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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 28

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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Kryshtal DO, Blackwell DJ, Egly CL, Smith AN, Batiste SM, Johnston JN, Laver DR, Knollmann BC
(2021) Circ Res 128: 321-331
MeSH Terms: Action Potentials, Animals, Anti-Arrhythmia Agents, Calcium Channel Blockers, Calcium Signaling, Calsequestrin, Disease Models, Animal, Female, Flecainide, HEK293 Cells, Heart Rate, Humans, Male, Mice, Knockout, Myocytes, Cardiac, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum, Sheep, Domestic, Tachycardia, Ventricular, Voltage-Gated Sodium Channel Blockers
Added December 21, 2020
1 Communities
0 Members
0 Resources
21 MeSH Terms
Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.
Chazin WJ, Johnson CN
(2020) Int J Mol Sci 21:
MeSH Terms: Arrhythmias, Cardiac, Calcium Signaling, Calmodulin, Humans, Ion Channels, Long QT Syndrome, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 11, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia.
Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC
(2020) Europace 22: 643-648
MeSH Terms: Animals, Atropine, Humans, Mice, Prospective Studies, Ryanodine Receptor Calcium Release Channel, Tachycardia, Sinus, Tachycardia, Ventricular
Added March 24, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.
Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR
(2017) J Am Coll Cardiol 70: 115-117
MeSH Terms: Calmodulin, Heart Ventricles, Humans, In Vitro Techniques, Mutation, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 24, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer's Disease Genetics Consortium
(2016) Neurobiol Aging 38: 141-150
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Alzheimer Disease, Cadherins, Calcium Channels, L-Type, Datasets as Topic, Disease Progression, Epistasis, Genetic, Female, Genetic Association Studies, Humans, Male, Models, Genetic, Phosphatidylethanolamine Binding Protein, Polymorphism, Single Nucleotide, Receptors, Adrenergic, alpha-1, Receptors, N-Methyl-D-Aspartate, Risk, Ryanodine Receptor Calcium Release Channel, Saposins, Sirtuin 1
Added April 10, 2018
0 Communities
1 Members
0 Resources
20 MeSH Terms
Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release.
S√łndergaard MT, Tian X, Liu Y, Wang R, Chazin WJ, Chen SR, Overgaard MT
(2015) J Biol Chem 290: 26151-62
MeSH Terms: Arrhythmias, Cardiac, Calcium, Calmodulin, HEK293 Cells, Humans, Mutation, Myocardium, Ryanodine Receptor Calcium Release Channel
Added March 11, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Savio-Galimberti E, Knollmann BC
(2015) PLoS One 10: e0131179
MeSH Terms: Animals, Arrhythmias, Cardiac, Caffeine, Calcium, Calcium Signaling, Calsequestrin, Cell Membrane Permeability, Flecainide, Heart Ventricles, Humans, Inhibitory Concentration 50, Male, Mice, Inbred C57BL, Myocytes, Cardiac, Propafenone, Rabbits, Ryanodine Receptor Calcium Release Channel, Tetracaine
Added February 22, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Multiple modes of ryanodine receptor 2 inhibition by flecainide.
Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR
(2014) Mol Pharmacol 86: 696-706
MeSH Terms: Animals, Calcium, Calcium Channel Blockers, Flecainide, Hydrogen-Ion Concentration, Magnesium, Ryanodine Receptor Calcium Release Channel, Sheep
Added February 12, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.
Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL, Cornea RL, Bers DM, Knollmann BC
(2014) Circ Res 114: 1114-24
MeSH Terms: Animals, Calcium, Calcium Signaling, Calmodulin, Heart Ventricles, Mice, Mice, Inbred C57BL, Mutation, Missense, Myocytes, Cardiac, Protein Binding, Ryanodine Receptor Calcium Release Channel
Added March 12, 2014
0 Communities
2 Members
0 Resources
11 MeSH Terms
Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.
Liu B, Ho HT, Velez-Cortes F, Lou Q, Valdivia CR, Knollmann BC, Valdivia HH, Gyorke S
(2014) J Physiol 592: 1957-73
MeSH Terms: Animals, Calcium, Cardiomyopathies, Female, Male, Mice, Mice, Knockout, Mice, Transgenic, Phosphorylation, Ryanodine Receptor Calcium Release Channel, Serine
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms