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Results: 1 to 6 of 6

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The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
Venkateswaran A, Friedman DB, Walsh AJ, Skala MC, Sasi S, Rachakonda G, Crooks PA, Freeman ML, Sekhar KR
(2013) Invest New Drugs 31: 535-44
MeSH Terms: Angiogenesis Inhibitors, Cells, Cultured, Cytoskeletal Proteins, Human Umbilical Vein Endothelial Cells, Humans, Indoles, NAD, NADH, NADPH Oxidoreductases, Proteomics, Quinuclidines
Added March 7, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Targeting mutant p53 in human tumors.
Lehmann BD, Pietenpol JA
(2012) J Clin Oncol 30: 3648-50
MeSH Terms: Antineoplastic Agents, Disease-Free Survival, Female, Humans, Male, Molecular Targeted Therapy, Mutation, Neoplasms, Patient Safety, Quinuclidines, Risk Assessment, Sensitivity and Specificity, Signal Transduction, Survival Analysis, Treatment Outcome, Tumor Suppressor Protein p53
Added September 3, 2013
1 Communities
3 Members
0 Resources
16 MeSH Terms
Antiangiogenic properties of substituted (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol/one analogs and their derivatives.
Venkateswaran A, Reddy YT, Sonar VN, Muthusamy V, Crooks PA, Freeman ML, Sekhar KR
(2010) Bioorg Med Chem Lett 20: 7323-6
MeSH Terms: Angiogenesis Inhibitors, Cell Movement, Endothelial Cells, Endothelium, Vascular, Humans, NADH, NADPH Oxidoreductases, Quinuclidines, Structure-Activity Relationship, Umbilical Veins
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
Geng L, Rachakonda G, Morré DJ, Morré DM, Crooks PA, Sonar VN, Roti JL, Rogers BE, Greco S, Ye F, Salleng KJ, Sasi S, Freeman ML, Sekhar KR
(2009) FASEB J 23: 2986-95
MeSH Terms: Cell Movement, Cell Shape, Cells, Cultured, Drug Evaluation, Preclinical, Endothelial Cells, Endothelium, Vascular, Humans, Indoles, Membrane Proteins, Neoplasms, Neovascularization, Pathologic, Protein Disulfide Reductase (Glutathione), Quinuclidines, Transcription Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents.
Sonar VN, Thirupathi Reddy Y, Sekhar KR, Sasi S, Freeman ML, Crooks PA
(2007) Bioorg Med Chem Lett 17: 6821-4
MeSH Terms: Cell Line, Tumor, Cell Survival, Humans, Molecular Structure, Quinuclidines, Radiation-Sensitizing Agents, Structure-Activity Relationship, Temperature
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols.
Sekhar KR, Crooks PA, Sonar VN, Friedman DB, Chan JY, Meredith MJ, Starnes JH, Kelton KR, Summar SR, Sasi S, Freeman ML
(2003) Cancer Res 63: 5636-45
MeSH Terms: Animals, Anticarcinogenic Agents, Gene Expression Regulation, Enzymologic, Glutamate-Cysteine Ligase, Humans, Indoles, Intracellular Signaling Peptides and Proteins, Kelch-Like ECH-Associated Protein 1, Mice, NADPH Oxidases, Proteins, Quinuclidines, Structure-Activity Relationship, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms