The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.
Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J
(2016) Cancer Res 76
: 1825-36MeSH Terms: Animals, Breast Neoplasms, Cell Proliferation, Ephrin-A1, Female, Glutamine, Humans, Mice, Receptor, EphA2, Signal TransductionAdded February 7, 2019
EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer.
Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J
(2016) Cancer Res 76
: 305-18MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Benzamides, Cell Line, Tumor, Cell Proliferation, Drug Resistance, Neoplasm, Drug Synergism, ErbB Receptors, Erlotinib Hydrochloride, Humans, Lung Neoplasms, Mice, Mice, Nude, Niacinamide, Protein Kinase Inhibitors, Receptor, EphA2, Signal Transduction, Xenograft Model Antitumor AssaysAdded January 26, 2016
19 MeSH Terms
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.
Koshikawa N, Hoshino D, Taniguchi H, Minegishi T, Tomari T, Nam SO, Aoki M, Sueta T, Nakagawa T, Miyamoto S, Nabeshima K, Weaver AM, Seiki M
(2015) Cancer Res 75
: 3327-39MeSH Terms: Animals, Binding Sites, Blotting, Western, Cell Line, Tumor, Humans, Male, Matrix Metalloproteinase 14, Mice, Inbred BALB C, Microscopy, Fluorescence, Mutation, Neoplasm Metastasis, Neoplasms, Oncogene Proteins, Phosphorylation, Proteolysis, RNA Interference, Receptor, EphA2, Transplantation, Heterologous, Tumor Burden, Tumor Suppressor ProteinsAdded February 15, 2016
20 MeSH Terms
Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC.
Amato KR, Wang S, Hastings AK, Youngblood VM, Santapuram PR, Chen H, Cates JM, Colvin DC, Ye F, Brantley-Sieders DM, Cook RS, Tan L, Gray NS, Chen J
(2014) J Clin Invest 124
: 2037-49MeSH Terms: Animals, Apoptosis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Heterografts, Humans, Lung Neoplasms, Mice, Mice, Knockout, Neoplasm Proteins, Neoplasm Transplantation, Protein Kinase Inhibitors, Receptor, EphA2, Ribosomal Protein S6 Kinases, 70-kDa, Ribosomal Protein S6 Kinases, 90-kDaAdded December 8, 2014
16 MeSH Terms
JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
(2014) Cancer Res 74
: 2444-54MeSH Terms: Aldehyde Dehydrogenase, Animals, Anthracenes, Carcinogenesis, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Movement, Cell Proliferation, Gene Knockdown Techniques, Humans, JNK Mitogen-Activated Protein Kinases, Lung Neoplasms, MAP Kinase Signaling System, Mice, Mice, Nude, Neoplasm Transplantation, Neoplastic Stem Cells, Phosphorylation, Protein Processing, Post-Translational, Receptor, EphA2, Tumor BurdenAdded March 27, 2014
21 MeSH Terms
EphA2 signaling following endocytosis: role of Tiam1.
Boissier P, Chen J, Huynh-Do U
(2013) Traffic 14
: 1255-71MeSH Terms: Animals, Cell Line, Tumor, Cell Membrane, Endocytosis, Guanine Nucleotide Exchange Factors, Humans, Lysosomes, Mice, Receptor, EphA2, Signal Transduction, T-Lymphoma Invasion and Metastasis-inducing Protein 1, rac1 GTP-Binding ProteinAdded March 5, 2014
12 MeSH Terms
The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus.
Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M, Chen J, König S, Ensser A, Myoung J, Brockmeyer NH, Stürzl M, Fleckenstein B, Neipel F
(2012) Nat Med 18
: 961-6MeSH Terms: Animals, Cell Line, Endocytosis, Herpesvirus 8, Human, Humans, Mice, Phosphorylation, Receptor, EphA2, Receptors, Virus, Viral Envelope Proteins, Viral ProteinsAdded March 5, 2014
11 MeSH Terms
EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.
Funk SD, Yurdagul A, Albert P, Traylor JG, Jin L, Chen J, Orr AW
(2012) Arterioscler Thromb Vasc Biol 32
: 686-95MeSH Terms: Animals, Apolipoproteins E, Atherosclerosis, Cell Adhesion, Cells, Cultured, Coculture Techniques, Cytokines, Disease Models, Animal, Endothelial Cells, Gene Expression Regulation, Human Umbilical Vein Endothelial Cells, Humans, Inflammation, Inflammation Mediators, Lipoproteins, LDL, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Monocytes, Phenotype, RNA Interference, Receptor, EphA2, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Time Factors, TransfectionAdded March 5, 2014
27 MeSH Terms
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.
Brantley-Sieders DM, Jiang A, Sarma K, Badu-Nkansah A, Walter DL, Shyr Y, Chen J
(2011) PLoS One 6
: e24426MeSH Terms: Breast Neoplasms, Ephrin-A1, Ephrins, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Vitro Techniques, Receptor, EphA2, Receptor, EphA4, Receptor, EphA7, Receptor, EphB4, Receptor, EphB6, Tissue Array AnalysisAdded February 13, 2014
14 MeSH Terms
Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium.
Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J
(2011) Cancer Res 71
: 976-87MeSH Terms: Adenocarcinoma, Animals, Breast Neoplasms, Cell Growth Processes, Cell Movement, Endothelial Cells, Female, Humans, Intercellular Signaling Peptides and Proteins, Mammary Neoplasms, Experimental, Mice, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic, Nerve Tissue Proteins, Prognosis, Receptor, EphA2Added February 13, 2014
17 MeSH Terms