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Low-density lipoprotein receptor is required for cholesteryl ester transfer protein to regulate triglyceride metabolism in both male and female mice.
Palmisano BT, Yu S, Neuman JC, Zhu L, Luu T, Stafford JM
(2021) Physiol Rep 9: e14732
MeSH Terms: Animals, Cholesterol Ester Transfer Proteins, Female, Genotype, Liver, Male, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Receptors, LDL, Sex Characteristics, Sex Factors, Triglycerides
Added November 11, 2021
0 Communities
1 Members
0 Resources
13 MeSH Terms
Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore.
Anderson DM, Sheedlo MJ, Jensen JL, Lacy DB
(2020) Nat Microbiol 5: 102-107
MeSH Terms: ADP Ribose Transferases, Bacterial Proteins, Bacterial Toxins, Caco-2 Cells, Cryoelectron Microscopy, Humans, Models, Molecular, Polysaccharides, Pore Forming Cytotoxic Proteins, Protein Binding, Protein Domains, Protein Multimerization, Receptors, LDL
Added March 24, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
CD8 T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease.
Breuer DA, Pacheco MC, Washington MK, Montgomery SA, Hasty AH, Kennedy AJ
(2020) Am J Physiol Gastrointest Liver Physiol 318: G211-G224
MeSH Terms: Animals, CD8-Positive T-Lymphocytes, Hepatic Stellate Cells, Hepatitis, Humans, Hyperlipidemias, Interleukin-10, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Non-alcoholic Fatty Liver Disease, Obesity, Receptors, LDL
Added March 3, 2020
0 Communities
1 Members
0 Resources
15 MeSH Terms
Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor Mice Improves Indices of Cardiometabolic Disease.
May-Zhang LS, Chen Z, Dosoky NS, Yancey PG, Boyd KL, Hasty AH, Linton MF, Davies SS
(2019) Sci Rep 9: 420
MeSH Terms: Animals, Cardiovascular Diseases, Escherichia coli, Fatty Acids, Gastrointestinal Microbiome, Liver, Liver Cirrhosis, Mice, Phosphatidylethanolamines, Receptors, LDL, Triglycerides
Added January 30, 2019
1 Communities
4 Members
0 Resources
11 MeSH Terms
Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.
Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H
(2019) Circ Res 124: e6-e19
MeSH Terms: Adaptor Proteins, Vesicular Transport, Animals, Apolipoproteins E, Atherosclerosis, Cells, Cultured, Down-Regulation, Gene Deletion, HEK293 Cells, Humans, Low Density Lipoprotein Receptor-Related Protein-1, Macrophages, Mice, Myeloid Cells, RAW 264.7 Cells, Receptors, LDL, Tumor Suppressor Proteins, Ubiquitination
Added April 10, 2019
0 Communities
1 Members
0 Resources
17 MeSH Terms
Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice.
Babaev VR, Ding L, Zhang Y, May JM, Ramsey SA, Vickers KC, Linton MF
(2019) Arterioscler Thromb Vasc Biol 39: 156-169
MeSH Terms: Animals, Atherosclerosis, Cell Survival, Female, Hematopoietic System, Macrophages, Male, Mice, Mice, Inbred C57BL, Monocytes, Protein Isoforms, Proto-Oncogene Proteins c-akt, Receptors, LDL
Added April 10, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.
Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ, Convened by the Familial Hypercholesterolemia Foundation
(2018) J Am Coll Cardiol 72: 662-680
MeSH Terms: Apolipoproteins B, Expert Testimony, Genetic Counseling, Genetic Testing, Humans, Hyperlipoproteinemia Type II, Proprotein Convertase 9, Receptors, LDL
Added April 10, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S
(2018) Circulation 138: 1850-1863
MeSH Terms: Animals, Aorta, Aortic Diseases, Apoptosis, Atherosclerosis, Cells, Cultured, Cholesterol, Disease Models, Animal, Female, Gene Deletion, Genetic Predisposition to Disease, Low Density Lipoprotein Receptor-Related Protein-1, Macrophages, Mice, Knockout, ApoE, Necrosis, Phenotype, Plaque, Atherosclerotic, Receptors, CCR7, Receptors, LDL, Signal Transduction, Tumor Suppressor Proteins, Up-Regulation
Added July 20, 2018
1 Communities
2 Members
0 Resources
22 MeSH Terms
Loss of in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice.
Babaev VR, Huang J, Ding L, Zhang Y, May JM, Linton MF
(2018) Front Immunol 9: 215
MeSH Terms: Animals, Aorta, Atherosclerosis, Cell Proliferation, Cell Survival, Diet, Western, Disease Models, Animal, Female, Humans, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Monocytes, Rapamycin-Insensitive Companion of mTOR Protein, Receptors, LDL
Added April 10, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms
Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling.
Vogel ME, Idelman G, Konaniah ES, Zucker SD
(2017) J Am Heart Assoc 6:
MeSH Terms: Animals, Antioxidants, Aorta, Bilirubin, Cell Movement, Collagen, Diet, Western, Intercellular Adhesion Molecule-1, Lipid Metabolism, Lymphocytes, Male, Mice, Mice, Knockout, Monocytes, Plaque, Atherosclerotic, Receptors, LDL, Signal Transduction, Vascular Cell Adhesion Molecule-1
Added April 27, 2017
0 Communities
1 Members
0 Resources
18 MeSH Terms