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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.
Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D'Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ
(2016) Cancer Res 76: 6657-6668
MeSH Terms: Animals, Camptothecin, Cell Line, Tumor, Female, Humans, Irinotecan, Mice, Mice, Nude, Oncogene Proteins, Oncogene Proteins, Fusion, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Sarcoma, Ewing
Added June 27, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma.
Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J
(2016) Oncotarget 7: 43504-43517
MeSH Terms: Animals, Antineoplastic Agents, Autocrine Communication, Azepines, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Cell Survival, Epigenesis, Genetic, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Insulin-Like Growth Factor I, Mice, Mice, Nude, NIH 3T3 Cells, Oncogene Proteins, Fusion, Proteins, Proto-Oncogene Protein c-fli-1, Proto-Oncogene Proteins c-akt, RNA-Binding Protein EWS, Receptor, IGF Type 1, Receptors, Somatomedin, Sarcoma, Ewing, Signal Transduction, Transcription, Genetic, Triazoles, Xenograft Model Antitumor Assays
Added November 19, 2016
0 Communities
3 Members
0 Resources
29 MeSH Terms
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203
MeSH Terms: Animals, Antineoplastic Agents, Camptothecin, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, Dioxoles, Disease Models, Animal, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Exodeoxyribonucleases, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Irinotecan, Mice, Oncogene Proteins, Fusion, Phenotype, Proto-Oncogene Protein c-fli-1, RNA Interference, RNA, Small Interfering, RNA-Binding Protein EWS, RecQ Helicases, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Werner Syndrome Helicase, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.
Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ
(2011) J Natl Cancer Inst 103: 962-78
MeSH Terms: Animals, Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Cell Survival, DNA Damage, Dose-Response Relationship, Drug, Gene Expression Regulation, Neoplastic, High-Throughput Screening Assays, Humans, Immunoblotting, Immunohistochemistry, Mice, Microscopy, Confocal, Oncogene Proteins, Fusion, Plicamycin, Protein Array Analysis, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Reverse Transcriptase Polymerase Chain Reaction, Sarcoma, Ewing, Transcription Factors, Transcription, Genetic, Translocation, Genetic, Transplantation, Heterologous
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells.
Grohar PJ, Griffin LB, Yeung C, Chen QR, Pommier Y, Khanna C, Khan J, Helman LJ
(2011) Neoplasia 13: 145-53
MeSH Terms: Antineoplastic Agents, Alkylating, Bone Neoplasms, Cell Line, Tumor, Child, DAX-1 Orphan Nuclear Receptor, Dioxoles, Europe, Gene Expression Regulation, Neoplastic, Humans, Oncogene Proteins, Fusion, Promoter Regions, Genetic, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, RNA-Binding Protein FUS, Sarcoma, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Transcription Factor CHOP
Added September 3, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms
EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice.
Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ
(2007) Mol Cell Biol 27: 7918-34
MeSH Terms: Animals, Cell Line, Cell Proliferation, Chimera, Chromosome Aberrations, GATA1 Transcription Factor, Gene Expression Profiling, Leukemia, Myeloid, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, SCID, Mice, Transgenic, Neoplasm Transplantation, Oncogene Proteins, Fusion, Proteins, Proto-Oncogene Protein c-fli-1, RNA, Untranslated, RNA-Binding Protein EWS, Sarcoma, Ewing, Stem Cells
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Peripheral primitive neuroectodermal tumor/Ewing's sarcoma of the craniospinal vault: case reports and review.
Mobley BC, Roulston D, Shah GV, Bijwaard KE, McKeever PE
(2006) Hum Pathol 37: 845-53
MeSH Terms: 12E7 Antigen, Adult, Antigens, CD, Back Pain, Blotting, Southern, Brain Neoplasms, Cauda Equina, Cell Adhesion Molecules, Chromosome Aberrations, Chromosomes, Human, Pair 22, Diagnosis, Differential, Headache, Humans, Male, Meningioma, Neuroectodermal Tumors, Primitive, Peripheral, Oncogene Proteins, Fusion, Peripheral Nervous System Neoplasms, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Reverse Transcriptase Polymerase Chain Reaction, Sarcoma, Ewing
Added August 14, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms