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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 15

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A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition.
Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA
(2016) J Clin Endocrinol Metab 101: 2751-8
MeSH Terms: Adult, CD36 Antigens, Cardiovascular Diseases, Case-Control Studies, Drug Resistance, Endothelium, Vascular, Female, Genetic Predisposition to Disease, Humans, Insulin Resistance, Metabolic Syndrome, Middle Aged, Obesity, Phosphodiesterase 5 Inhibitors, Polymorphism, Single Nucleotide, Sildenafil Citrate, Treatment Outcome, Vasodilation
Added March 14, 2018
0 Communities
1 Members
0 Resources
18 MeSH Terms
Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial.
Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA
(2015) J Clin Endocrinol Metab 100: 4533-40
MeSH Terms: Adult, Albuminuria, Double-Blind Method, Endothelium, Vascular, Female, Fibrinolysis, Glucose, Glucose Clamp Technique, Glucose Tolerance Test, Hemodynamics, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Overweight, Phosphodiesterase 5 Inhibitors, Plasminogen Activator Inhibitor 1, Prediabetic State, Sildenafil Citrate
Added November 30, 2015
0 Communities
3 Members
0 Resources
20 MeSH Terms
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.
Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH
(2011) Diabetes 60: 416-26
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Collagen Type III, Collagen Type V, Diet, Extracellular Matrix, Glucose Clamp Technique, Immunohistochemistry, Insulin, Insulin Resistance, Integrin alpha2beta1, Matrix Metalloproteinase 9, Mice, Mice, Knockout, Muscle, Skeletal, Phosphodiesterase 5 Inhibitors, Piperazines, Purines, Reverse Transcriptase Polymerase Chain Reaction, Sildenafil Citrate, Sulfones
Added February 24, 2014
2 Communities
4 Members
0 Resources
22 MeSH Terms
Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.
Robbins IM, Hemnes AR, Gibbs JS, Christman BW, Howard L, Meehan S, Cabrita I, Gonzalez R, Oyler T, Zhao L, Du RH, Mendes LA, Wilkins MR
(2011) Exp Lung Res 37: 26-34
MeSH Terms: Administration, Oral, Adult, Antihypertensive Agents, Biomarkers, Biopterin, Chemokine CCL2, Drug Therapy, Combination, Endothelin Receptor Antagonists, Exercise Test, Exercise Tolerance, Female, Humans, Hypertension, Pulmonary, London, Male, Middle Aged, Natriuretic Peptide, Brain, Nitric Oxide, Oxidative Stress, Peptide Fragments, Phosphodiesterase 5 Inhibitors, Piperazines, Purines, Recovery of Function, Sildenafil Citrate, Sulfones, Tennessee, Time Factors, Treatment Outcome, Walking
Added February 19, 2015
0 Communities
2 Members
0 Resources
30 MeSH Terms
Sildenafil monotherapy in portopulmonary hypertension can facilitate liver transplantation.
Hemnes AR, Robbins IM
(2009) Liver Transpl 15: 15-9
MeSH Terms: Female, Fibrosis, Hemodynamics, Hepacivirus, Hepatitis C, Humans, Hypertension, Pulmonary, Liver Transplantation, Male, Middle Aged, Piperazines, Purines, Retrospective Studies, Sildenafil Citrate, Sulfones, Time Factors, Treatment Outcome, Vasodilator Agents
Added March 8, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure.
Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I
(2008) Hypertension 51: 1531-6
MeSH Terms: Aged, Blood Pressure, Cross-Over Studies, Enzyme Inhibitors, Female, Humans, Hypertension, Male, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Piperazines, Purines, Shy-Drager Syndrome, Sildenafil Citrate, Sulfones, Supine Position, Vasodilator Agents, omega-N-Methylarginine
Added December 10, 2013
0 Communities
5 Members
0 Resources
19 MeSH Terms
Long-term follow-up after conversion from intravenous epoprostenol to oral therapy with bosentan or sildenafil in 13 patients with pulmonary arterial hypertension.
Johnson RF, Loyd JE, Mullican AL, Fink CA, Robbins IM
(2007) J Heart Lung Transplant 26: 363-9
MeSH Terms: Administration, Inhalation, Administration, Oral, Adult, Aged, Antihypertensive Agents, Blood Pressure, Bosentan, Cardiac Catheterization, Epoprostenol, Female, Follow-Up Studies, Humans, Hypertension, Pulmonary, Iloprost, Injections, Intravenous, Male, Middle Aged, Piperazines, Purines, Retreatment, Retrospective Studies, Sildenafil Citrate, Sulfonamides, Sulfones, Vascular Resistance, Vasodilator Agents
Added March 8, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice.
Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH
(2007) Diabetes 56: 1025-33
MeSH Terms: Animal Feed, Animals, Arginine, Blood Glucose, Blood Pressure, Body Composition, Dietary Fats, Echocardiography, Energy Metabolism, Feeding Behavior, Glucose Clamp Technique, Insulin, Male, Mice, Mice, Inbred C57BL, Mitochondria, Muscle, Piperazines, Purines, Sildenafil Citrate, Sulfones, Vasodilator Agents
Added December 22, 2010
0 Communities
2 Members
0 Resources
21 MeSH Terms
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism.
Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA
(2005) Circ Res 96: 100-9
MeSH Terms: 3',5'-Cyclic-GMP Phosphodiesterases, Adenoviridae, Adrenergic beta-Agonists, Animals, Carbolines, Cyclic GMP, Cyclic GMP-Dependent Protein Kinases, Cyclic Nucleotide Phosphodiesterases, Type 5, Fluorescence Resonance Energy Transfer, Genetic Vectors, Guanylate Cyclase, Isoproterenol, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardial Contraction, NG-Nitroarginine Methyl Ester, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Phosphodiesterase Inhibitors, Piperazines, Purines, Rats, Rats, Sprague-Dawley, Receptors, Adrenergic, beta, Receptors, Cytoplasmic and Nuclear, Recombinant Fusion Proteins, Second Messenger Systems, Sildenafil Citrate, Soluble Guanylyl Cyclase, Sulfones, Tadalafil
Added March 4, 2015
0 Communities
1 Members
0 Resources
34 MeSH Terms
Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil.
Zhu CB, Hewlett WA, Francis SH, Corbin JD, Blakely RD
(2004) Eur J Pharmacol 504: 1-6
MeSH Terms: 3',5'-Cyclic-GMP Phosphodiesterases, Animals, CHO Cells, Cricetinae, Cyclic Nucleotide Phosphodiesterases, Type 5, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Phosphodiesterase Inhibitors, Piperazines, Protein Binding, Purines, Rats, Serotonin, Serotonin Plasma Membrane Transport Proteins, Sildenafil Citrate, Sulfones
Added July 10, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms