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Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer.
Hoover AA, Hufnagel DH, Harris W, Bullock K, Glass EB, Liu E, Barham W, Crispens MA, Khabele D, Giorgio TD, Wilson AJ, Yull FE
(2020) BMC Cancer 20: 970
MeSH Terms: Animals, Cell Line, Tumor, Disease Models, Animal, Disease Progression, Female, Humans, Macrophages, Mice, Mice, Transgenic, NF-kappa B, Signal Transduction
Added January 29, 2021
1 Communities
0 Members
0 Resources
11 MeSH Terms
Metabolomics reveals the impact of Type 2 diabetes on local muscle and vascular responses to ischemic stress.
Beckman JA, Hu JR, Huang S, Farber-Eger E, Wells QS, Wang TJ, Gerszten RE, Ferguson JF
(2020) Clin Sci (Lond) 134: 2369-2379
MeSH Terms: Brachial Artery, Case-Control Studies, Diabetes Mellitus, Type 2, Endothelium, Vascular, Extremities, Female, Humans, Ischemia, Male, Metabolome, Metabolomics, Middle Aged, Muscle, Skeletal, Phosphorylcholine, Regional Blood Flow, Signal Transduction, Vasodilation
Added September 14, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J
(2020) JCI Insight 5:
MeSH Terms: Animals, Antineoplastic Agents, Breast Neoplasms, Carcinoma, Lewis Lung, Disease Models, Animal, Endothelium, Vascular, Everolimus, Female, Humans, Lymphocytes, Tumor-Infiltrating, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Signal Transduction
Added September 17, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Enhanced Expression of Catalase in Mitochondria Modulates NF-κB-Dependent Lung Inflammation through Alteration of Metabolic Activity in Macrophages.
Han W, Fessel JP, Sherrill T, Kocurek EG, Yull FE, Blackwell TS
(2020) J Immunol 205: 1125-1134
MeSH Terms: Animals, Bone Marrow, Catalase, Lung, Macrophages, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, NAD, NF-kappa B, Pneumonia, Reactive Oxygen Species, Signal Transduction
Added July 28, 2020
1 Communities
0 Members
0 Resources
14 MeSH Terms
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC
(2020) Endocrinology 161:
MeSH Terms: Adolescent, Adult, Animals, Benzhydryl Compounds, Cells, Cultured, Female, Glucagon, Glucagon-Secreting Cells, Glucosides, Heterografts, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred NOD, Mice, Transgenic, Middle Aged, Signal Transduction, Species Specificity, Young Adult
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.
Guilherme A, Yenilmez B, Bedard AH, Henriques F, Liu D, Lee A, Goldstein L, Kelly M, Nicoloro SM, Chen M, Weinstein L, Collins S, Czech MP
(2020) Cell Rep 31: 107598
MeSH Terms: Adipocytes, Adipose Tissue, Brown, Adipose Tissue, White, Adrenergic Agents, Animals, Lipogenesis, Mice, Transgenic, Signal Transduction, Thermogenesis, Thyroid Hormones
Added July 22, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease.
Nlandu-Khodo S, Osaki Y, Scarfe L, Yang H, Phillips-Mignemi M, Tonello J, Saito-Diaz K, Neelisetty S, Ivanova A, Huffstater T, McMahon R, Taketo MM, deCaestecker M, Kasinath B, Harris RC, Lee E, Gewin LS
(2020) JCI Insight 5:
MeSH Terms: Acute Kidney Injury, Animals, Forkhead Box Protein O3, Kidney Tubules, Proximal, Male, Mice, Mice, Transgenic, Renal Insufficiency, Chronic, Signal Transduction, beta Catenin
Added May 8, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms
Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.
Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, Bimczok D, Schneider C, Gobert AP, Wilson KT
(2020) Oncogene 39: 4465-4474
MeSH Terms: Adenocarcinoma, Animals, Cell Transformation, Neoplastic, DNA Damage, Gastritis, Helicobacter Infections, Helicobacter pylori, Mice, Mice, Inbred C57BL, Mice, Knockout, Organoids, Oxidoreductases Acting on CH-NH Group Donors, Proteome, RNA, Messenger, Signal Transduction, Spermidine, Spermine, Stomach Neoplasms, beta Catenin
Added May 1, 2020
0 Communities
1 Members
0 Resources
19 MeSH Terms
Long non-coding RNA enhances chondrogenesis via suppression of the interferon type II signaling pathway.
Huynh NP, Gloss CC, Lorentz J, Tang R, Brunger JM, McAlinden A, Zhang B, Guilak F
(2020) Elife 9:
MeSH Terms: Binding Sites, Cell Differentiation, Cells, Cultured, Chondrocytes, Chondrogenesis, Extracellular Matrix, Gene Editing, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Humans, Immunohistochemistry, Interferon-gamma, Mesenchymal Stem Cells, Protein Binding, RNA, Long Noncoding, Signal Transduction
Added March 16, 2021
0 Communities
1 Members
0 Resources
17 MeSH Terms
A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure.
Ceddia RP, Collins S
(2020) Clin Sci (Lond) 134: 473-512
MeSH Terms: Adipocytes, Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Lipolysis, Nucleotides, Cyclic, Receptors, G-Protein-Coupled, Signal Transduction
Added March 26, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms