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Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.
Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J
(2022) Am J Physiol Regul Integr Comp Physiol 322: R126-R135
MeSH Terms: Acute Lung Injury, Animals, Apoptosis, Caspase 3, Caspase 9, Chemokine CCL2, Cyclooxygenase 2, Disease Models, Animal, Female, Interleukin-10, Lipopolysaccharides, Lung, Male, Mice, Knockout, Pneumonia, Signal Transduction, Tumor Necrosis Factor-alpha
Added February 1, 2022
0 Communities
1 Members
0 Resources
17 MeSH Terms
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A
(2022) JCI Insight 7:
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cells, Cultured, Discoidin Domain Receptor 1, Female, Fibrosis, Gene Expression Regulation, Inflammation, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Phosphorylation, Proto-Oncogene Proteins c-bcr, RNA, STAT3 Transcription Factor, Signal Transduction
Added December 27, 2021
0 Communities
1 Members
0 Resources
18 MeSH Terms
A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes.
Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L
(2021) Genome Med 13: 141
MeSH Terms: Alleles, Alzheimer Disease, Chromosome Mapping, Computational Biology, Databases, Genetic, Gene Expression Profiling, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Models, Biological, Organ Specificity, Polymorphism, Single Nucleotide, Prognosis, Resorcinols, Signal Transduction, Transcriptome
Added October 8, 2021
0 Communities
1 Members
0 Resources
17 MeSH Terms
Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10.
Wu HJ, Mortlock DP, Kuchtey RW, Kuchtey J
(2021) Invest Ophthalmol Vis Sci 62: 26
MeSH Terms: ADAMTS Proteins, Animals, Anterior Chamber, DNA, DNA Mutational Analysis, Disease Models, Animal, Female, Fibrillins, Glaucoma, Open-Angle, Male, Mice, Microfibrils, Mutation, Signal Transduction
Added August 27, 2021
1 Communities
0 Members
0 Resources
14 MeSH Terms
Collagen IV dysfunction in glomerular basement membrane diseases. I. Discovery of a COL4A3 variant in familial Goodpasture's and Alport diseases.
Pokidysheva EN, Seeger H, Pedchenko V, Chetyrkin S, Bergmann C, Abrahamson D, Cui ZW, Delpire E, Fervenza FC, Fidler AL, Fogo AB, Gaspert A, Grohmann M, Gross O, Haddad G, Harris RC, Kashtan C, Kitching AR, Lorenzen JM, McAdoo S, Pusey CD, Segelmark M, Simmons A, Voziyan PA, Wagner T, Wüthrich RP, Zhao MH, Boudko SP, Kistler AD, Hudson BG
(2021) J Biol Chem 296: 100590
MeSH Terms: Animals, Anti-Glomerular Basement Membrane Disease, Collagen Type IV, Mice, Models, Molecular, Mutation, Nephritis, Hereditary, Protein Multimerization, Protein Structure, Quaternary, Signal Transduction
Added September 3, 2021
1 Communities
0 Members
0 Resources
MeSH Terms
The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog.
Kraft G, Coate KC, Smith M, Farmer B, Scott M, Cherrington AD, Edgerton DS
(2021) Diabetes 70: 1292-1302
MeSH Terms: Animals, Blood Glucose, Carbohydrate Metabolism, Dogs, Eating, Female, Glucose, Insulin, Liver, Male, Meals, Signal Transduction
Added November 9, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8 T cells during the primary immune response.
Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH
(2021) Immunity 54: 829-844.e5
MeSH Terms: Animals, CD8-Positive T-Lymphocytes, Cell Proliferation, Female, Glycolysis, Immunologic Memory, Listeria monocytogenes, Listeriosis, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Transgenic, Oxidative Phosphorylation, Receptors, Chimeric Antigen, Signal Transduction, Single-Cell Analysis
Added March 26, 2021
3 Communities
1 Members
0 Resources
16 MeSH Terms
Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.
Hoover AA, Hufnagel DH, Harris W, Bullock K, Glass EB, Liu E, Barham W, Crispens MA, Khabele D, Giorgio TD, Wilson AJ, Yull FE
(2020) BMC Cancer 20: 970
MeSH Terms: Animals, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Female, Humans, Macrophages, Mice, Mice, Transgenic, NF-kappa B, Signal Transduction
Added January 29, 2021
1 Communities
0 Members
0 Resources
11 MeSH Terms
Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress.
Beckman JA, Hu JR, Huang S, Farber-Eger E, Wells QS, Wang TJ, Gerszten RE, Ferguson JF
(2020) Clin Sci (Lond) 134: 2369-2379
MeSH Terms: Brachial Artery, Case-Control Studies, Diabetes Mellitus, Type 2, Endothelium, Vascular, Extremities, Female, Humans, Ischemia, Male, Metabolome, Metabolomics, Middle Aged, Muscle, Skeletal, Phosphorylcholine, Regional Blood Flow, Signal Transduction, Vasodilation
Added September 14, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J
(2020) JCI Insight 5:
MeSH Terms: Animals, Antineoplastic Agents, Breast Neoplasms, Carcinoma, Lewis Lung, Disease Models, Animal, Endothelium, Vascular, Everolimus, Female, Humans, Lymphocytes, Tumor-Infiltrating, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Signal Transduction
Added September 17, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms