Synergistic Transcriptional Changes in AMPA and GABA Receptor Genes Support Compensatory Plasticity Following Unilateral Hearing Loss.Balaram P, Hackett TA, Polley DB
(2019)
Neuroscience 407: 108-119
MeSH Terms: Animals, Auditory Cortex, Auditory Pathways, Hearing Loss, Unilateral, Hyperacusis, Inferior Colliculi, Mice, Inbred C57BL, Mice, Transgenic, Neuronal Plasticity, Neurons, Receptors, AMPA, Receptors, GABA-A, Synaptic TransmissionAdded March 3, 2020 0 Communities
1 Members
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MeSH Terms
The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA
(2017)
Sci Rep 7: 15327
MeSH Terms: Animals, Anticonvulsants, Epilepsies, Myoclonic, GABA-A Receptor Agonists, Hydroxycholesterols, Mice, Mice, Mutant Strains, NAV1.1 Voltage-Gated Sodium Channel, Receptors, GABA-AAdded October 2, 2018 1 Communities
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9 MeSH Terms
Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2 Dravet syndrome mice.Huang X, Zhou C, Tian M, Kang JQ, Shen W, Verdier K, Pimenta A, MacDonald RL
(2017)
Epilepsia 58: 1451-1461
MeSH Terms: Action Potentials, Animals, Convulsants, Electric Stimulation, Epilepsies, Myoclonic, Humans, In Vitro Techniques, Inhibitory Postsynaptic Potentials, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neural Pathways, Patch-Clamp Techniques, Pentylenetetrazole, Protein Subunits, Pyramidal Cells, Receptors, GABA-A, Somatosensory Cortex, ThalamusAdded June 21, 2017 1 Communities
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21 MeSH Terms
Altered Channel Conductance States and Gating of GABA Receptors by a Pore Mutation Linked to Dravet Syndrome.Hernandez CC, Kong W, Hu N, Zhang Y, Shen W, Jackson L, Liu X, Jiang Y, Macdonald RL
(2017)
eNeuro 4:
MeSH Terms: Animals, Cell Membrane, Cerebral Cortex, Epilepsies, Myoclonic, HEK293 Cells, Humans, Inhibitory Postsynaptic Potentials, Mice, Inbred C57BL, Miniature Postsynaptic Potentials, Models, Molecular, Mutation, Missense, Neurons, Receptors, GABA-A, Recombinant Proteins, ZincAdded April 6, 2017 0 Communities
1 Members
0 Resources
15 MeSH Terms
Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.Hawkins NA, Zachwieja NJ, Miller AR, Anderson LL, Kearney JA
(2016)
PLoS Genet 12: e1006398
MeSH Terms: Animals, Benzodiazepines, Chromosome Mapping, Chromosomes, Clobazam, Disease Models, Animal, Epilepsies, Myoclonic, Epilepsy, Gene Expression Regulation, Genes, Modifier, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Humans, Mice, Mice, Knockout, Mutation, NAV1.1 Voltage-Gated Sodium Channel, Phenotype, Receptors, GABA-A, SeizuresAdded October 2, 2018 1 Communities
0 Members
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20 MeSH Terms
Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man.Hedrington MS, Tate DB, Younk LM, Davis SN
(2015)
Diabetes 64: 3253-61
MeSH Terms: Adult, Alprazolam, Autonomic Nervous System, Bicycling, Blood Glucose, Epinephrine, Exercise, Female, GABA-A Receptor Agonists, Glucagon, Glucose Clamp Technique, Human Growth Hormone, Humans, Hydrocortisone, Lipolysis, Male, Norepinephrine, Pituitary-Adrenal System, Receptors, GABA-AAdded July 30, 2015 0 Communities
0 Members
2 Resources
19 MeSH Terms
Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome.Zhou C, Ding L, Deel ME, Ferrick EA, Emeson RB, Gallagher MJ
(2015)
Neurobiol Dis 73: 407-17
MeSH Terms: Animals, Blotting, Western, Disease Models, Animal, Epilepsy, Absence, Inhibitory Postsynaptic Potentials, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Confocal, RNA Editing, Receptors, GABA-A, Synaptic Transmission, Thalamic NucleiAdded January 20, 2015 0 Communities
1 Members
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13 MeSH Terms
GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL
(2014)
Neurobiol Dis 69: 215-24
MeSH Terms: Cell Membrane, Conserved Sequence, Cycloheximide, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Glycosylation, HEK293 Cells, Humans, Models, Molecular, Mutation, Missense, Patch-Clamp Techniques, Protein Structure, Secondary, Protein Structure, Tertiary, Protein Synthesis Inhibitors, Protein Transport, Receptors, GABA-A, Seizures, Febrile, gamma-Aminobutyric AcidAdded January 24, 2015 0 Communities
1 Members
0 Resources
18 MeSH Terms
Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma.Tang D, Nickels ML, Tantawy MN, Buck JR, Manning HC
(2014)
Mol Imaging Biol 16: 813-20
MeSH Terms: Animals, Brain Neoplasms, Carrier Proteins, Fluorine Radioisotopes, Glioma, Ligands, Mice, Mice, Inbred C57BL, Positron-Emission Tomography, Pyrazoles, Pyrimidines, Rats, Rats, Wistar, Receptors, GABA, Receptors, GABA-AAdded January 23, 2015 0 Communities
2 Members
0 Resources
15 MeSH Terms
Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents.Huang X, Hernandez CC, Hu N, Macdonald RL
(2014)
Neurobiol Dis 68: 167-79
MeSH Terms: Adenosine Triphosphatases, Animals, Cells, Cultured, Cerebral Cortex, Computer Simulation, Embryo, Mammalian, Gene Expression Regulation, HEK293 Cells, Humans, Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase, Membrane Potentials, Models, Molecular, Mutation, Missense, Protein Subunits, Protein Transport, Rats, Receptors, GABA-A, TemperatureAdded January 24, 2015 0 Communities
1 Members
0 Resources
18 MeSH Terms