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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 36

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Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway.
Sekhar KR, Wang J, Freeman ML, Kirschner AN
(2019) PLoS One 14: e0214670
MeSH Terms: Aged, Animals, Benzamides, Cell Line, Tumor, Cell Proliferation, DNA Damage, DNA Repair, Drug Resistance, Neoplasm, Humans, Male, Mice, Mice, Nude, Mice, Transgenic, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant, Radiation Tolerance, Radiation-Sensitizing Agents, Signal Transduction, Xenograft Model Antitumor Assays
Added April 2, 2019
0 Communities
2 Members
0 Resources
21 MeSH Terms
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.
Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E
(2017) Cell Death Differ 24: 731-746
MeSH Terms: Acetylcysteine, Animals, Apoptosis, Cell Proliferation, Cells, Cultured, Cellular Senescence, Epirubicin, Glutamic Acid, Hyperplasia, Keratin-14, Keratinocytes, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Radiation Tolerance, Rapamycin-Insensitive Companion of mTOR Protein, Reactive Oxygen Species, Skin, Tetradecanoylphorbol Acetate, Transcriptome, X-Rays
Added March 7, 2017
2 Communities
1 Members
0 Resources
22 MeSH Terms
Cox-2-derived PGE2 induces Id1-dependent radiation resistance and self-renewal in experimental glioblastoma.
Cook PJ, Thomas R, Kingsley PJ, Shimizu F, Montrose DC, Marnett LJ, Tabar VS, Dannenberg AJ, Benezra R
(2016) Neuro Oncol 18: 1379-89
MeSH Terms: Animals, Blotting, Western, Brain Neoplasms, Chromatin Immunoprecipitation, Cyclooxygenase 2, Dinoprostone, Enzyme-Linked Immunosorbent Assay, Gene Knockdown Techniques, Glioblastoma, Humans, Immunohistochemistry, Inhibitor of Differentiation Protein 1, Mice, Radiation Tolerance, Real-Time Polymerase Chain Reaction, Signal Transduction
Added April 12, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation.
Reddy VK, Short SP, Barrett CW, Mittal MK, Keating CE, Thompson JJ, Harris EI, Revetta F, Bader DM, Brand T, Washington MK, Williams CS
(2016) Stem Cells 34: 1626-36
MeSH Terms: Animals, Cell Adhesion Molecules, Cell Survival, Down-Regulation, Female, Gamma Rays, Gene Deletion, Homeostasis, Intestines, Male, Mice, Inbred C57BL, Muscle Proteins, Radiation Tolerance, Spheroids, Cellular, Stem Cells, Wnt Signaling Pathway
Added February 22, 2016
1 Communities
3 Members
0 Resources
16 MeSH Terms
Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice.
Yazlovitskaya EM, Voziyan PA, Manavalan T, Yarbrough WG, Ivanova AV
(2015) Cell Death Dis 6: e1652
MeSH Terms: Animals, Cytochromes c, DNA Damage, Female, Mice, Mice, Knockout, Oxidative Stress, Radiation Tolerance, STAT3 Transcription Factor, Superoxide Dismutase, Tumor Suppressor Proteins
Added June 9, 2017
1 Communities
2 Members
0 Resources
11 MeSH Terms
Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.
Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS
(2015) Am J Physiol Gastrointest Liver Physiol 308: G562-71
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Cell Survival, DNA Damage, Female, Gamma Rays, Gene Expression Regulation, Goblet Cells, Histones, Intestinal Mucosa, Intestine, Small, Male, Mice, Inbred C57BL, Mice, Knockout, Nuclear Proteins, Phenotype, Radiation Injuries, Experimental, Radiation Tolerance, Regeneration, Repressor Proteins, Signal Transduction, Stem Cells, Tissue Culture Techniques, Transcription Factors, Wnt3A Protein
Added January 20, 2015
1 Communities
5 Members
0 Resources
26 MeSH Terms
Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization.
Sekhar KR, Benamar M, Venkateswaran A, Sasi S, Penthala NR, Crooks PA, Hann SR, Geng L, Balusu R, Abbas T, Freeman ML
(2014) Int J Radiat Oncol Biol Phys 89: 1106-1114
MeSH Terms: Animals, Barbiturates, Carcinoma, Non-Small-Cell Lung, DNA Breaks, Double-Stranded, DNA Repair, Fibroblasts, Histones, Humans, Indoles, Lung Neoplasms, Mice, Mice, Inbred C57BL, Mice, Nude, Molecular Targeted Therapy, Neoplasm Proteins, Nuclear Proteins, Nucleophosmin, Rad51 Recombinase, Radiation Tolerance, Radiation-Sensitizing Agents, Tissue Array Analysis, Tumor Cells, Cultured
Added January 20, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1.
Yazlovitskaya EM, Uzhachenko R, Voziyan PA, Yarbrough WG, Ivanova AV
(2013) Cell Death Dis 4: e687
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Female, Intestinal Mucosa, Intestine, Small, Mice, Mice, Knockout, Mitosis, Radiation Injuries, Experimental, Radiation Tolerance, Signal Transduction, Tumor Suppressor Proteins, Whole-Body Irradiation
Added August 21, 2013
1 Communities
2 Members
0 Resources
14 MeSH Terms
Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL.
Rana T, Schultz MA, Freeman ML, Biswas S
(2012) Free Radic Biol Med 53: 2298-307
MeSH Terms: Animals, Bone Marrow Cells, Cell Survival, Mice, Mice, Knockout, NF-E2-Related Factor 2, Osteoblasts, Osteoclasts, Osteoporosis, Oxidative Stress, RANK Ligand, Radiation Injuries, Experimental, Radiation Tolerance, Skull, Tibia, Up-Regulation
Added March 13, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Gubanova E, Brown B, Ivanov SV, Helleday T, Mills GB, Yarbrough WG, Issaeva N
(2012) Clin Cancer Res 18: 1257-67
MeSH Terms: Adult, Aged, Apoptosis, Ataxia Telangiectasia Mutated Proteins, Carcinoma, Squamous Cell, Cell Cycle Proteins, Cell Line, DNA Methylation, DNA-Binding Proteins, Down-Regulation, Female, Gene Expression Regulation, Neoplastic, Head and Neck Neoplasms, Human papillomavirus 16, Humans, Male, Middle Aged, Oncogene Proteins, Viral, Papillomavirus E7 Proteins, Phosphatidylinositol 3-Kinases, Promoter Regions, Genetic, Protein Serine-Threonine Kinases, Radiation Tolerance, Repressor Proteins, Tumor Suppressor Proteins
Added July 26, 2012
1 Communities
0 Members
0 Resources
25 MeSH Terms