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Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR
(2013) J Med Chem 56: 534-46
MeSH Terms: Acetamides, Drug Discovery, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Structure, Protease Inhibitors, SARS Virus, Severe Acute Respiratory Syndrome, Small Molecule Libraries, Structure-Activity Relationship
Added March 7, 2014
1 Communities
1 Members
0 Resources
10 MeSH Terms
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS
(2012) Nat Med 18: 1820-6
MeSH Terms: Age Factors, Animals, Base Sequence, DNA Primers, Drug Design, Exoribonucleases, Female, Immunocompromised Host, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmids, Real-Time Polymerase Chain Reaction, SARS Virus, Sequence Analysis, DNA, Severe Acute Respiratory Syndrome, Statistics, Nonparametric, Viral Vaccines, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR
(2010) PLoS Pathog 6: e1000896
MeSH Terms: Amino Acid Sequence, Animals, Chlorocebus aethiops, Evolution, Molecular, Exoribonucleases, Genetic Engineering, Genetic Variation, Genome, Viral, Models, Genetic, Molecular Sequence Data, Mutation, Phenotype, Polymorphism, Single Nucleotide, SARS Virus, Severe Acute Respiratory Syndrome, Vero Cells, Viral Nonstructural Proteins, Virus Replication
Added August 16, 2012
1 Communities
1 Members
0 Resources
18 MeSH Terms
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.
Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR
(2008) Proc Natl Acad Sci U S A 105: 19944-9
MeSH Terms: Amino Acid Sequence, Animals, Cells, Cultured, Chiroptera, Chlorocebus aethiops, Female, Humans, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Recombinant Proteins, Recombination, Genetic, Respiratory Mucosa, SARS Virus, Severe Acute Respiratory Syndrome, Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins, Virus Replication, Zoonoses
Added February 19, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome.
Tansey CM, Louie M, Loeb M, Gold WL, Muller MP, de Jager J, Cameron JI, Tomlinson G, Mazzulli T, Walmsley SL, Rachlis AR, Mederski BD, Silverman M, Shainhouse Z, Ephtimios IE, Avendano M, Downey J, Styra R, Yamamura D, Gerson M, Stanbrook MB, Marras TK, Phillips EJ, Zamel N, Richardson SE, Slutsky AS, Herridge MS
(2007) Arch Intern Med 167: 1312-20
MeSH Terms: Adult, Delivery of Health Care, Disability Evaluation, Disease Outbreaks, Female, Follow-Up Studies, Humans, Male, Middle Aged, Ontario, Outcome Assessment, Health Care, Prognosis, Prospective Studies, Quality of Life, Respiratory Function Tests, Severe Acute Respiratory Syndrome, Surveys and Questionnaires, Walking
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
SARS coronavirus replicase proteins in pathogenesis.
Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR
(2008) Virus Res 133: 88-100
MeSH Terms: Animals, Chlorocebus aethiops, Humans, Open Reading Frames, RNA-Dependent RNA Polymerase, SARS Virus, Severe Acute Respiratory Syndrome, Vero Cells, Viral Nonstructural Proteins, Virulence
Added February 19, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update.
Denison MR
(2004) Pediatr Infect Dis J 23: S207-14
MeSH Terms: Adolescent, Adult, Age Factors, Animals, Antibodies, Viral, Child, Disease Models, Animal, Disease Outbreaks, Humans, SARS Virus, Severe Acute Respiratory Syndrome, Severity of Illness Index, Viral Vaccines, Zoonoses
Added February 19, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience.
Tang P, Louie M, Richardson SE, Smieja M, Simor AE, Jamieson F, Fearon M, Poutanen SM, Mazzulli T, Tellier R, Mahony J, Loeb M, Petrich A, Chernesky M, McGeer A, Low DE, Phillips E, Jones S, Bastien N, Li Y, Dick D, Grolla A, Fernando L, Booth TF, Henry B, Rachlis AR, Matukas LM, Rose DB, Lovinsky R, Walmsley S, Gold WL, Krajden S, Ontario Laboratory Working Group for the Rapid Diagnosis of Emerging Infections
(2004) CMAJ 170: 47-54
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Clinical Laboratory Techniques, Communicable Diseases, Emerging, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Ontario, Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Severe Acute Respiratory Syndrome
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus.
Yount B, Curtis KM, Fritz EA, Hensley LE, Jahrling PB, Prentice E, Denison MR, Geisbert TW, Baric RS
(2003) Proc Natl Acad Sci U S A 100: 12995-3000
MeSH Terms: Animals, Base Sequence, Chlorocebus aethiops, Cloning, Molecular, Consensus Sequence, DNA, Complementary, Genetic Markers, Genetic Techniques, Humans, Open Reading Frames, SARS Virus, Severe Acute Respiratory Syndrome, Transcription, Genetic, Vero Cells
Added February 19, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada.
Knowles SR, Phillips EJ, Dresser L, Matukas L
(2003) Clin Infect Dis 37: 1139-42
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Anemia, Hemolytic, Antiviral Agents, Canada, Disease Outbreaks, Female, Humans, Hypocalcemia, Male, Middle Aged, Ribavirin, Severe Acute Respiratory Syndrome
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms