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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity.
Finnberg NK, Gokare P, Navaraj A, Lang Kuhs KA, Cerniglia G, Yagita H, Takeda K, Motoyama N, El-Deiry WS
(2016) Cancer Res 76: 700-12
MeSH Terms: Animals, Antibodies, Monoclonal, Apoptosis, Cell Death, Cell Line, Tumor, DNA Damage, Female, Gastrointestinal Diseases, Humans, Intestinal Mucosa, Intestines, Male, Mice, Mice, Transgenic, Receptors, TNF-Related Apoptosis-Inducing Ligand, Stem Cells
Added August 15, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models.
Liu Y, Hawkins OE, Vilgelm AE, Pawlikowski JS, Ecsedy JA, Sosman JA, Kelley MC, Richmond A
(2015) Clin Cancer Res 21: 5338-48
MeSH Terms: Animals, Antibodies, Monoclonal, Antineoplastic Agents, Apoptosis, Aurora Kinases, Azepines, Caspases, Cell Line, Tumor, Cellular Senescence, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Humans, Melanoma, Mice, Protein Kinase Inhibitors, Pyrimidines, Receptors, Death Domain, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Member 10c, Signal Transduction, TNF-Related Apoptosis-Inducing Ligand, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays
Added August 21, 2015
2 Communities
3 Members
0 Resources
24 MeSH Terms
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
He K, Zheng X, Li M, Zhang L, Yu J
(2016) Oncogene 35: 148-57
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Apoptosis, Cell Cycle Proteins, Cell Line, Tumor, Colonic Neoplasms, Everolimus, Female, Humans, Mice, Nude, Phosphoproteins, Phosphorylation, Protein Kinase Inhibitors, Receptors, TNF-Related Apoptosis-Inducing Ligand, Sirolimus, TOR Serine-Threonine Kinases, Transcription Factor CHOP, Xenograft Model Antitumor Assays
Added July 28, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency.
Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Barbier-Torres L, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Beraza N
(2015) Lab Invest 95: 223-36
MeSH Terms: Amino Acid Metabolism, Inborn Errors, Animals, Bile Ducts, Blotting, Western, End Stage Liver Disease, Flow Cytometry, Glycine N-Methyltransferase, Humans, Immunohistochemistry, Killer Cells, Natural, Ligation, Mice, Mice, Knockout, Receptors, TNF-Related Apoptosis-Inducing Ligand, TNF-Related Apoptosis-Inducing Ligand
Added January 20, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.
Oh YT, Yue P, Zhou W, Balko JM, Black EP, Owonikoko TK, Khuri FR, Sun SY
(2012) J Biol Chem 287: 257-267
MeSH Terms: Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Neoplastic, Humans, JNK Mitogen-Activated Protein Kinases, Mutation, Promoter Regions, Genetic, Proto-Oncogene Proteins B-raf, Receptors, TNF-Related Apoptosis-Inducing Ligand, Ribosomal Protein S6 Kinases, Signal Transduction, Transcription Factor CHOP, Transcription, Genetic, ets-Domain Protein Elk-1, ras Proteins
Added March 10, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Bid regulates the pathogenesis of neurotropic reovirus.
Danthi P, Pruijssers AJ, Berger AK, Holm GH, Zinkel SS, Dermody TS
(2010) PLoS Pathog 6: e1000980
MeSH Terms: Animals, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Encephalitis, Viral, Fas-Associated Death Domain Protein, Fibroblasts, Humans, L Cells, Mice, NF-kappa B, Receptors, TNF-Related Apoptosis-Inducing Ligand, Reoviridae, Reoviridae Infections, Signal Transduction, Virus Replication
Added December 10, 2013
1 Communities
2 Members
0 Resources
15 MeSH Terms
IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expression.
Yang D, Wang S, Brooks C, Dong Z, Schoenlein PV, Kumar V, Ouyang X, Xiong H, Lahat G, Hayes-Jordan A, Lazar A, Pollock R, Lev D, Liu K
(2009) Cancer Res 69: 1080-8
MeSH Terms: Animals, Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspase 8, Caspase Inhibitors, Cell Line, Tumor, Enzyme Activation, Fas Ligand Protein, Humans, Immunohistochemistry, Interferon Regulatory Factors, Mice, Mitochondria, RNA, Messenger, RNA, Small Interfering, Receptors, TNF-Related Apoptosis-Inducing Ligand, Sarcoma, Sarcoma, Experimental, TNF-Related Apoptosis-Inducing Ligand
Added September 12, 2016
0 Communities
1 Members
0 Resources
19 MeSH Terms
Expression of Keratin 8 and TNF-Related Apoptosis-I Inducing Ligand (TRAIL) in Down Syndrome Placentas.
Klugman SD, Gross SJ, Liang J, Livne K, Gross B, Khabele D, Lopez-Jones M, Cordero DR, Reznik S
(2008) Placenta 29: 382-4
MeSH Terms: Blotting, Northern, Cell Membrane, Down Syndrome, Female, GPI-Linked Proteins, Gene Expression Profiling, Humans, Immunohistochemistry, Karyotyping, Keratin-8, Placenta, Pregnancy, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Member 10c, TNF-Related Apoptosis-Inducing Ligand, Trophoblasts, Tumor Necrosis Factor Decoy Receptors, Tumor Necrosis Factor-alpha
Added March 5, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cells.
Nastiuk KL, Yoo K, Lo K, Su K, Yeung P, Kutaka J, Danielpour D, Krolewski JJ
(2008) Mol Cancer Res 6: 231-42
MeSH Terms: Animals, Apoptosis, CASP8 and FADD-Like Apoptosis Regulating Protein, Caspases, Cell Differentiation, Cell Line, Cell Survival, Enzyme Activation, Epithelial Cells, Etanercept, Fas Ligand Protein, Gene Expression Regulation, Humans, Immunoglobulin G, Insulin, Male, Mice, Prostate, RNA, Messenger, Rats, Receptors, TNF-Related Apoptosis-Inducing Ligand, Receptors, Tumor Necrosis Factor, Solubility, Transfection, Transforming Growth Factor beta1
Added April 7, 2010
0 Communities
1 Members
0 Resources
25 MeSH Terms
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding.
Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R, Thorburn A
(2007) J Biol Chem 282: 28189-94
MeSH Terms: Binding, Competitive, Cell Line, Tumor, Dose-Response Relationship, Drug, Electroporation, Gene Expression Regulation, Neoplastic, Humans, Ligands, Models, Biological, Mutation, Neoplasms, Protein Binding, Receptors, TNF-Related Apoptosis-Inducing Ligand, Signal Transduction, Subcellular Fractions
Added May 27, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms