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Results: 1 to 6 of 6

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Distinct roles for p107 and p130 in Rb-independent cellular senescence.
Lehmann BD, Brooks AM, Paine MS, Chappell WH, McCubrey JA, Terrian DM
(2008) Cell Cycle 7: 1262-8
MeSH Terms: Carcinoma, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cellular Senescence, Crk-Associated Substrate Protein, Cyclin-Dependent Kinase Inhibitor p27, DNA Damage, Down-Regulation, Genes, cdc, Humans, Male, Prostatic Neoplasms, Radiation, Retinoblastoma Protein, Retinoblastoma-Like Protein p107, Tumor Suppressor Proteins
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice.
Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA
(2007) Cell 131: 378-90
MeSH Terms: Animals, Bone Marrow Neoplasms, Brain Neoplasms, Cell Differentiation, Cell Division, Interneurons, Lymphatic Metastasis, Mice, Retina, Retinal Neoplasms, Retinoblastoma, Retinoblastoma Protein, Retinoblastoma-Like Protein p107, Stem Cells
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130.
Garriga J, Jayaraman AL, Limón A, Jayadeva G, Sotillo E, Truongcao M, Patsialou A, Wadzinski BE, Graña X
(2004) Cell Cycle 3: 1320-30
MeSH Terms: Antigens, Viral, Tumor, Binding Sites, Cell Cycle, Cell Line, Tumor, Cyclin D1, Cyclin-Dependent Kinases, Humans, Phosphoprotein Phosphatases, Phosphorylation, Protein Binding, Protein Biosynthesis, Retinoblastoma Protein, Retinoblastoma-Like Protein p107, Retinoblastoma-Like Protein p130
Added December 10, 2013
0 Communities
1 Members
0 Resources
14 MeSH Terms
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL
(2002) Mol Cell Biol 22: 8184-98
MeSH Terms: Animals, Antibiotics, Antineoplastic, CDC2-CDC28 Kinases, Carcinoma, Cell Cycle Proteins, Cell Division, Cell Line, Cell Transformation, Neoplastic, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinases, Cyclins, DNA-Binding Proteins, E2F4 Transcription Factor, Enzyme Inhibitors, Epithelial Cells, Genes, Reporter, Growth Inhibitors, Humans, Nuclear Proteins, Phosphoproteins, Protein Binding, Protein Serine-Threonine Kinases, Proteins, Retinoblastoma Protein, Retinoblastoma-Like Protein p107, Retinoblastoma-Like Protein p130, Signal Transduction, Sirolimus, Tacrolimus Binding Proteins, Transcription Factors, Transforming Growth Factor beta, Tumor Suppressor Proteins
Added February 17, 2014
0 Communities
1 Members
0 Resources
34 MeSH Terms
E2F-independent transcriptional repression by p107, a member of the retinoblastoma family of proteins.
Dagnino L, Zhu L, Skorecki KL, Moses HL
(1995) Cell Growth Differ 6: 191-8
MeSH Terms: Carrier Proteins, Cell Cycle Proteins, DNA-Binding Proteins, E2F Transcription Factors, Genes, Retinoblastoma, Genes, myc, HeLa Cells, Humans, Multigene Family, Nuclear Proteins, Promoter Regions, Genetic, Repressor Proteins, Retinoblastoma-Binding Protein 1, Retinoblastoma-Like Protein p107, TATA Box, Transcription Factor DP1, Transcription Factors, Tumor Cells, Cultured, Viral Proteins
Added February 17, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.
Hoang AT, Lutterbach B, Lewis BC, Yano T, Chou TY, Barrett JF, Raffeld M, Hann SR, Dang CV
(1995) Mol Cell Biol 15: 4031-42
MeSH Terms: Alleles, Amino Acid Sequence, Base Sequence, Burkitt Lymphoma, Cell Transformation, Neoplastic, Cyclins, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Genes, myc, Humans, Models, Genetic, Molecular Sequence Data, Mutation, Nuclear Proteins, Phosphorylation, Protein Binding, Proto-Oncogene Proteins c-myc, Retinoblastoma-Like Protein p107, Structure-Activity Relationship, Suppression, Genetic, TATA-Box Binding Protein, Threonine, Transcription Factors, Transcriptional Activation
Added March 20, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms