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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 30

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Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.
Anderson EJP, Ghamari-Langroudi M, Cakir I, Litt MJ, Chen V, Reggiardo RE, Millhauser GL, Cone RD
(2019) J Neuroendocrinol 31: e12670
MeSH Terms: Animals, Feeding Behavior, Female, Hypothalamus, Male, Membrane Potentials, Mice, Inbred C57BL, Mice, Knockout, Neurons, Obesity, Potassium Channels, Inwardly Rectifying, Receptor, Melanocortin, Type 4
Added January 8, 2019
1 Communities
0 Members
0 Resources
12 MeSH Terms
Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.
Litt MJ, Okoye GD, Lark D, Cakir I, Moore C, Barber MC, Atkinson J, Fessel J, Moslehi J, Cone RD
(2017) Elife 6:
MeSH Terms: Adenosine Diphosphate, Animals, Cardiomyopathy, Dilated, Cell Respiration, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Myocardium, Myocytes, Cardiac, Reactive Oxygen Species, Receptor, Melanocortin, Type 4
Added December 2, 2017
0 Communities
2 Members
0 Resources
11 MeSH Terms
Functional variants of the melanocortin-4 receptor associated with the Odontoceti and Mysticeti suborders of cetaceans.
Zhao L, Zhou X, Rokas A, Cone RD
(2017) Sci Rep 7: 5684
MeSH Terms: Amino Acid Sequence, Animals, Body Size, Cetacea, Evolution, Molecular, Feeding Behavior, Phylogeny, Receptor, Melanocortin, Type 4, alpha-MSH
Added March 21, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.
Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC
(2015) J Clin Endocrinol Metab 100: 1639-45
MeSH Terms: Adult, Anti-Obesity Agents, Combined Modality Therapy, Cross-Over Studies, Double-Blind Method, Energy Metabolism, Female, Humans, Male, Middle Aged, Obesity, Receptor, Melanocortin, Type 4, Rest, Weight Reduction Programs, Young Adult, alpha-MSH
Added February 4, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
(2015) Nature 520: 94-8
MeSH Terms: Action Potentials, Agouti-Related Protein, Animals, Eating, Energy Metabolism, Female, GTP-Binding Protein alpha Subunits, Gs, HEK293 Cells, Homeostasis, Humans, Ligands, Male, Melanocortins, Mice, Neurons, Paraventricular Hypothalamic Nucleus, Potassium Channels, Inwardly Rectifying, Receptor, Melanocortin, Type 4, Signal Transduction, alpha-MSH
Added February 4, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD
(2014) Cell Metab 20: 1018-29
MeSH Terms: Acids, Heterocyclic, Animals, Colon, Enteroendocrine Cells, Glucagon-Like Peptide 1, Humans, Immunohistochemistry, Mice, Mice, Inbred C57BL, Mice, Transgenic, Oxadiazoles, Peptide YY, Peptides, Cyclic, Receptor, Melanocortin, Type 4
Added January 20, 2015
0 Communities
2 Members
0 Resources
14 MeSH Terms
A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.
Huang H, Tao YX
(2014) Int J Biol Sci 10: 817-24
MeSH Terms: Flow Cytometry, HEK293 Cells, Humans, Microscopy, Confocal, Receptor, Melanocortin, Type 4, Tetrahydroisoquinolines, Triazoles
Added January 29, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.
Lippert RN, Ellacott KL, Cone RD
(2014) Endocrinology 155: 1718-27
MeSH Terms: Animals, Appetitive Behavior, Behavior, Animal, Dopamine, Dopaminergic Neurons, Female, Food Preferences, Green Fluorescent Proteins, Homeostasis, Limbic System, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Mutant Strains, Mice, Transgenic, Nerve Tissue Proteins, Ovariectomy, Promoter Regions, Genetic, Receptor, Melanocortin, Type 3, Receptor, Melanocortin, Type 4, Sex Characteristics, Ventral Tegmental Area
Added May 27, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
Hohenadel MG, Thearle MS, Grice BA, Huang H, Dai MH, Tao YX, Hunter LA, Palaguachi GI, Mou Z, Kim RC, Tsang MM, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Muller YL, Baier LJ, Krakoff J, Knowler WC, Yanovski JA, Han JC
(2014) Int J Obes (Lond) 38: 1068-74
MeSH Terms: Adolescent, Adult, Arizona, Brain-Derived Neurotrophic Factor, Child, Child, Preschool, Cohort Studies, Female, Genetic Predisposition to Disease, Genotype, Hispanic Americans, Humans, Hypothalamus, Indians, North American, Longitudinal Studies, Male, Mutation, Obesity, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Receptor, Melanocortin, Type 4
Added January 29, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD
(2013) Science 341: 278-81
MeSH Terms: Animals, Embryo, Nonmammalian, Energy Metabolism, HEK293 Cells, Humans, Receptor Activity-Modifying Proteins, Receptor, Melanocortin, Type 4, Zebrafish, Zebrafish Proteins, alpha-MSH
Added May 27, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms