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Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways.
Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM
(2019) PLoS One 14: e0220893
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Cell Membrane, Endothelial Cells, Humans, Inflammation, Intracellular Signaling Peptides and Proteins, Phosphorylation, Protein Serine-Threonine Kinases, Rats, Receptors, Purinergic P2X7, Saline Solution, Saphenous Vein, Signal Transduction, Swine, p38 Mitogen-Activated Protein Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).
Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR, ICPC Investigators
(2018) Am Heart J 198: 152-159
MeSH Terms: Acute Coronary Syndrome, Aged, Clopidogrel, Female, Genetic Association Studies, Genome-Wide Association Study, Humans, Internationality, Male, Middle Aged, Molecular Targeted Therapy, Pharmacogenetics, Prognosis, Receptors, Purinergic P2Y12, Risk Assessment, Survival Rate, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Mechanosensitive Ion Channels: TRPV4 and P2X7 in Disseminating Cancer Cells.
Hope JM, Greenlee JD, King MR
(2018) Cancer J 24: 84-92
MeSH Terms: Animals, Cell Movement, Humans, Mechanotransduction, Cellular, Neoplasms, Receptors, Purinergic P2X7, TRPV Cation Channels
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.
Komalavilas P, Luo W, Guth CM, Jolayemi O, Bartelson RI, Cheung-Flynn J, Brophy CM
(2017) PLoS One 12: e0188069
MeSH Terms: Animals, Endothelium, Vascular, Female, Nitric Oxide, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Vascular Surgical Procedures, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis.
Luo W, Feldman D, McCallister R, Brophy C, Cheung-Flynn J
(2017) Purinergic Signal 13: 579-590
MeSH Terms: Animals, Aorta, Apoptosis, Coronary Artery Bypass, Female, Humans, Male, Purinergic P2X Receptor Antagonists, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Saphenous Vein, Specimen Handling
Added May 22, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
Adenosine triphosphate as a molecular mediator of the vascular response to injury.
Guth CM, Luo W, Jolayemi O, Chadalavada KS, Komalavilas P, Cheung-Flynn J, Brophy CM
(2017) J Surg Res 216: 80-86
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Abdominal, Biomarkers, Biomechanical Phenomena, Blotting, Western, Female, Muscle Contraction, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Stress, Mechanical, Vascular System Injuries, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Prostaglandin E glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y.
Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T
(2017) Sci Rep 7: 2380
MeSH Terms: Animals, Binding Sites, Cell Line, Tumor, Cyclooxygenase 2, Dinoprostone, HEK293 Cells, High-Throughput Nucleotide Sequencing, High-Throughput Screening Assays, Humans, Kinetics, Ligands, Mice, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Purinergic Agonists, RAW 264.7 Cells, Receptors, Purinergic P2, Substrate Specificity, Thermodynamics, Transcriptome
Added March 17, 2018
0 Communities
2 Members
0 Resources
23 MeSH Terms
Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.
Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J
(2016) J Vasc Surg 64: 471-478
MeSH Terms: Animals, Benzenesulfonates, Cell Line, Cell Movement, Cell Proliferation, Coloring Agents, Humans, Hyperplasia, Jugular Veins, Models, Animal, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Neointima, Organ Culture Techniques, Purinergic P2X Receptor Antagonists, Rabbits, Rats, Receptors, Purinergic P2X7, Saphenous Vein, Signal Transduction, Time Factors, Tissue and Organ Harvesting
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Integrated compensatory network is activated in the absence of NCC phosphorylation.
Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA
(2015) J Clin Invest 125: 2136-50
MeSH Terms: Amiloride, Ammonia, Animals, Biological Transport, Blood Pressure, Carbonic Anhydrases, Chlorides, Disease Models, Animal, Enzyme Activation, Epithelial Sodium Channels, Gene Expression Profiling, Gene Regulatory Networks, Gitelman Syndrome, Ketoglutaric Acids, Kidney Glomerulus, Male, Mice, Mice, Knockout, Natriuresis, Nephrons, Paracrine Communication, Phosphorylation, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases, Receptors, Notch, Receptors, Purinergic P2, Renal Reabsorption, Signal Transduction, Sodium Chloride, Sodium-Potassium-Chloride Symporters, Solute Carrier Family 12, Member 3
Added May 3, 2017
0 Communities
1 Members
0 Resources
31 MeSH Terms
Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.
Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J
(2016) J Vasc Surg 64: 210-8
MeSH Terms: Animals, Aorta, Benzenesulfonates, Calcium Signaling, Cells, Cultured, Coloring Agents, Cytoprotection, Female, Human Umbilical Vein Endothelial Cells, Humans, Hyperplasia, In Vitro Techniques, Male, Neointima, Organ Culture Techniques, Purinergic P2X Receptor Antagonists, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Saphenous Vein, Swine, Vascular Grafting, Vascular System Injuries, Vasoconstriction
Added March 9, 2015
0 Communities
2 Members
0 Resources
23 MeSH Terms