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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer's Disease Genetics Consortium
(2016) Neurobiol Aging 38: 141-150
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Alzheimer Disease, Cadherins, Calcium Channels, L-Type, Datasets as Topic, Disease Progression, Epistasis, Genetic, Female, Genetic Association Studies, Humans, Male, Models, Genetic, Phosphatidylethanolamine Binding Protein, Polymorphism, Single Nucleotide, Receptors, Adrenergic, alpha-1, Receptors, N-Methyl-D-Aspartate, Risk, Ryanodine Receptor Calcium Release Channel, Saposins, Sirtuin 1
Added April 10, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver.
Kurtz CL, Fannin EE, Toth CL, Pearson DS, Vickers KC, Sethupathy P
(2015) Sci Rep 5: 12911
MeSH Terms: Animals, Cholesterol, Dyslipidemias, Female, Lipogenesis, Liver, Mice, MicroRNAs, Receptors, Aryl Hydrocarbon, Sirtuin 1
Added April 25, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.
Chiang C, Ihrie RA
(2014) Cancer Cell 26: 773-774
MeSH Terms: Animals, DNA-Binding Proteins, Humans, Medulloblastoma, Neurogenesis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-6, Repressor Proteins, Signal Transduction, Sirtuin 1
Added January 26, 2015
1 Communities
2 Members
0 Resources
10 MeSH Terms
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
(2013) Cell 155: 1624-38
MeSH Terms: AMP-Activated Protein Kinases, Aging, Animals, Cell Nucleus, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Mitochondria, Muscle, Skeletal, NAD, Oxidative Phosphorylation, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Reactive Oxygen Species, Sirtuin 1, Transcription Factors
Added March 4, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.
Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F
(2013) J Bone Miner Res 28: 960-9
MeSH Terms: Acetylation, Aging, Animals, Bone Remodeling, Bone and Bones, Gene Deletion, Gene Knockdown Techniques, I-kappa B Proteins, Mice, NF-KappaB Inhibitor alpha, NF-kappa B, Organ Size, Organ Specificity, Osteoblasts, Osteoclasts, Signal Transduction, Sirtuin 1
Added November 14, 2013
2 Communities
6 Members
0 Resources
17 MeSH Terms
Age-related susceptibility to apoptosis in human retinal pigment epithelial cells is triggered by disruption of p53-Mdm2 association.
Bhattacharya S, Chaum E, Johnson DA, Johnson LR
(2012) Invest Ophthalmol Vis Sci 53: 8350-66
MeSH Terms: Acetylation, Adult, Aged, Aged, 80 and over, Aging, Apoptosis, Apoptosis Regulatory Proteins, Benzamides, Blotting, Western, Caspase 3, Cell Proliferation, Cells, Cultured, DNA Fragmentation, Disease Susceptibility, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Indirect, Humans, Imidazoles, In Situ Nick-End Labeling, Middle Aged, Naphthols, Phosphorylation, Piperazines, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-mdm2, RNA, Small Interfering, Retinal Pigment Epithelium, Sirtuin 1, Sirtuin 2, Tumor Suppressor Protein p53
Added June 11, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA
(2012) Cell Metab 15: 675-90
MeSH Terms: Animals, Cells, Cultured, Enzyme Activation, Hepatocytes, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Muscle, Skeletal, NAD, Protein Kinases, Resveratrol, Signal Transduction, Sirtuin 1, Stilbenes
Added April 25, 2013
0 Communities
0 Members
1 Resources
15 MeSH Terms
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.
Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP
(2012) Biochim Biophys Acta 1822: 185-95
MeSH Terms: AMP-Activated Protein Kinases, Animals, Berberine, Cell Line, Diet, High-Fat, Glucose, Hormones, Hyperglycemia, Insulin Resistance, Male, Mice, Mitochondria, Mitochondria, Muscle, Muscle, Skeletal, Myoblasts, NAD, Obesity, Organelle Biogenesis, Phosphorylation, Rats, Rats, Sprague-Dawley, Sirtuin 1
Added April 25, 2013
0 Communities
0 Members
1 Resources
22 MeSH Terms
SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2.
Hirschey MD, Shimazu T, Capra JA, Pollard KS, Verdin E
(2011) Aging (Albany NY) 3: 635-42
MeSH Terms: Acetate-CoA Ligase, Acetylation, Animals, Evolution, Molecular, Humans, Hydroxymethylglutaryl-CoA Synthase, Isoenzymes, Phylogeny, Sirtuin 1, Sirtuin 3
Added April 18, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Sirt1 activation protects the mouse renal medulla from oxidative injury.
He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM
(2010) J Clin Invest 120: 1056-68
MeSH Terms: Animals, Apoptosis, Cells, Cultured, Cyclooxygenase 2, Fibrosis, Heterocyclic Compounds, 4 or More Rings, Kidney Medulla, Male, Mice, Mice, Inbred C57BL, Oxidative Stress, Resveratrol, Sirtuin 1, Stilbenes, Ureteral Obstruction
Added December 10, 2013
1 Communities
4 Members
0 Resources
15 MeSH Terms