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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G
(2020) Diabetes 69: 1219-1231
MeSH Terms: Aging, Animals, Basic Helix-Loop-Helix Transcription Factors, Calcium, Cell Survival, Diabetes Mellitus, Female, Gene Expression Regulation, Developmental, Homeostasis, Insulin-Secreting Cells, Male, Mice, Mice, Knockout, Nerve Tissue Proteins, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex
Added April 7, 2020
2 Communities
3 Members
0 Resources
16 MeSH Terms
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation.
Chang S, Collins PL, Aune TM
(2008) J Immunol 181: 8372-81
MeSH Terms: Acetylation, Animals, Cell Differentiation, Cell Proliferation, Cells, Cultured, Histone Acetyltransferases, Histone Deacetylase Inhibitors, Histone Deacetylases, Histones, Interferon-gamma, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout, Protein Transport, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, T-Box Domain Proteins, Th1 Cells
Added December 10, 2013
0 Communities
1 Members
0 Resources
19 MeSH Terms
Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors.
Xu Z, Meng X, Cai Y, Koury MJ, Brandt SJ
(2006) Biochem J 399: 297-304
MeSH Terms: Acetylation, Animals, Cell Differentiation, Chromosomal Proteins, Non-Histone, DNA, DNA Helicases, Erythroid Precursor Cells, Histone Deacetylase 2, Histone Deacetylases, Histones, Mice, Multiprotein Complexes, Nuclear Proteins, Promoter Regions, Genetic, Protein Binding, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors, Transcription, Genetic, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.
Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW
(2005) Mol Cell Biol 25: 9576-85
MeSH Terms: Animals, Cell Line, Cell Lineage, Chlorocebus aethiops, Enteroendocrine Cells, Goblet Cells, Histone Deacetylases, Humans, Intestine, Small, Mice, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Paneth Cells, Phosphoproteins, Protein Binding, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription, Genetic
Added August 13, 2010
2 Communities
4 Members
0 Resources
18 MeSH Terms
T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site.
Tong Y, Aune T, Boothby M
(2005) Proc Natl Acad Sci U S A 102: 2034-9
MeSH Terms: Binding Sites, CCAAT-Enhancer-Binding Proteins, Chromosomal Proteins, Non-Histone, DNA Methylation, DNA-Binding Proteins, Epigenesis, Genetic, Humans, Interferon-gamma, Jurkat Cells, Methyl-CpG-Binding Protein 2, Promoter Regions, Genetic, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, T-Box Domain Proteins, Transcription Factors, Transcriptional Activation
Added December 10, 2013
0 Communities
2 Members
0 Resources
16 MeSH Terms
ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW
(2001) Mol Cell Biol 21: 6470-83
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Cell Line, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Histone Deacetylases, Hydroxamic Acids, Leukemia, Myelomonocytic, Acute, Mice, Models, Genetic, Molecular Sequence Data, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Oncogene Proteins, Fusion, Protein Structure, Tertiary, Proto-Oncogene Proteins, RUNX1 Translocation Partner 1 Protein, Repressor Proteins, Sequence Homology, Amino Acid, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors, Transcription, Genetic, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
26 MeSH Terms
TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.
Wang L, Hiebert SW
(2001) Oncogene 20: 3716-25
MeSH Terms: 3T3 Cells, Acetylation, Animals, Binding Sites, COS Cells, Chlorocebus aethiops, Chromosome Mapping, DNA-Binding Proteins, Genes, Tumor Suppressor, Histone Deacetylases, Histones, Matrix Metalloproteinase 3, Mice, Mutagenesis, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Promoter Regions, Genetic, Proto-Oncogene Proteins c-ets, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors
Added June 10, 2010
1 Communities
1 Members
0 Resources
21 MeSH Terms
mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
Huang S, Brandt SJ
(2000) Mol Cell Biol 20: 2248-59
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Humans, Leukemia, Erythroblastic, Acute, Mice, Proto-Oncogene Proteins, Repressor Proteins, Signal Transduction, Sin3 Histone Deacetylase and Corepressor Complex, T-Cell Acute Lymphocytic Leukemia Protein 1, Transcription Factors, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.
Fenrick R, Amann JM, Lutterbach B, Wang L, Westendorf JJ, Downing JR, Hiebert SW
(1999) Mol Cell Biol 19: 6566-74
MeSH Terms: Burkitt Lymphoma, Child, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 21, Core Binding Factor Alpha 2 Subunit, DNA-Binding Proteins, Humans, Models, Genetic, Neoplasm Proteins, Oncogene Proteins, Fusion, Protein Binding, Protein Structure, Tertiary, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, RUNX1 Translocation Partner 1 Protein, Repressor Proteins, Sin3 Histone Deacetylase and Corepressor Complex, Transcription Factors, Translocation, Genetic
Added June 10, 2010
1 Communities
1 Members
0 Resources
19 MeSH Terms