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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 20

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Sigma-1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors.
Brindley RL, Bauer MB, Hartley ND, Horning KJ, Currie KPM
(2017) J Neurochem 143: 171-182
MeSH Terms: Adrenal Medulla, Animals, Anisoles, Catecholamines, Cattle, Cells, Cultured, Chromaffin Cells, Dose-Response Relationship, Drug, Ligands, Male, Mice, Mice, Inbred C57BL, Nicotinic Antagonists, Propylamines, Receptors, Nicotinic, Receptors, sigma
Added September 28, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Role of sigma-1 receptors in neurodegenerative diseases.
Nguyen L, Lucke-Wold BP, Mookerjee SA, Cavendish JZ, Robson MJ, Scandinaro AL, Matsumoto RR
(2015) J Pharmacol Sci 127: 17-29
MeSH Terms: Animals, Humans, Models, Biological, Molecular Targeted Therapy, Nerve Degeneration, Neurodegenerative Diseases, Neuroprotective Agents, Receptors, sigma
Added August 26, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms
Sigma receptors as potential therapeutic targets for neuroprotection.
Nguyen L, Kaushal N, Robson MJ, Matsumoto RR
(2014) Eur J Pharmacol 743: 42-7
MeSH Terms: Animals, Humans, Ligands, Neurodegenerative Diseases, Neuroprotective Agents, Receptors, sigma
Added August 26, 2015
0 Communities
1 Members
0 Resources
6 MeSH Terms
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR
(2014) PLoS One 9: e89985
MeSH Terms: Adrenergic alpha-Antagonists, Animals, Antidepressive Agents, Behavior, Animal, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dextromethorphan, Dose-Response Relationship, Drug, Ethylenediamines, Excitatory Amino Acid Antagonists, Ketamine, Kinetics, Male, Mice, Piperazines, Protein Binding, Quinidine, Receptors, N-Methyl-D-Aspartate, Receptors, sigma, Swimming
Added August 26, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.
Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR
(2014) Exp Neurol 254: 180-9
MeSH Terms: Animals, Astrocytes, Benzoxazoles, Central Nervous System Stimulants, Corpus Striatum, Cytokine Receptor gp130, Dopaminergic Neurons, Drug Interactions, Fever, Glial Fibrillary Acidic Protein, Gliosis, Male, Methamphetamine, Mice, Oncostatin M Receptor beta Subunit, Phosphorylation, Piperazines, Receptors, sigma, STAT3 Transcription Factor, Signal Transduction
Added August 26, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Sigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects.
Matsumoto RR, Nguyen L, Kaushal N, Robson MJ
(2014) Adv Pharmacol 69: 323-86
MeSH Terms: Animals, Central Nervous System Stimulants, Clinical Trials as Topic, Cocaine, Drug Delivery Systems, Humans, Methamphetamine, Opipramol, Protein Binding, Receptors, sigma, Substance-Related Disorders
Added August 26, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.
Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR
(2014) Eur J Pharmacol 724: 193-203
MeSH Terms: Animals, Apoptosis, Benzoxazoles, Caspases, Cell Line, Tumor, Fever, Ligands, Methamphetamine, Mice, Necrosis, Neuroprotective Agents, Piperazines, Reactive Nitrogen Species, Reactive Oxygen Species, Receptors, sigma, eIF-2 Kinase
Added August 26, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.
Robson MJ, Seminerio MJ, McCurdy CR, Coop A, Matsumoto RR
(2013) Pharmacol Rep 65: 343-9
MeSH Terms: Animals, Benzothiazoles, Body Temperature, Corpus Striatum, Dopamine, Dopamine Agents, Fever, Male, Methamphetamine, Mice, Neurotoxicity Syndromes, Oxalates, Piperazines, Piperidines, Receptors, sigma
Added July 10, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.
Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR
(2013) Exp Neurol 247: 134-42
MeSH Terms: Analysis of Variance, Animals, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Benzoxazoles, Body Temperature, Brain, Cytokines, Male, Methamphetamine, Mice, Microglia, Piperazines, RNA, Messenger, Receptors, sigma, Time Factors, Up-Regulation
Added July 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.
Kaushal N, Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR
(2013) Eur Neuropsychopharmacol 23: 960-71
MeSH Terms: Animals, Benzoxazoles, Central Nervous System Stimulants, Corpus Striatum, Dopamine, Dopamine Antagonists, Dopamine Plasma Membrane Transport Proteins, Drug Synergism, Fever, Guanidines, Male, Methamphetamine, Mice, Nerve Tissue Proteins, Neurons, Neuroprotective Agents, Neurotoxicity Syndromes, Piperazines, Random Allocation, Receptors, sigma, Serotonin, Serotonin Antagonists, Serotonin Plasma Membrane Transport Proteins
Added July 10, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms