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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 22

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Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.
Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE
(2017) Mol Pharmacol 91: 39-47
MeSH Terms: Blood Platelets, Humans, Integrin beta3, Ligands, Platelet Glycoprotein GPIb-IX Complex, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair.
Sato N, Ichikawa J, Wako M, Ohba T, Saito M, Sato H, Koyama K, Hagino T, Schoenecker JG, Ando T, Haro H
(2016) Bone 83: 23-34
MeSH Terms: Animals, Cell Movement, Chemokine CCL2, Disease Models, Animal, Fracture Healing, Humans, Inflammation, Interleukin-6, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Models, Biological, Osteoblasts, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RAW 264.7 Cells, Receptor, PAR-1, Thrombin, Thromboplastin
Added February 22, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention.
Friedman EA, Texeira L, Delaney J, Weeke PE, Lynch DR, Kasasbeh E, Song Y, Harrell FE, Denny JC, Hamm HE, Roden DM, Cleator JH
(2016) J Thromb Thrombolysis 41: 656-62
MeSH Terms: Aged, Aged, 80 and over, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Myocardial Infarction, Percutaneous Coronary Intervention, Polymorphism, Genetic, Postoperative Hemorrhage, Receptor, PAR-1, Stroke
Added March 14, 2018
0 Communities
3 Members
0 Resources
13 MeSH Terms
Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation.
Duvernay MT, Matafonov A, Lindsley CW, Hamm HE
(2015) Biochemistry 54: 5578-88
MeSH Terms: Benzoates, Blood Platelets, Glycerophospholipids, Group IV Phospholipases A2, Humans, Lipids, Oligopeptides, Peptide Fragments, Platelet Activation, Platelet Membrane Glycoproteins, Receptor, PAR-1, Receptors, Thrombin, Spectrometry, Mass, Electrospray Ionization, Stress, Mechanical, Sulfonamides, Thrombin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation.
Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB
(2013) J Lipid Res 54: 3085-97
MeSH Terms: Aspirin, Blood Platelets, Calcium, Cyclooxygenase 1, Cyclooxygenase Inhibitors, Dinoprostone, Dose-Response Relationship, Drug, Esterification, Feedback, Physiological, Humans, Intracellular Space, MAP Kinase Kinase 1, Phosphatidylethanolamines, Phospholipids, Platelet Activation, Prostaglandin D2, Prostaglandins, Protein Kinase C, Receptor, PAR-1, Thrombin, src-Family Kinases
Added March 7, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.
Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE, Hamm H
(2013) Mol Pharmacol 83: 781-92
MeSH Terms: Blood Platelets, Factor V, Gene Expression Regulation, Humans, Receptor, PAR-1, Receptors, Thrombin, Thrombin
Added December 10, 2013
1 Communities
3 Members
0 Resources
7 MeSH Terms
Mathematical model of PAR1-mediated activation of human platelets.
Lenoci L, Duvernay M, Satchell S, DiBenedetto E, Hamm HE
(2011) Mol Biosyst 7: 1129-37
MeSH Terms: Blood Platelets, Calcium, Cytosol, Exocytosis, Humans, Integrins, Models, Theoretical, Platelet Activation, Receptor, PAR-1, Signal Transduction, Thrombin
Added December 10, 2013
0 Communities
1 Members
0 Resources
11 MeSH Terms
Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.
Rana T, Misra S, Mittal MK, Farrow AL, Wilson KT, Linton MF, Fazio S, Willis IM, Chaudhuri G
(2011) J Biol Chem 286: 6614-26
MeSH Terms: Animals, Calcium, Calpain, Cell Line, Tumor, Down-Regulation, Humans, Leishmania major, Leishmaniasis, Cutaneous, Macrophages, Metalloendopeptidases, Mice, RNA Polymerase III, RNA, Untranslated, Receptor, PAR-1, Transcription Factors, TFIII
Added December 10, 2013
0 Communities
3 Members
0 Resources
15 MeSH Terms
Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen.
Marjoram RJ, Voss B, Pan Y, Dickeson SK, Zutter MM, Hamm HE, Santoro SA
(2009) J Biol Chem 284: 34640-7
MeSH Terms: Amino Acid Motifs, Animals, Blood Platelets, Carrier Proteins, Collagen, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Integrin alpha2beta1, Mice, Mice, Inbred C57BL, Peptides, Platelet Adhesiveness, Platelet Aggregation, Platelet Membrane Glycoproteins, Rats, Receptor, PAR-1, Receptors, Collagen, Receptors, G-Protein-Coupled, Receptors, IgG, Receptors, Thrombin, Signal Transduction, Thrombin, Type C Phospholipases
Added December 10, 2013
1 Communities
2 Members
0 Resources
23 MeSH Terms
Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.
Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE
(2009) Mol Pharmacol 76: 301-13
MeSH Terms: Blood Platelets, Humans, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates, Platelet Activation, Platelet Aggregation, Receptor, PAR-1, Signal Transduction, rap1 GTP-Binding Proteins
Added December 10, 2013
0 Communities
2 Members
0 Resources
9 MeSH Terms