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Results: 1 to 4 of 4

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2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.
Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK
(2014) Nat Commun 5: 3459
MeSH Terms: Animals, Cell Line, Tumor, Female, Humans, Immunohistochemistry, Mice, Mice, Nude, Phosphates, RNA, Small Interfering, RNA-Induced Silencing Complex, Xenograft Model Antitumor Assays
Added May 27, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide.
Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon GJ, Qi Y
(2008) Cell 133: 116-27
MeSH Terms: Arabidopsis, Arabidopsis Proteins, Argonaute Proteins, MicroRNAs, Nucleotides, RNA, Plant, RNA, Small Interfering, RNA, Untranslated, RNA-Induced Silencing Complex
Added February 15, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M
(2007) Nucleic Acids Res 35: 6424-38
MeSH Terms: Argonaute Proteins, Base Pair Mismatch, Base Pairing, Crystallography, X-Ray, Eukaryotic Initiation Factor-2, Fluorobenzenes, HeLa Cells, Humans, Hydrogen Bonding, Models, Molecular, Nucleotides, Oligoribonucleotides, Osmotic Pressure, RNA Interference, RNA, Small Interfering, RNA-Induced Silencing Complex, Substrate Specificity, Thermodynamics
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.
Sharma AK, Nelson MC, Brandt JE, Wessman M, Mahmud N, Weller KP, Hoffman R
(2001) Blood 97: 426-34
MeSH Terms: Animals, Antigens, CD34, Apoptosis, Argonaute Proteins, Bone Marrow Cells, Cell Culture Techniques, Cell Differentiation, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 12, Cloning, Molecular, DNA, Complementary, Drosophila, Drosophila Proteins, Formazans, Humans, Insect Proteins, Molecular Sequence Data, Proteins, RNA-Induced Silencing Complex, Sequence Alignment, Sequence Homology, Amino Acid, Stem Cells, Tetrazolium Salts, Transfection, Tumor Cells, Cultured
Added November 14, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms