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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 48

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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Tian J, Teuscher KB, Aho ER, Alvarado JR, Mills JJ, Meyers KM, Gogliotti RD, Han C, Macdonald JD, Sai J, Shaw JG, Sensintaffar JL, Zhao B, Rietz TA, Thomas LR, Payne WG, Moore WJ, Stott GM, Kondo J, Inoue M, Coffey RJ, Tansey WP, Stauffer SR, Lee T, Fesik SW
(2020) J Med Chem 63: 656-675
MeSH Terms: Antineoplastic Agents, Bridged Bicyclo Compounds, Heterocyclic, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Chromatin, Crystallography, X-Ray, Drug Design, Drug Discovery, Epigenetic Repression, Genes, myc, Humans, Intracellular Signaling Peptides and Proteins, Quinolones, Structure-Activity Relationship, WD40 Repeats
Added March 3, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Apotransferrin in Combination with Ciprofloxacin Slows Bacterial Replication, Prevents Resistance Amplification, and Increases Antimicrobial Regimen Effect.
Ambrose PG, VanScoy BD, Luna BM, Yan J, Ulhaq A, Nielsen TB, Rudin S, Hujer K, Bonomo RA, Actis L, Skaar E, Spellberg B
(2019) Antimicrob Agents Chemother 63:
MeSH Terms: Anti-Bacterial Agents, Apoproteins, Ciprofloxacin, Fluoroquinolones, Klebsiella, Microbial Sensitivity Tests, Transferrin
Added April 7, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms
Cobicistat Versus Ritonavir: Similar Pharmacokinetic Enhancers But Some Important Differences.
Tseng A, Hughes CA, Wu J, Seet J, Phillips EJ
(2017) Ann Pharmacother 51: 1008-1022
MeSH Terms: Anti-HIV Agents, Atazanavir Sulfate, Cobicistat, Darunavir, Drug Interactions, HIV Infections, Humans, Quinolones, Ritonavir
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Fluoroquinolones for the treatment and prevention of multidrug-resistant tuberculosis.
Sterling TR
(2016) Int J Tuberc Lung Dis 20: 42-47
MeSH Terms: Antitubercular Agents, Clinical Trials as Topic, Dose-Response Relationship, Drug, Fluoroquinolones, Humans, Levofloxacin, Moxifloxacin, Treatment Outcome, Tuberculosis, Multidrug-Resistant
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2.
Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA
(2015) J Med Chem 58: 9027-40
MeSH Terms: Animals, Central Nervous System, Drug Discovery, Mice, Protein Binding, Quinolines, Quinolones, Rats, Receptor, Muscarinic M1, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added February 18, 2016
0 Communities
2 Members
0 Resources
11 MeSH Terms
Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice.
Gould RW, Dencker D, Grannan M, Bubser M, Zhan X, Wess J, Xiang Z, Locuson C, Lindsley CW, Conn PJ, Jones CK
(2015) ACS Chem Neurosci 6: 1683-95
MeSH Terms: Analysis of Variance, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Operant, Discrimination, Psychological, Dose-Response Relationship, Drug, Gene Expression Regulation, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pattern Recognition, Visual, Photic Stimulation, Quinolones, RNA, Messenger, Receptor, Muscarinic M1, Reinforcement Schedule, Reinforcement, Psychology, Touch
Added February 18, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Four-month fluoroquinolone-containing regimens are inferior to standard 6-month tuberculosis treatment.
Sterling TR
(2015) Evid Based Med 20: 128-9
MeSH Terms: Antitubercular Agents, Female, Fluoroquinolones, Humans, Male, Mycobacterium tuberculosis, Tuberculosis, Pulmonary
Added February 17, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
Su Y, Yu CY, Tsai Y, Wang SH, Lee C, Chu C
(2016) J Microbiol Immunol Infect 49: 892-901
MeSH Terms: Animals, Anti-Bacterial Agents, Bacterial Proteins, Cattle, Cloxacillin, Electrophoresis, Gel, Pulsed-Field, Escherichia coli, Escherichia coli Infections, Escherichia coli Proteins, Female, Fluoroquinolones, Mastitis, Bovine, Microbial Sensitivity Tests, Milk, Multiplex Polymerase Chain Reaction, Taiwan, beta-Lactam Resistance, beta-Lactamases
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Han C, Chatterjee A, Noetzel MJ, Panarese JD, Smith E, Chase P, Hodder P, Niswender C, Conn PJ, Lindsley CW, Stauffer SR
(2015) Bioorg Med Chem Lett 25: 384-8
MeSH Terms: Allosteric Regulation, Allosteric Site, Drug Discovery, Humans, Models, Molecular, Molecular Docking Simulation, Molecular Structure, Pyrazoles, Quinolines, Quinolones, Receptor, Muscarinic M1, Small Molecule Libraries, Structure-Activity Relationship
Added February 18, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
A comparison of interview methods to ascertain fluoroquinolone exposure before tuberculosis diagnosis.
Van Der Heijden YF, Maruri F, Holt E, Mitchel E, Warkentin J, Sterling TR
(2015) Epidemiol Infect 143: 960-5
MeSH Terms: Adult, Anti-Bacterial Agents, Databases, Factual, Delayed Diagnosis, Drug Resistance, Bacterial, Female, Fluoroquinolones, Humans, Interviews as Topic, Male, Medical History Taking, Medical Records, Middle Aged, Pharmacies, Surveys and Questionnaires, Tennessee, Tuberculosis, Tuberculosis, Pulmonary
Added February 17, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms