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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 62

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Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC
(2020) JCI Insight 5:
MeSH Terms: Animals, Calcineurin, Diabetes Mellitus, Graft Rejection, Humans, Immunosuppressive Agents, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Islets of Langerhans Transplantation, Male, Mice, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases, Tacrolimus
Added March 29, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies.
Pinto JA, Rolfo C, Raez LE, Prado A, Araujo JM, Bravo L, Fajardo W, Morante ZD, Aguilar A, Neciosup SP, Mas LA, Bretel D, Balko JM, Gomez HL
(2017) Sci Rep 7: 1526
MeSH Terms: Biomarkers, Tumor, Computer Simulation, DNA Damage, Databases as Topic, Humans, Neoplasms, Phosphatidylinositol 3-Kinases, Prognosis, Signal Transduction, Sirolimus, Survival Analysis, TOR Serine-Threonine Kinases, Transcription Factors, Treatment Outcome
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization.
Sengupta P, Satpute-Krishnan P, Seo AY, Burnette DT, Patterson GH, Lippincott-Schwartz J
(2015) Proc Natl Acad Sci U S A 112: E6752-61
MeSH Terms: Animals, COS Cells, Chlorocebus aethiops, Endoplasmic Reticulum, Golgi Apparatus, HeLa Cells, Humans, Mitosis, Phospholipases A2, Calcium-Independent, Sirolimus, Tacrolimus Binding Protein 1A, Tacrolimus Binding Proteins, rab GTP-Binding Proteins
Added August 25, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.
Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW
(2016) Aging Cell 15: 28-38
MeSH Terms: Animals, Blood Glucose, Cell Proliferation, Glucose Intolerance, Homeostasis, Immune System, Insulin-Secreting Cells, Mice, Inbred C57BL, Signal Transduction, Sirolimus
Added August 2, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Unleashing rapamycin in fibrosis.
Hillel AT, Gelbard A
(2015) Oncotarget 6: 15722-3
MeSH Terms: Fibrosis, Humans, Sirolimus
Added January 25, 2017
0 Communities
1 Members
0 Resources
3 MeSH Terms
Phosphatidylinositol 3-kinase signaling determines kidney size.
Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC
(2015) J Clin Invest 125: 2429-44
MeSH Terms: Animals, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Immunosuppressive Agents, Kidney, Kidney Diseases, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred DBA, Mice, Knockout, Multiprotein Complexes, Organ Size, Phosphatidylinositol 3-Kinases, Phosphorylation, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases
Added August 5, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
An unusual cause of respiratory failure in a 25-year-old heart and lung transplant recipient.
Narotzky S, Kennedy CC, Maldonado F
(2015) Chest 147: e185-e188
MeSH Terms: Adult, Female, Heart-Lung Transplantation, Humans, Immunosuppressive Agents, Postoperative Complications, Pulmonary Alveolar Proteinosis, Respiratory Insufficiency, Sirolimus
Added July 28, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
He K, Zheng X, Li M, Zhang L, Yu J
(2016) Oncogene 35: 148-57
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Apoptosis, Cell Cycle Proteins, Cell Line, Tumor, Colonic Neoplasms, Everolimus, Female, Humans, Mice, Nude, Phosphoproteins, Phosphorylation, Protein Kinase Inhibitors, Receptors, TNF-Related Apoptosis-Inducing Ligand, Sirolimus, TOR Serine-Threonine Kinases, Transcription Factor CHOP, Xenograft Model Antitumor Assays
Added July 28, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
FDG-PET as a predictive biomarker for therapy with everolimus in metastatic renal cell cancer.
Chen JL, Appelbaum DE, Kocherginsky M, Cowey CL, Rathmell WK, McDermott DF, Stadler WM
(2013) Cancer Med 2: 545-52
MeSH Terms: Adult, Aged, Antineoplastic Agents, Biomarkers, Carcinoma, Renal Cell, Everolimus, Female, Fluorodeoxyglucose F18, Humans, Kidney Neoplasms, Male, Middle Aged, Neoplasm Metastasis, Positron-Emission Tomography, Sirolimus, Treatment Outcome, Tumor Burden
Added October 17, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes.
Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A
(2013) J Clin Endocrinol Metab 98: E1780-5
MeSH Terms: Adult, Diabetes Mellitus, Type 1, Female, Glucose Clamp Technique, Glycated Hemoglobin A, Graft Rejection, Humans, Immunosuppressive Agents, Insulin, Insulin Resistance, Islets of Langerhans Transplantation, Liver, Male, Middle Aged, Muscle, Skeletal, Sirolimus, Tacrolimus
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms