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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 45

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Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders.
Teal LB, Gould RW, Felts AS, Jones CK
(2019) Adv Pharmacol 86: 153-196
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Humans, Receptors, Muscarinic, Schizophrenia, Signal Transduction, Substance-Related Disorders
Added March 18, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Discovery and Optimization of Potent and CNS Penetrant M-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.
Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead CJ, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neill JC, Zhan X, Niswender CM, Jones CK, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 1572-1581
MeSH Terms: Allosteric Regulation, Amides, Animals, Brain, Cholinergic Agents, Drug Discovery, Humans, Male, Microsomes, Liver, Molecular Structure, Piperidines, Rats, Sprague-Dawley, Receptors, Muscarinic, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.
Bender AM, Weiner RL, Luscombe VB, Cho HP, Niswender CM, Engers DW, Bridges TM, Conn PJ, Lindsley CW
(2017) Bioorg Med Chem Lett 27: 2479-2483
MeSH Terms: Animals, Brain, Humans, Inhibitory Concentration 50, Muscarinic Antagonists, Protein Binding, Pyrimidines, Rats, Receptor, Muscarinic M4, Receptors, Muscarinic, Recombinant Proteins, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations.
Dean B, Hopper S, Conn PJ, Scarr E
(2016) Neuropsychopharmacology 41: 1620-8
MeSH Terms: Allosteric Regulation, Cations, Divalent, Cerebral Cortex, Female, Humans, Male, Middle Aged, N-Methylscopolamine, Pirenzepine, Quinolines, Receptor, Muscarinic M1, Receptors, Muscarinic, Schizophrenia
Added February 18, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes.
Gimenez LE, Babilon S, Wanka L, Beck-Sickinger AG, Gurevich VV
(2014) Cell Signal 26: 1523-31
MeSH Terms: Animals, Arrestins, COS Cells, Cell Line, Chlorocebus aethiops, Mutation, Protein Binding, Receptors, Adrenergic, beta, Receptors, Dopamine, Receptors, Muscarinic, Receptors, Neuropeptide Y
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.
Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S
(2014) Neuron 81: 1111-1125
MeSH Terms: Amygdala, Animals, Calcium, Endocannabinoids, Excitatory Postsynaptic Potentials, G-Protein-Coupled Receptor Kinase 2, GTP-Binding Protein alpha Subunits, Gq-G11, Glutamic Acid, Male, Mice, Mice, Inbred ICR, Neurons, Receptor Protein-Tyrosine Kinases, Receptor, Cannabinoid, CB1, Receptors, Muscarinic, Signal Transduction, Synapses, Synaptic Transmission
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Gentry PR, Bridges TM, Lamsal A, Vinson PN, Smith E, Chase P, Hodder PS, Engers JL, Niswender CM, Daniels JS, Conn PJ, Wood MR, Lindsley CW
(2013) Bioorg Med Chem Lett 23: 2996-3000
MeSH Terms: Animals, Dose-Response Relationship, Drug, Drug Discovery, Humans, Indoles, Molecular Structure, Rats, Receptors, Muscarinic, Structure-Activity Relationship
Added September 12, 2013
1 Communities
3 Members
0 Resources
9 MeSH Terms
Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling.
Foster DJ, Jones CK, Conn PJ
(2012) Discov Med 14: 413-20
MeSH Terms: Allosteric Regulation, Animals, Cholinergic Neurons, Humans, Receptors, Muscarinic, Receptors, Nicotinic, Schizophrenia, Signal Transduction
Added February 19, 2015
0 Communities
2 Members
0 Resources
8 MeSH Terms
Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
Sheffler DJ, Sevel C, Le U, Lovell KM, Tarr JC, Carrington SJ, Cho HP, Digby GJ, Niswender CM, Conn PJ, Hopkins CR, Wood MR, Lindsley CW
(2013) Bioorg Med Chem Lett 23: 223-7
MeSH Terms: Acetylcholine, Allosteric Regulation, Allosteric Site, Animals, Benzamides, Benzimidazoles, CHO Cells, Calcium, Cricetinae, Cricetulus, Humans, Piperidines, Rats, Receptor, Muscarinic M1, Receptors, Muscarinic, Structure-Activity Relationship, Transfection
Added March 7, 2014
1 Communities
3 Members
0 Resources
17 MeSH Terms
Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor.
Melancon BJ, Gogliotti RD, Tarr JC, Saleh SA, Chauder BA, Lebois EP, Cho HP, Utley TJ, Sheffler DJ, Bridges TM, Morrison RD, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Wood MR
(2012) Bioorg Med Chem Lett 22: 3467-72
MeSH Terms: Humans, Molecular Probes, Receptors, Muscarinic
Added February 19, 2015
0 Communities
2 Members
0 Resources
3 MeSH Terms