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Synergistic Transcriptional Changes in AMPA and GABA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss.
Balaram P, Hackett TA, Polley DB
(2019) Neuroscience 407: 108-119
MeSH Terms: Animals, Auditory Cortex, Auditory Pathways, Hearing Loss, Unilateral, Hyperacusis, Inferior Colliculi, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity, Neurons, Receptors, AMPA, Receptors, GABA-A, Synaptic Transmission
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.
Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA
(2017) Sci Rep 7: 15327
MeSH Terms: Animals, Anticonvulsants, Epilepsies, Myoclonic, GABA-A Receptor Agonists, Hydroxycholesterols, Mice, Mice, Mutant Strains, NAV1.1 Voltage-Gated Sodium Channel, Receptors, GABA-A
Added October 2, 2018
1 Communities
0 Members
0 Resources
9 MeSH Terms
Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2 Dravet syndrome mice.
Huang X, Zhou C, Tian M, Kang JQ, Shen W, Verdier K, Pimenta A, MacDonald RL
(2017) Epilepsia 58: 1451-1461
MeSH Terms: Action Potentials, Animals, Convulsants, Electric Stimulation, Epilepsies, Myoclonic, Humans, In Vitro Techniques, Inhibitory Postsynaptic Potentials, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neural Pathways, Patch-Clamp Techniques, Pentylenetetrazole, Protein Subunits, Pyramidal Cells, Receptors, GABA-A, Somatosensory Cortex, Thalamus
Added June 21, 2017
1 Communities
0 Members
0 Resources
21 MeSH Terms
Altered Channel Conductance States and Gating of GABA Receptors by a Pore Mutation Linked to Dravet Syndrome.
Hernandez CC, Kong W, Hu N, Zhang Y, Shen W, Jackson L, Liu X, Jiang Y, Macdonald RL
(2017) eNeuro 4:
MeSH Terms: Animals, Cell Membrane, Cerebral Cortex, Epilepsies, Myoclonic, HEK293 Cells, Humans, Inhibitory Postsynaptic Potentials, Mice, Inbred C57BL, Miniature Postsynaptic Potentials, Models, Molecular, Mutation, Missense, Neurons, Receptors, GABA-A, Recombinant Proteins, Zinc
Added April 6, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
Hawkins NA, Zachwieja NJ, Miller AR, Anderson LL, Kearney JA
(2016) PLoS Genet 12: e1006398
MeSH Terms: Animals, Benzodiazepines, Chromosome Mapping, Chromosomes, Clobazam, Disease Models, Animal, Epilepsies, Myoclonic, Epilepsy, Gene Expression Regulation, Genes, Modifier, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Humans, Mice, Mice, Knockout, Mutation, NAV1.1 Voltage-Gated Sodium Channel, Phenotype, Receptors, GABA-A, Seizures
Added October 2, 2018
1 Communities
0 Members
0 Resources
20 MeSH Terms
Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man.
Hedrington MS, Tate DB, Younk LM, Davis SN
(2015) Diabetes 64: 3253-61
MeSH Terms: Adult, Alprazolam, Autonomic Nervous System, Bicycling, Blood Glucose, Epinephrine, Exercise, Female, GABA-A Receptor Agonists, Glucagon, Glucose Clamp Technique, Human Growth Hormone, Humans, Hydrocortisone, Lipolysis, Male, Norepinephrine, Pituitary-Adrenal System, Receptors, GABA-A
Added July 30, 2015
0 Communities
0 Members
2 Resources
19 MeSH Terms
Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome.
Zhou C, Ding L, Deel ME, Ferrick EA, Emeson RB, Gallagher MJ
(2015) Neurobiol Dis 73: 407-17
MeSH Terms: Animals, Blotting, Western, Disease Models, Animal, Epilepsy, Absence, Inhibitory Postsynaptic Potentials, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Confocal, RNA Editing, Receptors, GABA-A, Synaptic Transmission, Thalamic Nuclei
Added January 20, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).
Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL
(2014) Neurobiol Dis 69: 215-24
MeSH Terms: Cell Membrane, Conserved Sequence, Cycloheximide, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Glycosylation, HEK293 Cells, Humans, Models, Molecular, Mutation, Missense, Patch-Clamp Techniques, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Synthesis Inhibitors, Protein Transport, Receptors, GABA-A, Seizures, Febrile, gamma-Aminobutyric Acid
Added January 24, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma.
Tang D, Nickels ML, Tantawy MN, Buck JR, Manning HC
(2014) Mol Imaging Biol 16: 813-20
MeSH Terms: Animals, Brain Neoplasms, Carrier Proteins, Fluorine Radioisotopes, Glioma, Ligands, Mice, Mice, Inbred C57BL, Positron-Emission Tomography, Pyrazoles, Pyrimidines, Rats, Rats, Wistar, Receptors, GABA, Receptors, GABA-A
Added January 23, 2015
0 Communities
2 Members
0 Resources
15 MeSH Terms
Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents.
Huang X, Hernandez CC, Hu N, Macdonald RL
(2014) Neurobiol Dis 68: 167-79
MeSH Terms: Adenosine Triphosphatases, Animals, Cells, Cultured, Cerebral Cortex, Computer Simulation, Embryo, Mammalian, Gene Expression Regulation, HEK293 Cells, Humans, Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase, Membrane Potentials, Models, Molecular, Mutation, Missense, Protein Subunits, Protein Transport, Rats, Receptors, GABA-A, Temperature
Added January 24, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms