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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 43

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In vivo evaluation of IGF1R/IR PET ligand [F]BMS-754807 in rodents.
Prabhakaran J, Dewey SL, McClure R, Simpson NR, Tantawy MN, Mann JJ, Pham W, Kumar JSD
(2017) Bioorg Med Chem Lett 27: 941-943
MeSH Terms: Animals, Fluorine Radioisotopes, Heterografts, Humans, Mice, Positron-Emission Tomography, Pyrazoles, Radioligand Assay, Rats, Receptor, IGF Type 1, Receptor, Insulin, Triazines
Added March 21, 2018
0 Communities
2 Members
0 Resources
12 MeSH Terms
BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.
Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J
(2016) Oncotarget 7: 43504-43517
MeSH Terms: Animals, Antineoplastic Agents, Autocrine Communication, Azepines, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Epigenesis, Genetic, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Insulin-Like Growth Factor I, Mice, Mice, Nude, NIH 3T3 Cells, Oncogene Proteins, Fusion, Proteins, Proto-Oncogene Protein c-fli-1, Proto-Oncogene Proteins c-akt, RNA-Binding Protein EWS, Receptor, IGF Type 1, Receptors, Somatomedin, Sarcoma, Ewing, Signal Transduction, Transcription, Genetic, Triazoles, Xenograft Model Antitumor Assays
Added November 19, 2016
0 Communities
3 Members
0 Resources
29 MeSH Terms
Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.
Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso GJ, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AN, Davé UP, Love PE, Ehrlich LI
(2016) Proc Natl Acad Sci U S A 113: E1016-25
MeSH Terms: Animals, Cell Line, Tumor, Cell Survival, Dendritic Cells, Female, Humans, Male, Mice, Neoplasm Proteins, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Receptor, IGF Type 1, Receptor, Platelet-Derived Growth Factor beta, Receptors, Somatomedin, Signal Transduction, Tumor Microenvironment
Added February 22, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.
Ma Y, Tang N, Thompson RC, Mobley BC, Clark SW, Sarkaria JN, Wang J
(2016) Clin Cancer Res 22: 1767-76
MeSH Terms: Animals, Antineoplastic Agents, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm, ErbB Receptors, Gefitinib, Glioblastoma, Humans, Insulin, Insulin-Like Growth Factor I, Mice, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Quinazolines, Receptor, IGF Type 1, Receptor, Insulin, Signal Transduction, Tumor Burden, Xenograft Model Antitumor Assays
Added April 18, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade.
Iams WT, Lovly CM
(2015) Clin Cancer Res 21: 4270-7
MeSH Terms: Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Clinical Trials as Topic, Drug Resistance, Neoplasm, Female, Humans, Male, Molecular Targeted Therapy, Neoplasms, Protein Kinase Inhibitors, Receptor, IGF Type 1, Signal Transduction, Translational Medical Research, Treatment Outcome
Added January 26, 2016
0 Communities
1 Members
0 Resources
14 MeSH Terms
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.
Gong Y, Ma Y, Sinyuk M, Loganathan S, Thompson RC, Sarkaria JN, Chen W, Lathia JD, Mobley BC, Clark SW, Wang J
(2016) Neuro Oncol 18: 48-57
MeSH Terms: Animals, Antigens, CD, Brain Neoplasms, Cell Proliferation, Cell Survival, Female, Glioblastoma, Humans, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Mice, Nude, Proto-Oncogene Proteins c-akt, Receptor, IGF Type 1, Receptor, Insulin, Receptors, Somatomedin, Signal Transduction, Tumor Cells, Cultured
Added July 23, 2015
1 Communities
3 Members
0 Resources
18 MeSH Terms
Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis.
Liang M, Woodard LE, Liang A, Luo J, Wilson MH, Mitch WE, Cheng J
(2015) Am J Pathol 185: 1234-50
MeSH Terms: Animals, Blotting, Western, Cells, Cultured, Disease Models, Animal, Endothelial Cells, Fibrosis, Humans, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Transmission, Polymerase Chain Reaction, Receptor, IGF Type 1, Renal Insufficiency, Chronic, Transfection, Umbilical Veins, Ureteral Obstruction
Added April 8, 2015
0 Communities
2 Members
0 Resources
19 MeSH Terms
Skeletal muscle insulin resistance in zebrafish induces alterations in β-cell number and glucose tolerance in an age- and diet-dependent manner.
Maddison LA, Joest KE, Kammeyer RM, Chen W
(2015) Am J Physiol Endocrinol Metab 308: E662-9
MeSH Terms: Aging, Animals, Animals, Genetically Modified, Biological Transport, Cell Count, Disease Progression, Glucose, Glucose Intolerance, Green Fluorescent Proteins, Hyperglycemia, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Insulin-Secreting Cells, Luminescent Proteins, Muscle, Skeletal, Overnutrition, Receptor, IGF Type 1, Recombinant Fusion Proteins, Zebrafish, Zebrafish Proteins
Added February 12, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q, Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RT, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, Oh JH, Liu J, Umemura S, Kim YJ, Jiang F, Maeda S, Chan JC, Lu W, Hixson JE, Adair LS, Jung KJ, Nabika T, Bae JB, Lee MH, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee SH, Shin MH, Shin DH, Choi BY, Shi J, Gao YT, Xiang YB, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RC, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han BG, Cho YS, Kim BJ
(2015) Diabetes 64: 291-8
MeSH Terms: Adaptor Proteins, Signal Transducing, Adult, Aged, Asian Continental Ancestry Group, Blood Glucose, Cytoskeletal Proteins, Far East, Fasting, Female, Genetic Variation, Genome-Wide Association Study, Genotype, Guanine Nucleotide Exchange Factors, Humans, Male, Middle Aged, Phenotype, Protein-Serine-Threonine Kinases, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Receptor, IGF Type 1, Tumor Suppressor Proteins
Added February 22, 2016
0 Communities
2 Members
0 Resources
21 MeSH Terms
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W
(2014) Nat Med 20: 1027-34
MeSH Terms: Anaplastic Lymphoma Kinase, Crizotinib, Female, Gene Knockdown Techniques, Humans, Insulin Receptor Substrate Proteins, Lung Neoplasms, Middle Aged, Pyrazoles, Pyridines, Receptor Protein-Tyrosine Kinases, Receptor, IGF Type 1, Up-Regulation
Added February 13, 2015
0 Communities
2 Members
0 Resources
13 MeSH Terms