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Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network.
Kang Q, Hu M, Jia J, Bai X, Liu C, Wu Z, Chen W, Li M
(2020) Int J Mol Sci 21:
MeSH Terms: Animals, Gene Expression Profiling, Glucose, Liver, Metabolic Networks and Pathways, Receptors, Glucagon, Signal Transduction, Transcriptome, Zebrafish
Added September 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Hepatic Gi signaling regulates whole-body glucose homeostasis.
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J
(2018) J Clin Invest 128: 746-759
MeSH Terms: Animals, Blood Glucose, Extracellular Signal-Regulated MAP Kinases, Female, GTP-Binding Protein alpha Subunits, Gi-Go, Gene Expression Profiling, Glucagon, Gluconeogenesis, Glucose, Hepatocytes, Homeostasis, Humans, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxygen, Phosphatidylinositol 3-Kinases, Phosphorylation, Reactive Oxygen Species, Receptors, Glucagon, Signal Transduction
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Hepatic β-arrestin 2 is essential for maintaining euglycemia.
Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J
(2017) J Clin Invest 127: 2941-2945
MeSH Terms: Animals, Blood Glucose, COS Cells, Chlorocebus aethiops, Diabetes Mellitus, Type 2, Diet, High-Fat, Gene Deletion, Gene Expression Regulation, Glucagon, Hepatocytes, Homeostasis, Insulin, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Receptors, Glucagon, Signal Transduction, beta-Arrestin 1, beta-Arrestin 2
Added March 14, 2018
0 Communities
1 Members
0 Resources
22 MeSH Terms
Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.
Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL
(2016) Elife 5:
MeSH Terms: Animals, Diabetes Mellitus, Experimental, Gastrointestinal Agents, Glucagon, Insulin, Insulin-Secreting Cells, Mice, Mice, Knockout, Receptors, Glucagon, Signal Transduction
Added July 16, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish.
Li M, Dean ED, Zhao L, Nicholson WE, Powers AC, Chen W
(2015) J Endocrinol 227: 93-103
MeSH Terms: Animals, Animals, Genetically Modified, Cell Proliferation, Cloning, Molecular, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, Gene Silencing, Glucagon-Secreting Cells, Hyperplasia, Receptors, Glucagon, Zebrafish
Added February 6, 2016
0 Communities
3 Members
0 Resources
11 MeSH Terms
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW
(2014) J Med Chem 57: 10192-7
MeSH Terms: Allosteric Regulation, Animals, Catalepsy, Central Nervous System Agents, Drug Synergism, Exenatide, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Haloperidol, High-Throughput Screening Assays, Indoles, Insulin, Insulin Secretion, Islets of Langerhans, Male, Mice, Inbred C57BL, Microsomes, Liver, Peptides, Pyrrolidines, Receptors, Glucagon, Structure-Activity Relationship, Venoms
Added February 16, 2015
0 Communities
4 Members
0 Resources
22 MeSH Terms
A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.
Morris LC, Days EL, Turney M, Mi D, Lindsley CW, Weaver CD, Niswender KD
(2014) J Biomol Screen 19: 847-58
MeSH Terms: Allosteric Regulation, Allosteric Site, Animals, Binding Sites, CHO Cells, Calcium, Cell Line, Cell Line, Tumor, Cricetinae, Cricetulus, Cyclic AMP, Disease Progression, Exenatide, Glucagon-Like Peptide 1, Glucose, High-Throughput Screening Assays, Humans, Liraglutide, Peptides, Receptors, Glucagon, Recombinant Proteins, Signal Transduction, Venoms
Added August 14, 2014
0 Communities
3 Members
0 Resources
23 MeSH Terms
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Fujita H, Morii T, Fujishima H, Sato T, Shimizu T, Hosoba M, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y
(2014) Kidney Int 85: 579-89
MeSH Terms: Animals, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Diabetic Nephropathies, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Kidney Glomerulus, Liraglutide, Male, Mice, Inbred C57BL, NADPH Oxidases, Nitric Oxide, Oxidative Stress, Receptors, Glucagon, Signal Transduction
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog.
Moore MC, Werner U, Smith MS, Farmer TD, Cherrington AD
(2013) Am J Physiol Endocrinol Metab 305: E1473-82
MeSH Terms: Acetaminophen, Animals, Consciousness, Dogs, Female, Gastric Emptying, Glucagon, Glucagon-Like Peptide-1 Receptor, Glucose, Hypoglycemic Agents, Insulin, Liver, Male, Peptides, Postprandial Period, Receptors, Glucagon
Added June 2, 2014
0 Communities
3 Members
1 Resources
16 MeSH Terms
Protection of glucagon-like peptide-1 in cisplatin-induced renal injury elucidates gut-kidney connection.
Katagiri D, Hamasaki Y, Doi K, Okamoto K, Negishi K, Nangaku M, Noiri E
(2013) J Am Soc Nephrol 24: 2034-43
MeSH Terms: Acute Kidney Injury, Animals, Antineoplastic Agents, Apoptosis, Cisplatin, Dipeptidyl-Peptidase IV Inhibitors, Exenatide, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Hypoglycemic Agents, Intestinal Mucosa, Male, Mice, Mice, Inbred C57BL, Oxidative Stress, Peptides, Piperidines, RNA, Small Interfering, Receptors, Glucagon, Reperfusion Injury, Uracil, Venoms
Added February 11, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms