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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways.
Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM
(2019) PLoS One 14: e0220893
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Cell Membrane, Endothelial Cells, Humans, Inflammation, Intracellular Signaling Peptides and Proteins, Phosphorylation, Protein Serine-Threonine Kinases, Rats, Receptors, Purinergic P2X7, Saline Solution, Saphenous Vein, Signal Transduction, Swine, p38 Mitogen-Activated Protein Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Mechanosensitive Ion Channels: TRPV4 and P2X7 in Disseminating Cancer Cells.
Hope JM, Greenlee JD, King MR
(2018) Cancer J 24: 84-92
MeSH Terms: Animals, Cell Movement, Humans, Mechanotransduction, Cellular, Neoplasms, Receptors, Purinergic P2X7, TRPV Cation Channels
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.
Komalavilas P, Luo W, Guth CM, Jolayemi O, Bartelson RI, Cheung-Flynn J, Brophy CM
(2017) PLoS One 12: e0188069
MeSH Terms: Animals, Endothelium, Vascular, Female, Nitric Oxide, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Vascular Surgical Procedures, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis.
Luo W, Feldman D, McCallister R, Brophy C, Cheung-Flynn J
(2017) Purinergic Signal 13: 579-590
MeSH Terms: Animals, Aorta, Apoptosis, Coronary Artery Bypass, Female, Humans, Male, Purinergic P2X Receptor Antagonists, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Saphenous Vein, Specimen Handling
Added May 22, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Adenosine triphosphate as a molecular mediator of the vascular response to injury.
Guth CM, Luo W, Jolayemi O, Chadalavada KS, Komalavilas P, Cheung-Flynn J, Brophy CM
(2017) J Surg Res 216: 80-86
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Abdominal, Biomarkers, Biomechanical Phenomena, Blotting, Western, Female, Muscle Contraction, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Stress, Mechanical, Vascular System Injuries, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.
Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J
(2016) J Vasc Surg 64: 471-478
MeSH Terms: Animals, Benzenesulfonates, Cell Line, Cell Movement, Cell Proliferation, Coloring Agents, Humans, Hyperplasia, Jugular Veins, Models, Animal, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Neointima, Organ Culture Techniques, Purinergic P2X Receptor Antagonists, Rabbits, Rats, Receptors, Purinergic P2X7, Saphenous Vein, Signal Transduction, Time Factors, Tissue and Organ Harvesting
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.
Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J
(2016) J Vasc Surg 64: 210-8
MeSH Terms: Animals, Aorta, Benzenesulfonates, Calcium Signaling, Cells, Cultured, Coloring Agents, Cytoprotection, Female, Human Umbilical Vein Endothelial Cells, Humans, Hyperplasia, In Vitro Techniques, Male, Neointima, Organ Culture Techniques, Purinergic P2X Receptor Antagonists, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Saphenous Vein, Swine, Vascular Grafting, Vascular System Injuries, Vasoconstriction
Added March 9, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms
Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages.
da Silva-Souza HA, Lira MN, Costa-Junior HM, da Cruz CM, Vasconcellos JS, Mendes AN, Pimenta-Reis G, Alvarez CL, Faccioli LH, Serezani CH, Schachter J, Persechini PM
(2014) Biochim Biophys Acta 1838: 1967-77
MeSH Terms: Adenosine Triphosphate, Animals, Arachidonate 5-Lipoxygenase, Calcium, Cations, Ion Transport, Lipoxygenase Inhibitors, Macrophages, Mice, Mice, Inbred C57BL, Phospholipases A2, Receptors, Purinergic P2X7
Added May 4, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Blocking the P2X7 receptor improves outcomes after axonal fusion.
Rodriguez-Feo CL, Sexton KW, Boyer RB, Pollins AC, Cardwell NL, Nanney LB, Shack RB, Mikesh MA, McGill CH, Driscoll CW, Bittner GD, Thayer WP
(2013) J Surg Res 184: 705-13
MeSH Terms: Action Potentials, Adenosine Triphosphate, Animals, Axons, Benzenesulfonates, Coloring Agents, Drug Carriers, Male, Motor Activity, Nerve Regeneration, Neurosurgical Procedures, Platelet Aggregation Inhibitors, Polyethylene Glycols, Purinergic P2X Receptor Antagonists, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Sciatic Neuropathy, Wallerian Degeneration, Wound Healing
Added July 9, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms