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Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo.
Melchior JR, Jones SR
(2017) Mol Cell Neurosci 85: 93-104
MeSH Terms: Alcoholism, Animals, Central Nervous System Depressants, Dopamine, Dopaminergic Neurons, Ethanol, Gene Knock-In Techniques, Male, Mice, Mice, Inbred C57BL, Nucleus Accumbens, Optogenetics, Organ Culture Techniques, Receptors, Opioid, kappa, Synaptic Transmission
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.
Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA
(2016) Proc Natl Acad Sci U S A 113: 6041-6
MeSH Terms: Agaricales, Animals, Antipruritics, Diterpenes, Clerodane, HEK293 Cells, Humans, MAP Kinase Signaling System, Mice, Mice, Knockout, Receptors, Opioid, kappa, Second Messenger Systems
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Locus coeruleus kappa-opioid receptors modulate reinstatement of cocaine place preference through a noradrenergic mechanism.
Al-Hasani R, McCall JG, Foshage AM, Bruchas MR
(2013) Neuropsychopharmacology 38: 2484-97
MeSH Terms: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Adrenergic alpha-2 Receptor Agonists, Adrenergic beta-1 Receptor Antagonists, Adrenergic beta-Antagonists, Animals, Betaxolol, Clonidine, Cocaine, Conditioning, Psychological, Drug-Seeking Behavior, Locus Coeruleus, Male, Mice, Mice, Inbred C57BL, Naltrexone, Propanolamines, Propranolol, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Receptors, Opioid, kappa
Added May 15, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Ligand directed signaling differences between rodent and human κ-opioid receptors.
Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C
(2012) J Biol Chem 287: 41595-607
MeSH Terms: Amino Acid Substitution, Analgesics, Opioid, Animals, Enzyme Activation, HEK293 Cells, Humans, Ligands, MAP Kinase Signaling System, Male, Mice, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mutation, Missense, Phosphorylation, Receptors, Opioid, kappa, Species Specificity, p38 Mitogen-Activated Protein Kinases
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.
Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA
(2011) Biol Psychiatry 70: 425-33
MeSH Terms: Amygdala, Animals, Anxiety, Conditioning, Psychological, Corpus Striatum, Disease Models, Animal, Dynorphins, Extinction, Psychological, Fear, Gene Expression Regulation, Hippocampus, Male, Maze Learning, Microinjections, Piperidines, Rats, Receptors, Opioid, kappa, Reflex, Startle, Signal Transduction, Tetrahydroisoquinolines
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
CHOBIMALT: a cholesterol-based detergent.
Howell SC, Mittal R, Huang L, Travis B, Breyer RM, Sanders CR
(2010) Biochemistry 49: 9572-83
MeSH Terms: Cholesterol, Detergents, Humans, Magnetic Resonance Spectroscopy, Micelles, Models, Molecular, Receptors, Opioid, kappa, Solubility
Added December 21, 2013
0 Communities
2 Members
0 Resources
8 MeSH Terms
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.
Jacobson DA, Cho J, Landa LR, Tamarina NA, Roe MW, Buxbaum JD, Philipson LH
(2006) Am J Physiol Endocrinol Metab 291: E587-95
MeSH Terms: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Animals, Calcium, Cell Line, Cell Nucleus, DNA, Dynorphins, Electrophoretic Mobility Shift Assay, Enkephalins, Gene Expression Regulation, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Insulin-Secreting Cells, Islets of Langerhans, Kv Channel-Interacting Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Naltrexone, Protein Binding, Protein Precursors, Receptors, Opioid, kappa, Repressor Proteins
Added February 12, 2015
0 Communities
1 Members
0 Resources
25 MeSH Terms
Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens.
Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA
(2001) J Neurosci 21: 7397-403
MeSH Terms: Animals, Cocaine, Conditioning, Psychological, Cyclic AMP Response Element-Binding Protein, Dynorphins, Gene Expression, Gene Transfer Techniques, Genes, Dominant, Genetic Vectors, Hypokinesia, Male, Microinjections, Motor Activity, Narcotic Antagonists, Nucleus Accumbens, Rats, Rats, Sprague-Dawley, Reaction Time, Receptors, Opioid, kappa, Simplexvirus, Swimming
Added May 27, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms