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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 27

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Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.
Kamp F, Scheidt HA, Winkler E, Basset G, Heinel H, Hutchison JM, LaPointe LM, Sanders CR, Steiner H, Huster D
(2018) ACS Chem Neurosci 9: 1702-1713
MeSH Terms: Amyloid Precursor Protein Secretases, Amyloid beta-Protein Precursor, Bexarotene, Cholesterol, HEK293 Cells, Humans, Liposomes, Molecular Structure, Neuroprotective Agents, Phosphatidylcholines, Protein Conformation, alpha-Helical, Protein Domains, Receptor, Notch1, Static Electricity
Added November 21, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
Dodecyl-β-melibioside Detergent Micelles as a Medium for Membrane Proteins.
Hutchison JM, Lu Z, Li GC, Travis B, Mittal R, Deatherage CL, Sanders CR
(2017) Biochemistry 56: 5481-5484
MeSH Terms: Amyloid beta-Protein Precursor, Detergents, Diacylglycerol Kinase, Disaccharides, Dynamic Light Scattering, Enzyme Stability, Escherichia coli Proteins, Glucosides, Glycolipids, Hot Temperature, Humans, Micelles, Myelin Proteins, Nuclear Magnetic Resonance, Biomolecular, Particle Size, Peptide Fragments, Protein Interaction Domains and Motifs, Protein Stability, Receptor, Notch1
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.
Broadus MR, Chen TW, Neitzel LR, Ng VH, Jodoin JN, Lee LA, Salic A, Robbins DJ, Capobianco AJ, Patton JG, Huppert SS, Lee E
(2016) Cell Rep 15: 1920-9
MeSH Terms: Amino Acid Sequence, Animals, Cell Extracts, Embryo, Nonmammalian, F-Box Proteins, HEK293 Cells, Humans, Muscle Proteins, Mutation, Protein Binding, Protein Domains, Protein Stability, Proteolysis, Receptor, Notch1, Regulatory Sequences, Nucleic Acid, Sequence Homology, Amino Acid, Transcription, Genetic, Ubiquitin-Protein Ligases, Xenopus, Zebrafish
Added February 13, 2017
0 Communities
2 Members
0 Resources
20 MeSH Terms
Notch Transmembrane Domain: Secondary Structure and Topology.
Deatherage CL, Lu Z, Kim JH, Sanders CR
(2015) Biochemistry 54: 3565-8
MeSH Terms: Humans, Lipid Bilayers, Lysophosphatidylcholines, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Peptide Fragments, Phosphatidylcholines, Protein Conformation, Protein Structure, Secondary, Protein Structure, Tertiary, Receptor, Notch1, Recombinant Proteins, Surface Properties
Added February 5, 2016
1 Communities
1 Members
0 Resources
13 MeSH Terms
Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.
Li J, Kurasawa Y, Wang Y, Clise-Dwyer K, Klumpp SA, Liang H, Tailor RC, Raymond AC, Estrov Z, Brandt SJ, Davis RE, Zweidler-McKay P, Amin HM, Nagarajan L
(2014) J Immunol 193: 4654-62
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Bone Marrow, Bone Marrow Transplantation, Cell Differentiation, DNA-Binding Proteins, Gene Expression, Hematopoiesis, Hematopoietic Stem Cells, Homeostasis, Immunophenotyping, Mice, Mice, Knockout, Phenotype, Receptor, Notch1, Stress, Physiological
Added February 14, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.
Volanakis EJ, Boothby MR, Sherr CJ
(2013) Exp Hematol 41: 377-86
MeSH Terms: Animals, Binding Sites, Bone Marrow Cells, Cell Line, Cell Transformation, Neoplastic, Cells, Cultured, Coculture Techniques, Cyclin-Dependent Kinase Inhibitor p16, Disease Progression, Dogs, Epigenesis, Genetic, Flow Cytometry, Gene Expression, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Mutation, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Receptor, Notch1, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, T-Lymphocytes, Thymocytes, Tumor Suppressor Protein p14ARF
Added December 10, 2013
0 Communities
2 Members
0 Resources
25 MeSH Terms
A novel technique for quantifying mouse heart valve leaflet stiffness with atomic force microscopy.
Sewell-Loftin MK, Brown CB, Baldwin HS, Merryman WD
(2012) J Heart Valve Dis 21: 513-20
MeSH Terms: Animals, Aortic Valve, Aortic Valve Insufficiency, Apolipoproteins E, Biomechanical Phenomena, Heterozygote, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Atomic Force, Models, Cardiovascular, Receptor, Notch1, Stress, Mechanical, Swine
Added February 12, 2015
0 Communities
2 Members
0 Resources
14 MeSH Terms
Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients.
Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S
(2012) Hum Mol Genet 21: 1374-83
MeSH Terms: Alagille Syndrome, Animals, Blotting, Western, Calcium-Binding Proteins, Cells, Cultured, Craniofacial Abnormalities, Embryo, Mammalian, Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Integrases, Intercellular Signaling Peptides and Proteins, Jagged-1 Protein, Membrane Proteins, Mesoderm, Mice, Mice, Inbred C57BL, Mice, Knockout, Morphogenesis, Neural Crest, Phenotype, RNA, Messenger, Real-Time Polymerase Chain Reaction, Receptor, Notch1, Reverse Transcriptase Polymerase Chain Reaction, Serrate-Jagged Proteins, Wnt1 Protein
Added December 16, 2011
1 Communities
2 Members
0 Resources
28 MeSH Terms
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ
(2011) Proc Natl Acad Sci U S A 108: 17761-6
MeSH Terms: Base Sequence, Carcinoma, Squamous Cell, Cell Communication, Codon, Nonsense, Electrophoretic Mobility Shift Assay, Humans, Lod Score, Lung Neoplasms, Molecular Sequence Data, Receptor, Notch1, Receptor, Notch2, Sequence Analysis, DNA, Signal Transduction, Skin Neoplasms
Added March 10, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.
Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP
(2011) Blood 117: 5453-62
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Cell Transformation, Neoplastic, Cocarcinogenesis, Cyclin-Dependent Kinase Inhibitor p16, DNA-Binding Proteins, Disease Progression, Female, Gene Expression, LIM Domain Proteins, Loss of Heterozygosity, Male, Metalloproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Mutation, Neoplastic Stem Cells, Precursor Cells, T-Lymphoid, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Promoter Regions, Genetic, Receptor, Notch1, Signal Transduction
Added May 27, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms