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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 30

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Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
Sekhar KR, Wang J, Freeman ML, Kirschner AN
(2019) PLoS One 14: e0214670
MeSH Terms: Aged, Animals, Benzamides, Cell Line, Tumor, Cell Proliferation, DNA Damage, DNA Repair, Drug Resistance, Neoplasm, Humans, Male, Mice, Mice, Nude, Mice, Transgenic, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Radiation Tolerance, Radiation-Sensitizing Agents, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
2 Members
0 Resources
21 MeSH Terms
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS
(2017) Invest Ophthalmol Vis Sci 58: 3818-3824
MeSH Terms: Animals, Disease Models, Animal, Fluorescein Angiography, Fluoresceins, Fluorescent Dyes, Hypoxia, Image Processing, Computer-Assisted, Macular Edema, Male, Mice, Mice, Inbred C57BL, Nitroimidazoles, Radiation-Sensitizing Agents, Retinal Neovascularization, Retinal Vein, Retinal Vein Occlusion, Tomography, Optical Coherence
Added December 21, 2017
0 Communities
2 Members
0 Resources
17 MeSH Terms
Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy.
Smith CA, Mont S, Traver G, Sekhar KR, Crooks PA, Freeman ML
(2016) Oncotarget 7: 77926-77936
MeSH Terms: Animals, Cell Line, Tumor, Colorectal Neoplasms, Dose Fractionation, Radiation, HT29 Cells, Humans, Mice, Mice, Nude, Molecular Targeted Therapy, NADH, NADPH Oxidoreductases, Radiation-Sensitizing Agents, Xenograft Model Antitumor Assays
Added March 17, 2017
0 Communities
2 Members
0 Resources
12 MeSH Terms
Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML
(2014) Int J Radiat Oncol Biol Phys 89: 1106-1114
MeSH Terms: Animals, Barbiturates, Carcinoma, Non-Small-Cell Lung, DNA Breaks, Double-Stranded, DNA Repair, Fibroblasts, Histones, Humans, Indoles, Lung Neoplasms, Mice, Mice, Inbred C57BL, Mice, Nude, Molecular Targeted Therapy, Neoplasm Proteins, Nuclear Proteins, Nucleophosmin, Rad51 Recombinase, Radiation Tolerance, Radiation-Sensitizing Agents, Tissue Array Analysis, Tumor Cells, Cultured
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer.
Chen RC, Rosenman JG, Hoffman LG, Chiu WK, Wang AZ, Pruthi RS, Wallen EM, Crane JM, Kim WY, Rathmell WK, Godley PA, Whang YE
(2012) BJU Int 110: E721-6
MeSH Terms: Aged, Androgen Antagonists, Antineoplastic Agents, Disease-Free Survival, Docetaxel, Dose-Response Relationship, Drug, Follow-Up Studies, Gonadotropin-Releasing Hormone, Humans, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms, Radiation-Sensitizing Agents, Radiotherapy Dosage, Radiotherapy, Intensity-Modulated, Taxoids, Treatment Outcome
Added October 17, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Novel radiosensitizing anticancer therapeutics.
Linkous AG, Yazlovitskaya EM
(2012) Anticancer Res 32: 2487-99
MeSH Terms: Animals, Humans, Neoplasms, Neoplastic Stem Cells, Radiation-Sensitizing Agents
Added August 21, 2013
1 Communities
1 Members
0 Resources
5 MeSH Terms
Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cells.
Sun Y, Zheng S, Torossian A, Speirs CK, Schleicher S, Giacalone NJ, Carbone DP, Zhao Z, Lu B
(2012) Int J Radiat Oncol Biol Phys 82: e563-72
MeSH Terms: AC133 Antigen, Aldehyde Dehydrogenase, Animals, Antigens, CD, Apoptosis, Biomarkers, Tumor, Blotting, Western, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Chemoradiotherapy, Cisplatin, Drug Resistance, Neoplasm, Female, Glycoproteins, Humans, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Lung Neoplasms, Mice, Mice, Nude, Microarray Analysis, Peptides, RNA, Small Interfering, Radiation Tolerance, Radiation-Sensitizing Agents, Receptor, IGF Type 1, Recombinant Proteins, Signal Transduction, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization.
Sekhar KR, Reddy YT, Reddy PN, Crooks PA, Venkateswaran A, McDonald WH, Geng L, Sasi S, Van Der Waal RP, Roti JL, Salleng KJ, Rachakonda G, Freeman ML
(2011) Clin Cancer Res 17: 6490-9
MeSH Terms: Animals, Barbiturates, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, DNA Repair, Humans, Indoles, Mice, Mice, Nude, Molecular Chaperones, Molecular Targeted Therapy, Neoplasms, Nuclear Proteins, Nucleophosmin, Radiation Tolerance, Radiation-Sensitizing Agents, Random Allocation
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.
Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE
(2011) PLoS One 6: e22182
MeSH Terms: Animals, Cell Death, Cell Line, Tumor, Cell Movement, Cell Survival, Endothelial Cells, Glioma, Human Umbilical Vein Endothelial Cells, Humans, Lysophospholipids, Mice, Molecular Targeted Therapy, Neovascularization, Pathologic, Phosphoric Diester Hydrolases, Radiation-Sensitizing Agents, Receptors, Lysophosphatidic Acid, Signal Transduction
Added August 21, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer.
Schulte RR, Linkous AG, Hallahan DE, Yazlovitskaya EM
(2011) Cancer Lett 304: 137-43
MeSH Terms: Adenocarcinoma, Animals, Antineoplastic Agents, Arachidonic Acids, Blotting, Western, Combined Modality Therapy, Cytoplasm, Enzyme Activation, Enzyme Inhibitors, Female, Humans, Mice, Mice, Nude, Ovarian Neoplasms, Phospholipases A2, Cytosolic, Radiation-Sensitizing Agents, Signal Transduction, Xenograft Model Antitumor Assays
Added August 21, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms