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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 14

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SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer.
Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z
(2017) Oncogene 36: 1364-1373
MeSH Terms: Animals, Cell Line, Tumor, Disease Models, Animal, Enhancer of Zeste Homolog 2 Protein, Gene Knockout Techniques, Histones, Humans, Lysine, Male, Mice, PTEN Phosphohydrolase, Prostate, Prostatic Neoplasms, Protein Stability, S-Phase Kinase-Associated Proteins, TNF Receptor-Associated Factor 6, Tumor Suppressor Protein p53, Ubiquitination
Added April 18, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms
CacyBP/SIP--Structure and variety of functions.
Topolska-Woś AM, Chazin WJ, Filipek A
(2016) Biochim Biophys Acta 1860: 79-85
MeSH Terms: Calcium-Binding Proteins, Cell Differentiation, Extracellular Signal-Regulated MAP Kinases, Neoplasms, Nuclear Proteins, Phosphorylation, Protein Processing, Post-Translational, S-Phase Kinase-Associated Proteins, Tropomyosin, Ubiquitin-Protein Ligases
Added March 11, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination.
Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z
(2015) Oncotarget 6: 771-88
MeSH Terms: Animals, Carcinogenesis, Cell Proliferation, DNA-Binding Proteins, Disease Progression, Female, Humans, Jumonji Domain-Containing Histone Demethylases, Male, Mice, Mice, Knockout, Mice, Transgenic, Nuclear Proteins, Prostatic Neoplasms, Repressor Proteins, S-Phase Kinase-Associated Proteins, Ubiquitination
Added January 20, 2015
1 Communities
1 Members
0 Resources
17 MeSH Terms
Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer.
Li B, Lu W, Yang Q, Yu X, Matusik RJ, Chen Z
(2014) Prostate 74: 421-32
MeSH Terms: Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Imidazoles, Male, Phosphorylation, Prostatic Neoplasms, Proto-Oncogene Proteins c-akt, Quinolines, Receptors, Androgen, S-Phase Kinase-Associated Proteins, Signal Transduction, TOR Serine-Threonine Kinases, Ubiquitin, Ubiquitination
Added March 20, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.
Zhang Q, Spears E, Boone DN, Li Z, Gregory MA, Hann SR
(2013) Proc Natl Acad Sci U S A 110: 978-83
MeSH Terms: Amino Acid Substitution, Animals, Apoptosis, Binding, Competitive, Cell Transformation, Neoplastic, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p16, Early Growth Response Protein 1, Gene Knockout Techniques, Genes, myc, HeLa Cells, Humans, Mice, Mutagenesis, Site-Directed, Protein Structure, Tertiary, Proto-Oncogene Proteins c-myc, S-Phase Kinase-Associated Proteins, Transcription, Genetic, Ubiquitination
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.
Dimitrova YN, Li J, Lee YT, Rios-Esteves J, Friedman DB, Choi HJ, Weis WI, Wang CY, Chazin WJ
(2010) J Biol Chem 285: 13507-16
MeSH Terms: Adaptor Proteins, Signal Transducing, Adenomatous Polyposis Coli Protein, Animals, Calcium-Binding Proteins, Cell Line, Cell-Free System, Humans, Mice, Nuclear Proteins, Phosphoproteins, Proteasome Endopeptidase Complex, S-Phase Kinase-Associated Proteins, Signal Transduction, Transducin, Tumor Suppressor Protein p53, Ubiquitin-Protein Ligases, Ubiquitination, Wnt Proteins, beta Catenin
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron.
Plesca D, Mazumder S, Gama V, Matsuyama S, Almasan A
(2008) J Biol Chem 283: 30796-803
MeSH Terms: Antigens, Nuclear, Apoptosis, Boronic Acids, Bortezomib, Caspases, Cell Cycle Proteins, Cell Line, Tumor, Cullin Proteins, Cyclin E, DNA-Binding Proteins, F-Box Proteins, F-Box-WD Repeat-Containing Protein 7, Half-Life, Hematologic Neoplasms, Humans, Isoenzymes, Ku Autoantigen, Neoplasm Proteins, Phosphorylation, Protease Inhibitors, Proteasome Endopeptidase Complex, Proto-Oncogene Proteins c-mdm2, Pyrazines, S-Phase Kinase-Associated Proteins, Ubiquitin-Protein Ligases, Ubiquitination, bcl-2-Associated X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
27 MeSH Terms
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
(2006) Mol Cell Biol 26: 7977-90
MeSH Terms: Animals, Ataxia Telangiectasia Mutated Proteins, Cell Cycle, Cell Cycle Proteins, Cell Line, Chromosomes, Human, Cullin Proteins, DNA Damage, DNA Repair, DNA Replication, DNA-Binding Proteins, Genes, cdc, Genome, Human, Genomic Instability, Humans, Protein Subunits, Protein-Serine-Threonine Kinases, RNA, Small Interfering, S-Phase Kinase-Associated Proteins, Tumor Suppressor Proteins, Xeroderma Pigmentosum, Xeroderma Pigmentosum Group A Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies.
Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, Kuznicki J, Chazin WJ
(2005) Biochemistry 44: 9462-71
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Calcium-Binding Proteins, Crystallography, X-Ray, Dimerization, Mice, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Nuclear Proteins, Peptide Fragments, Protein Interaction Mapping, Protein Processing, Post-Translational, Protein Structure, Secondary, Protein Structure, Tertiary, S-Phase Kinase-Associated Proteins, SKP Cullin F-Box Protein Ligases, Ubiquitin-Protein Ligases
Added December 10, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.
Li JQ, Wu F, Masaki T, Kubo A, Fujita J, Dixon DA, Beauchamp RD, Ishida T, Kuriyama S, Imaida K
(2004) Int J Oncol 25: 87-95
MeSH Terms: Aged, Biomarkers, Tumor, Colonic Neoplasms, Colorectal Neoplasms, Cyclins, Female, Humans, Immunohistochemistry, Intestinal Mucosa, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Prognosis, Rectal Neoplasms, S-Phase Kinase-Associated Proteins
Added May 3, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms