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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 47

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ERα-Mediated Nuclear Sequestration of RSK2 Is Required for ER Breast Cancer Tumorigenesis.
Ludwik KA, McDonald OG, Brenin DR, Lannigan DA
(2018) Cancer Res 78: 2014-2025
MeSH Terms: Animals, Breast Neoplasms, Carcinogenesis, Cell Nucleus, Estrogen Receptor alpha, Female, Humans, MCF-7 Cells, Mice, Mice, Inbred C57BL, Neoplasm Invasiveness, Ribosomal Protein S6 Kinases, 90-kDa
Added July 20, 2018
0 Communities
2 Members
0 Resources
12 MeSH Terms
Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer.
Ludwik KA, Campbell JP, Li M, Li Y, Sandusky ZM, Pasic L, Sowder ME, Brenin DR, Pietenpol JA, O'Doherty GA, Lannigan DA
(2016) Mol Cancer Ther 15: 2598-2608
MeSH Terms: Animals, Antineoplastic Agents, Benzopyrans, Cell Line, Tumor, Cell Movement, Cell Proliferation, Cell Survival, Disease Models, Animal, Dose-Response Relationship, Drug, Enzyme Activation, Female, Gene Silencing, Humans, Mice, Monosaccharides, Neoplasm Metastasis, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 90-kDa, Triple Negative Breast Neoplasms, Tumor Burden, Xenograft Model Antitumor Assays
Added September 14, 2016
1 Communities
3 Members
0 Resources
22 MeSH Terms
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines.
Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC
(2016) Pathol Oncol Res 22: 797-805
MeSH Terms: Adaptor Proteins, Signal Transducing, Cell Cycle Proteins, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Gene Expression, Humans, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphoproteins, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Stomach Neoplasms, TOR Serine-Threonine Kinases
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S
(2016) J Clin Invest 126: 1704-16
MeSH Terms: 3T3-L1 Cells, Adaptor Proteins, Signal Transducing, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Cyclic AMP-Dependent Protein Kinases, HEK293 Cells, Humans, Insulin, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Knockout, Multiprotein Complexes, Receptors, Adrenergic, beta, Regulatory-Associated Protein of mTOR, Ribosomal Protein S6 Kinases, 70-kDa, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, TOR Serine-Threonine Kinases, Uncoupling Protein 1
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
Coffey RT, Shi Y, Long MJ, Marr MT, Hedstrom L
(2016) J Biol Chem 291: 5221-33
MeSH Terms: Adaptor Proteins, Signal Transducing, Arginine, Carbamates, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Enzyme Inhibitors, HEK293 Cells, Humans, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Phosphoproteins, Phosphorylation, Protein Binding, Protein Biosynthesis, Protein Processing, Post-Translational, Ribosomal Protein S6 Kinases, Signal Transduction, TOR Serine-Threonine Kinases, Ubiquitins
Added May 9, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Phosphatidylinositol 3-kinase signaling determines kidney size.
Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC
(2015) J Clin Invest 125: 2429-44
MeSH Terms: Animals, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Immunosuppressive Agents, Kidney, Kidney Diseases, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred DBA, Mice, Knockout, Multiprotein Complexes, Organ Size, Phosphatidylinositol 3-Kinases, Phosphorylation, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases
Added August 5, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC.
Amato KR, Wang S, Hastings AK, Youngblood VM, Santapuram PR, Chen H, Cates JM, Colvin DC, Ye F, Brantley-Sieders DM, Cook RS, Tan L, Gray NS, Chen J
(2014) J Clin Invest 124: 2037-49
MeSH Terms: Animals, Apoptosis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Heterografts, Humans, Lung Neoplasms, Mice, Mice, Knockout, Neoplasm Proteins, Neoplasm Transplantation, Protein Kinase Inhibitors, Receptor, EphA2, Ribosomal Protein S6 Kinases, 70-kDa, Ribosomal Protein S6 Kinases, 90-kDa
Added December 8, 2014
2 Communities
2 Members
0 Resources
16 MeSH Terms
Portal glucose delivery stimulates muscle but not liver protein metabolism.
Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC
(2012) Am J Physiol Endocrinol Metab 303: E1202-11
MeSH Terms: Amino Acid Transport System ASC, Amino Acids, Animals, Dogs, Enteral Nutrition, Glucose, Infusions, Intravenous, Large Neutral Amino Acid-Transporter 1, Liver, Male, Muscle, Skeletal, Phosphorylation, Portal Vein, Postprandial Period, Protein Biosynthesis, Ribosomal Protein S6 Kinases, 70-kDa
Added December 5, 2013
1 Communities
3 Members
1 Resources
16 MeSH Terms
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML
(2012) Gastroenterology 143: 787-798.e13
MeSH Terms: AMP-Activated Protein Kinases, Animals, Apoptosis, Azacitidine, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Carcinoma, Hepatocellular, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cyclic AMP-Dependent Protein Kinases, DNA Methylation, Enzyme Activation, Enzyme Inhibitors, Glycine N-Methyltransferase, Guanine Nucleotide Exchange Factors, Humans, Liver Neoplasms, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Nude, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase Kinases, Phosphorylation, Protein-Serine-Threonine Kinases, RNA Interference, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Time Factors, Transfection, Tumor Burden, ras Guanine Nucleotide Exchange Factors, ras Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
33 MeSH Terms
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.
Oh YT, Yue P, Zhou W, Balko JM, Black EP, Owonikoko TK, Khuri FR, Sun SY
(2012) J Biol Chem 287: 257-267
MeSH Terms: Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Neoplastic, Humans, JNK Mitogen-Activated Protein Kinases, Mutation, Promoter Regions, Genetic, Proto-Oncogene Proteins B-raf, Receptors, TNF-Related Apoptosis-Inducing Ligand, Ribosomal Protein S6 Kinases, Signal Transduction, Transcription Factor CHOP, Transcription, Genetic, ets-Domain Protein Elk-1, ras Proteins
Added March 10, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms