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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 35

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Cytokine-mediated changes in K channel activity promotes an adaptive Ca response that sustains β-cell insulin secretion during inflammation.
Dickerson MT, Bogart AM, Altman MK, Milian SC, Jordan KL, Dadi PK, Jacobson DA
(2018) Sci Rep 8: 1158
MeSH Terms: Adult, Animals, Calcium, Female, Gene Expression Regulation, Glucose, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Interferon-gamma, Interleukin-1beta, Ion Transport, Islets of Langerhans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Potassium, Potassium Channels, Tandem Pore Domain, Primary Cell Culture, RNA, Messenger, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Tissue Culture Techniques, Tumor Necrosis Factor-alpha
Added February 7, 2018
0 Communities
1 Members
0 Resources
25 MeSH Terms
Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.
Kirabo A, Ryzhov S, Gupte M, Sengsayadeth S, Gumina RJ, Sawyer DB, Galindo CL
(2017) J Mol Cell Cardiol 105: 59-69
MeSH Terms: Calcium, Calcium Signaling, Cell Line, Cell Proliferation, Cell Survival, Heart Ventricles, Humans, Intracellular Space, Myofibroblasts, Neuregulin-1, Paracrine Communication, Sarcoplasmic Reticulum, Signal Transduction
Added December 27, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.
Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ
(2017) Circ Heart Fail 10:
MeSH Terms: Adult, Animals, Calcium Channels, L-Type, Calcium Signaling, Calcium-Binding Proteins, Cardiomyopathies, Case-Control Studies, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Male, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Myocardial Infarction, Myocardial Reperfusion Injury, Myocardium, Oxidative Stress, Phenotype, Potassium Channels, Inwardly Rectifying, Reactive Nitrogen Species, Reactive Oxygen Species, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Tyrosine, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Pressure
Added April 6, 2017
0 Communities
2 Members
0 Resources
28 MeSH Terms
Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.
Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC
(2015) J Mol Cell Cardiol 85: 79-88
MeSH Terms: Animals, Calcium, Calcium Signaling, Cell Differentiation, Cells, Cultured, Humans, Induced Pluripotent Stem Cells, Mice, Myocardial Contraction, Myocytes, Cardiac, Rabbits, Sarcoplasmic Reticulum
Added June 2, 2015
1 Communities
2 Members
0 Resources
12 MeSH Terms
Mitochondrial calcium handling within the interstitial cells of Cajal.
Means SA, Cheng LK
(2014) Am J Physiol Gastrointest Liver Physiol 307: G107-21
MeSH Terms: Animals, Biological Clocks, Calcium, Calcium Signaling, Computer Simulation, Endoplasmic Reticulum, Humans, Inositol 1,4,5-Trisphosphate Receptors, Interstitial Cells of Cajal, Membrane Potentials, Mitochondria, Models, Biological, Periodicity, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Time Factors
Added April 26, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.
Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV
(2015) Eur Heart J 36: 686-97
MeSH Terms: Action Potentials, Animals, Atrial Fibrillation, Atrial Function, Bradycardia, Calcium, Calsequestrin, Cardiomegaly, Fibrosis, Gene Deletion, Gene Knockout Techniques, Mice, Transgenic, Sarcoplasmic Reticulum, Sinoatrial Node
Added February 12, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N
(2013) Antioxid Redox Signal 19: 1185-97
MeSH Terms: Adenosine Triphosphate, Animals, Antioxidants, Calcium, Calcium Signaling, Calcium-Binding Proteins, Cardiotonic Agents, Cyclic AMP-Dependent Protein Kinases, Disulfides, Heart Ventricles, In Vitro Techniques, Mice, Mice, Knockout, Microsomes, Myocytes, Cardiac, Nitrogen Oxides, Oxidation-Reduction, Phosphorylation, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Stability, Sarcoplasmic Reticulum, Sarcoplasmic Reticulum Calcium-Transporting ATPases
Added May 27, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.
Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA
(2013) Am J Physiol Heart Circ Physiol 305: H1068-79
MeSH Terms: Acetanilides, Animals, Calcium Channels, L-Type, Calcium Signaling, Disease Models, Animal, Disease Progression, Dose-Response Relationship, Drug, Heart Failure, Hypertension, Hypertrophy, Left Ventricular, Male, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Piperazines, Ranolazine, Rats, Rats, Inbred SHR, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sodium, Sodium Channel Blockers, Sodium Channels, Sodium-Calcium Exchanger, Time Factors, Ultrasonography
Added February 28, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Triadin regulates cardiac muscle couplon structure and microdomain Ca(2+) signalling: a path towards ventricular arrhythmias.
Chopra N, Knollmann BC
(2013) Cardiovasc Res 98: 187-91
MeSH Terms: Animals, Calcium Channels, L-Type, Calcium Signaling, Calsequestrin, Carrier Proteins, Excitation Contraction Coupling, Humans, Membrane Microdomains, Muscle Proteins, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Tachycardia, Ventricular
Added February 12, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms