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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running.
Ruegsegger GN, Brown JD, Kovarik MC, Miller DK, Booth FW
(2016) Neuroscience 339: 525-537
MeSH Terms: Animals, Cells, Cultured, Dopamine, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Feeding Behavior, Female, Injections, Intraperitoneal, Motivation, Motor Activity, Naltrexone, Narcotic Antagonists, Neurons, Nucleus Accumbens, Oxidopamine, RNA, Messenger, Rats, Receptors, Opioid, mu, Running, Sedentary Behavior, Species Specificity, Volition
Added October 23, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.
Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E
(2013) J Neurochem 124: 189-99
MeSH Terms: 5' Flanking Region, Amino Acid Sequence, Animals, HEK293 Cells, Humans, Molecular Sequence Data, Phosphorylation, Protein Kinases, Protein Structure, Tertiary, Protein Transport, Rats, Receptors, Opioid, mu
Added February 12, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
Total synthesis and biological evaluation of phidianidines A and B uncovers unique pharmacological profiles at CNS targets.
Brogan JT, Stoops SL, Lindsley CW
(2012) ACS Chem Neurosci 3: 658-64
MeSH Terms: Animals, CHO Cells, Cell Proliferation, Cell Survival, Central Nervous System Agents, Chromatography, High Pressure Liquid, Cricetinae, Cricetulus, Dopamine Plasma Membrane Transport Proteins, Gastropoda, Guanosine 5'-O-(3-Thiotriphosphate), HEK293 Cells, Humans, Indicators and Reagents, Indole Alkaloids, Ligands, Oxadiazoles, Radioligand Assay, Receptors, Opioid, mu, Serotonin Plasma Membrane Transport Proteins, Structure-Activity Relationship
Added March 7, 2014
1 Communities
1 Members
0 Resources
21 MeSH Terms
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
Miller M, Shi J, Zhu Y, Kustov M, Tian JB, Stevens A, Wu M, Xu J, Long S, Yang P, Zholos AV, Salovich JM, Weaver CD, Hopkins CR, Lindsley CW, McManus O, Li M, Zhu MX
(2011) J Biol Chem 286: 33436-46
MeSH Terms: Animals, Cations, Female, Fluorescent Dyes, HEK293 Cells, High-Throughput Screening Assays, Humans, Indoles, Intestines, Ion Channel Gating, Male, Mice, Mice, Inbred C57BL, Myocytes, Smooth Muscle, Piperidines, Receptors, Muscarinic, Receptors, Opioid, mu, Structure-Activity Relationship, TRPC Cation Channels
Added February 16, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
The mu opioid receptor A118G gene polymorphism moderates effects of trait anger-out on acute pain sensitivity.
Bruehl S, Chung OY, Burns JW
(2008) Pain 139: 406-415
MeSH Terms: Adult, Anger, Female, Humans, Inhibition, Psychological, Male, Pain, Pain Measurement, Pain Threshold, Polymorphism, Single Nucleotide, Receptors, Opioid, mu
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Anger regulation style, postoperative pain, and relationship to the A118G mu opioid receptor gene polymorphism: a preliminary study.
Bruehl S, Chung OY, Donahue BS, Burns JW
(2006) J Behav Med 29: 161-9
MeSH Terms: Adult, Alleles, Anger, Female, Humans, Male, Middle Aged, Pain Measurement, Pain, Postoperative, Polymorphism, Single Nucleotide, Prospective Studies, Racial Groups, Receptors, Opioid, mu, Social Control, Informal, Surveys and Questionnaires
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis.
Kelly MJ, Rønnekleiv OK, Ibrahim N, Lagrange AH, Wagner EJ
(2002) Steroids 67: 447-56
MeSH Terms: Animals, Electrodes, Estrogens, Female, GTP-Binding Proteins, Guinea Pigs, Hypothalamus, Neurons, Patch-Clamp Techniques, Potassium Channels, Calcium-Activated, Protein Kinases, Receptors, Cell Surface, Receptors, GABA, Receptors, Opioid, mu, Reproduction
Added August 14, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin.
Lowe JD, Celver JP, Gurevich VV, Chavkin C
(2002) J Biol Chem 277: 15729-35
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Animals, Arrestin, Arrestins, Cloning, Molecular, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Enkephalin, D-Penicillamine (2,5)-, G-Protein-Coupled Receptor Kinase 3, GTP-Binding Proteins, Kinetics, Mice, Models, Molecular, Mutagenesis, Site-Directed, Oocytes, Phosphoproteins, Phosphorylation, Protein Conformation, Protein Serine-Threonine Kinases, Receptors, Opioid, delta, Receptors, Opioid, mu, Recombinant Proteins, Threonine, Xenopus laevis
Added December 10, 2013
0 Communities
1 Members
0 Resources
24 MeSH Terms
Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes.
Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C
(2001) J Biol Chem 276: 4894-900
MeSH Terms: Animals, Arrestins, Dose-Response Relationship, Drug, Down-Regulation, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, G Protein-Coupled Inwardly-Rectifying Potassium Channels, G-Protein-Coupled Receptor Kinase 3, Mutagenesis, Site-Directed, Oocytes, Phosphothreonine, Potassium Channels, Potassium Channels, Inwardly Rectifying, Protein Serine-Threonine Kinases, Receptors, Opioid, mu, Transfection, Xenopus, beta-Arrestins
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways.
Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK
(1999) Steroids 64: 64-75
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cycloheximide, Enzyme Activation, Enzyme Inhibitors, Estrogens, Female, GTP-Binding Proteins, Guinea Pigs, Hypothalamus, Immunohistochemistry, In Vitro Techniques, Protein Kinase C, Protein Synthesis Inhibitors, Receptors, GABA-B, Receptors, Opioid, mu
Added August 14, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms