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Results: 1 to 9 of 9

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Atropisomeric dihydroanthracenones as inhibitors of multiresistant Staphylococcus aureus.
Bara R, Zerfass I, Aly AH, Goldbach-Gecke H, Raghavan V, Sass P, Mándi A, Wray V, Polavarapu PL, Pretsch A, Lin W, Kurtán T, Debbab A, Brötz-Oesterhelt H, Proksch P
(2013) J Med Chem 56: 3257-72
MeSH Terms: Aloe, Animals, Anthracenes, Anti-Bacterial Agents, BALB 3T3 Cells, Cell Line, Tumor, DNA, Bacterial, Drug Resistance, Multiple, Bacterial, Endophytes, Eurotiales, Humans, Mice, Microbial Sensitivity Tests, Nuclear Magnetic Resonance, Biomolecular, SOS Response, Genetics, Staphylococcus aureus, Stereoisomerism
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.
Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T
(2001) Mutat Res 497: 223-33
MeSH Terms: Acetyltransferases, Aryl Hydrocarbon Hydroxylases, Biotransformation, Carcinogens, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, In Vitro Techniques, Microsomes, Liver, Mutagens, NADPH-Ferrihemoprotein Reductase, Pyrenes, Recombinant Proteins, SOS Response, Genetics, Salmonella typhimurium
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay.
Aryal P, Terashita T, Guengerich FP, Shimada T, Oda Y
(2000) Environ Mol Mutagen 36: 121-6
MeSH Terms: Acetyltransferases, Bacterial Proteins, Carbolines, Carcinogens, Cytochrome P-450 CYP1A2, DNA-Directed DNA Polymerase, Escherichia coli Proteins, Genetic Engineering, Humans, Mutagenicity Tests, Mutagens, NADPH-Ferrihemoprotein Reductase, Quinolines, SOS Response, Genetics, Salmonella typhimurium
Added May 26, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase.
Johnson WW, Yamazaki H, Shimada T, Ueng YF, Guengerich FP
(1997) Chem Res Toxicol 10: 672-6
MeSH Terms: Aflatoxin B1, Animals, Epoxide Hydrolases, Humans, Hydrolysis, Kinetics, Liver, Mutagenicity Tests, Rabbits, Rats, SOS Response, Genetics
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
New applications of bacterial systems to problems in toxicology.
Guengerich FP, Gillam EM, Shimada T
(1996) Crit Rev Toxicol 26: 551-83
MeSH Terms: Amino Acid Sequence, Animals, Bacteria, Biotransformation, Cytochrome P-450 Enzyme System, DNA, Complementary, Gene Expression Regulation, Enzymologic, Humans, Immunoblotting, Molecular Sequence Data, Mutagenicity Tests, Recombinant Proteins, SOS Response, Genetics, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives.
Humphreys WG, Kim DH, Cmarik JL, Shimada T, Guengerich FP
(1990) Biochemistry 29: 10342-50
MeSH Terms: Alkylating Agents, Base Composition, Cysteine, DNA, DNA Repair, Gene Expression, Glutathione, Hydrocarbons, Halogenated, Mutagens, Plasmids, SOS Response, Genetics, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Activation of mutagens by human cytochrome P-450 enzymes.
Guengerich FP, Shimada T, Iwasaki M, Martin MV
(1990) Prog Clin Biol Res 340B: 87-96
MeSH Terms: Alkylation, Bacterial Proteins, Biotransformation, Carcinogens, Cytochrome P-450 Enzyme System, DNA Damage, Enzyme Induction, Humans, Isoenzymes, Mutagens, Oxidation-Reduction, Recombinant Fusion Proteins, SOS Response, Genetics, Salmonella typhimurium, beta-Galactosidase
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
Shimada T, Guengerich FP
(1991) Cancer Res 51: 5284-91
MeSH Terms: Aflatoxin B1, Animals, Aroclors, Benzoflavones, Carbolines, Chlorodiphenyl (54% Chlorine), Cytochrome P-450 Enzyme System, DNA, Dose-Response Relationship, Drug, Humans, Imidazoles, In Vitro Techniques, Male, Microsomes, Liver, Mutagens, Plants, Toxic, Quinidine, Rats, Rats, Inbred Strains, SOS Response, Genetics, Safrole, Smoke, Tobacco, beta-Galactosidase
Added March 5, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response.
Benamira M, Marnett LJ
(1992) Mutat Res 293: 1-10
MeSH Terms: Acrolein, Aldehydes, Lipid Peroxidation, Malondialdehyde, Mutagens, Operon, SOS Response, Genetics, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms