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Results: 1 to 10 of 16

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Coronaviruses induce entry-independent, continuous macropinocytosis.
Freeman MC, Peek CT, Becker MM, Smith EC, Denison MR
(2014) mBio 5: e01340-14
MeSH Terms: Animals, Cell Line, Tumor, Coronavirus, Mice, Pinocytosis, Pseudopodia, SARS Virus, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease.
Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, Stauffer SR
(2013) J Med Chem 56: 534-46
MeSH Terms: Acetamides, Drug Discovery, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Structure, Protease Inhibitors, SARS Virus, Severe Acute Respiratory Syndrome, Small Molecule Libraries, Structure-Activity Relationship
Added March 7, 2014
1 Communities
1 Members
0 Resources
10 MeSH Terms
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS
(2012) Nat Med 18: 1820-6
MeSH Terms: Age Factors, Animals, Base Sequence, DNA Primers, Drug Design, Exoribonucleases, Female, Immunocompromised Host, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmids, Real-Time Polymerase Chain Reaction, SARS Virus, Sequence Analysis, DNA, Severe Acute Respiratory Syndrome, Statistics, Nonparametric, Viral Vaccines, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M
(2011) PLoS Pathog 7: e1001258
MeSH Terms: Animals, Antigens, Differentiation, Cell Line, Tumor, Chlorocebus aethiops, Endothelium, Vascular, Female, Filoviridae, Host-Pathogen Interactions, Humans, Influenza A virus, Mice, SARS Virus, Vero Cells, Virus Diseases, Virus Internalization, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing.
Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR
(2010) PLoS Pathog 6: e1000896
MeSH Terms: Amino Acid Sequence, Animals, Chlorocebus aethiops, Evolution, Molecular, Exoribonucleases, Genetic Engineering, Genetic Variation, Genome, Viral, Models, Genetic, Molecular Sequence Data, Mutation, Phenotype, Polymorphism, Single Nucleotide, SARS Virus, Severe Acute Respiratory Syndrome, Vero Cells, Viral Nonstructural Proteins, Virus Replication
Added August 16, 2012
1 Communities
1 Members
0 Resources
18 MeSH Terms
Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.
Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR
(2008) Proc Natl Acad Sci U S A 105: 19944-9
MeSH Terms: Amino Acid Sequence, Animals, Cells, Cultured, Chiroptera, Chlorocebus aethiops, Female, Humans, Membrane Glycoproteins, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Recombinant Proteins, Recombination, Genetic, Respiratory Mucosa, SARS Virus, Severe Acute Respiratory Syndrome, Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins, Virus Replication, Zoonoses
Added February 19, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
SARS coronavirus replicase proteins in pathogenesis.
Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR
(2008) Virus Res 133: 88-100
MeSH Terms: Animals, Chlorocebus aethiops, Humans, Open Reading Frames, RNA-Dependent RNA Polymerase, SARS Virus, Severe Acute Respiratory Syndrome, Vero Cells, Viral Nonstructural Proteins, Virulence
Added February 19, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication.
Graham RL, Sims AC, Baric RS, Denison MR
(2006) Adv Exp Med Biol 581: 67-72
MeSH Terms: Animals, Cell Line, Cysteine Endopeptidases, Gene Deletion, Genome, Viral, Microscopy, Confocal, Microscopy, Fluorescence, Murine hepatitis virus, Open Reading Frames, Polyproteins, SARS Virus, Species Specificity, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H
(2006) J Biol Chem 281: 3198-203
MeSH Terms: Angiotensin-Converting Enzyme 2, Animals, Carboxypeptidases, Cathepsin L, Cathepsins, Cell Line, Chlorocebus aethiops, Coronavirus, Cysteine Endopeptidases, Endosomes, Green Fluorescent Proteins, Humans, Lysosomes, Membrane Glycoproteins, Peptidyl-Dipeptidase A, Retroviridae, SARS Virus, Species Specificity, Vero Cells, Viral Envelope Proteins
Added December 10, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice.
Yount B, Roberts RS, Sims AC, Deming D, Frieman MB, Sparks J, Denison MR, Davis N, Baric RS
(2005) J Virol 79: 14909-22
MeSH Terms: Animals, Coronavirus Infections, Mice, Open Reading Frames, SARS Virus, Viral Proteins, Viral Structural Proteins, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms