, Danialan R, Fraitag S, Vollenweider-Roten S, Sepehr A, Sangueza M, Hijazi N, Corredoira Y, Kowal R, Harris OM, Bravo F, Boyd AS, Gueorguieva R, Caprioli RM
(2016) J Am Acad Dermatol 75: 1176-1186.e4
MeSH Terms: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Lymphatic Metastasis, Male, Mass Spectrometry, Melanoma, Middle Aged, Neoplasm Recurrence, Local, Nevus, Epithelioid and Spindle Cell, Proteins, Retrospective Studies, Risk Assessment, Sentinel Lymph Node Biopsy, Skin Neoplasms, Treatment Outcome, Tumor Burden, Young Adult
Added April 17, 2017
1 Communities
1 Members
0 Resources
25 MeSH Terms