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Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.
Xiao S, Brooks CR, Sobel RA, Kuchroo VK
(2015) J Immunol 194: 1602-8
MeSH Terms: Animals, B-Lymphocytes, Regulatory, Encephalomyelitis, Autoimmune, Experimental, Flow Cytometry, Hepatitis A Virus Cellular Receptor 1, Inflammation, Interleukin-10, Lymphocyte Activation, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Real-Time Polymerase Chain Reaction, Self Tolerance
Show Abstract · Added September 12, 2016
T cell Ig and mucin domain (Tim)-1 identifies IL-10-producing regulatory B cells (Bregs). Mice on the C57BL/6 background harboring a loss-of-function Tim-1 mutant showed progressive loss of IL-10 production in B cells and with age developed severe multiorgan tissue inflammation. We demonstrate that Tim-1 expression and signaling in Bregs are required for optimal production of IL-10. B cells with Tim-1 defects have impaired IL-10 production but increased proinflammatory cytokine production, including IL-1 and IL-6. Tim-1-deficient B cells promote Th1 and Th17 responses but inhibit the generation of regulatory T cells (Foxp3(+) and IL-10-producing type 1 regulatory T cells) and enhance the severity of experimental autoimmune encephalomyelitis. Mechanistically, Tim-1 on Bregs is required for apoptotic cell (AC) binding to Bregs and for AC-induced IL-10 production in Bregs. Treatment with ACs reduces the severity of experimental autoimmune encephalomyelitis in hosts with wild-type but not Tim-1-deficient Bregs. Collectively, these findings suggest that in addition to serving as a marker for identifying IL-10-producing Bregs, Tim-1 is also critical for maintaining self-tolerance by regulating IL-10 production in Bregs.
Copyright © 2015 by The American Association of Immunologists, Inc.
1 Communities
1 Members
0 Resources
14 MeSH Terms
B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.
Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW
(2013) J Immunol 190: 5992-6003
MeSH Terms: Amino Acid Sequence, Animals, Autoantigens, Autoimmunity, B-Lymphocytes, Bone Marrow Cells, Cell Separation, Diabetes Mellitus, Type 1, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunoglobulin Variable Region, Insulin, Islets of Langerhans, Lymphocyte Activation, Mice, Mice, Inbred NOD, Molecular Sequence Data, Self Tolerance
Show Abstract · Added January 23, 2014
Effective central tolerance is required to control the large extent of autoreactivity normally present in the developing B cell repertoire. Insulin-reactive B cells are required for type 1 diabetes in the NOD mouse, because engineered mice lacking this population are protected from disease. The Cg-Tg(Igh-6/Igh-V125)2Jwt/JwtJ (VH125Tg) model is used to define this population, which is found with increased frequency in the periphery of NOD mice versus nonautoimmune C57BL/6 VH125Tg mice; however, the ontogeny of this disparity is unknown. To better understand the origins of these pernicious B cells, anti-insulin B cells were tracked during development in the polyclonal repertoire of VH125Tg mice. An increased proportion of insulin-binding B cells is apparent in NOD mice at the earliest point of Ag commitment in the bone marrow. Two predominant L chains were identified in B cells that bind heterologous insulin. Interestingly, Vκ4-57-1 polymorphisms that confer a CDR3 Pro-Pro motif enhance self-reactivity in VH125Tg/NOD mice. Despite binding circulating autoantigen in vivo, anti-insulin B cells transition from the parenchyma to the sinusoids in the bone marrow of NOD mice and enter the periphery unimpeded. Anti-insulin B cells expand at the site of autoimmune attack in the pancreas and correlate with increased numbers of IFN-γ-producing cells in the repertoire. These data identify the failure to cull autoreactive B cells in the bone marrow as the primary source of anti-insulin B cells in NOD mice and suggest that dysregulation of central tolerance permits their escape into the periphery to promote disease.
3 Communities
3 Members
0 Resources
18 MeSH Terms
Natural killer T cells and autoimmune disease.
Wu L, Van Kaer L
(2009) Curr Mol Med 9: 4-14
MeSH Terms: Animals, Arthritis, Rheumatoid, Autoimmune Diseases, Autoimmunity, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Immunity, Innate, Immunotherapy, Liver Cirrhosis, Biliary, Lupus Erythematosus, Systemic, Mice, Multiple Sclerosis, Myasthenia Gravis, Natural Killer T-Cells, Self Tolerance
Show Abstract · Added December 10, 2013
Natural killer T (NKT) cells are an unusual subset of innate immune cells that express a surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the adaptive immune system. NKT cells express a highly restricted repertoire of T cell receptors that recognize glycolipid antigens bound with the antigen-presenting molecule CD1d. A hallmark of NKT cells is their capacity to produce copious amounts of immunomodulatory cytokines upon antigenic stimulation, which endows these cells with potent immunoregulatory properties. Consequently, NKT cells have been implicated in regulating a wide variety of immune responses, including immune responses against autoantigens. In patients and mice with a variety of autoimmune diseases, numbers and functions of NKT cells are disturbed, but the relevance of these findings to the etiology of autoimmunity remains to be fully established. Nevertheless, in some mouse models of autoimmunity, NKT cell-deficiency exacerbates disease, suggesting that NKT cells play a role in suppressing autoimmunity. Conversely, specific activation of NKT cells with glycolipid antigens generally protects mice against the development of autoimmunity. Most of these studies have employed the potent sponge-derived NKT cell antigen alpha-galactosylceramide (alpha-GalCer). However, alpha-GalCer treatment in mice was associated with detrimental side effects and treatment efficacy was influenced by a variety of parameters, resulting sometimes in disease exacerbation rather than protection. Recent efforts have focused on developing NKT cell agonists with superior treatment efficacy than alpha-GalCer. Collectively, these studies have identified NKT cells as attractive targets for treatment of human autoimmune diseases.
0 Communities
2 Members
0 Resources
16 MeSH Terms