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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 13

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Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
Nguyen L, Robson MJ, Healy JR, Scandinaro AL, Matsumoto RR
(2014) PLoS One 9: e89985
MeSH Terms: Adrenergic alpha-Antagonists, Animals, Antidepressive Agents, Behavior, Animal, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Dextromethorphan, Dose-Response Relationship, Drug, Ethylenediamines, Excitatory Amino Acid Antagonists, Ketamine, Kinetics, Male, Mice, Piperazines, Protein Binding, Quinidine, Receptors, N-Methyl-D-Aspartate, Receptors, sigma, Swimming
Added August 26, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG
(2013) J Biol Chem 288: 4436-51
MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Adrenergic alpha-Antagonists, Animals, Cell Line, Cytochrome P-450 CYP2D6, Dopamine Agents, Dopaminergic Neurons, Dynamins, Humans, Mice, Mitochondria, Mitochondrial Proteins, Parkinsonian Disorders, Quinidine, Reactive Oxygen Species, Ubiquitin-Protein Ligases
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM
(2013) Mol Pharmacol 83: 481-9
MeSH Terms: Alanine, Allosteric Regulation, Animals, Binding Sites, CHO Cells, Cell Line, Cricetinae, Cysteine, Heart, Humans, KCNQ1 Potassium Channel, Models, Molecular, Mutagenesis, Site-Directed, Myocardium, Quinidine
Added May 30, 2013
2 Communities
3 Members
1 Resources
15 MeSH Terms
Inhibition of human cytochrome P450 3A4 by cholesterol.
Shinkyo R, Guengerich FP
(2011) J Biol Chem 286: 18426-33
MeSH Terms: Anti-Arrhythmia Agents, Cells, Cultured, Cholesterol, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Enzyme Inhibitors, Hepatocytes, Humans, Microsomes, Liver, Models, Biological, Nifedipine, Oxidation-Reduction, Quinidine, Vasodilator Agents
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.
McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM
(2009) J Cardiovasc Pharmacol 54: 63-71
MeSH Terms: Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cation Transport Proteins, Electrophysiology, Ether-A-Go-Go Potassium Channels, Flecainide, Gene Expression, Heart, Humans, Immunohistochemistry, In Situ Hybridization, Inhibitory Concentration 50, Myocytes, Cardiac, Organic Cation Transport Proteins, Patch-Clamp Techniques, Potassium Channels, Quinidine, Sulfonamides, Symporters
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation.
Yang T, Kanki H, Zhang W, Roden DM
(2009) Br J Pharmacol 157: 952-61
MeSH Terms: Amino Acid Sequence, Animals, CHO Cells, Cricetinae, Cricetulus, Cyclic AMP-Dependent Protein Kinases, Humans, KCNQ1 Potassium Channel, Molecular Sequence Data, Phosphorylation, Potassium Channel Blockers, Potassium Channels, Voltage-Gated, Quinidine
Added June 26, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives.
Kannankeril PJ, Roden DM, Norris KJ, Whalen SP, George AL, Murray KT
(2005) Heart Rhythm 2: 134-40
MeSH Terms: Anti-Arrhythmia Agents, Electrocardiography, Female, Genetic Predisposition to Disease, Humans, Long QT Syndrome, Male, Middle Aged, Quinidine
Added January 20, 2015
0 Communities
1 Members
0 Resources
9 MeSH Terms
Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
Guengerich FP, Hanna IH, Martin MV, Gillam EM
(2003) Biochemistry 42: 1245-53
MeSH Terms: Amines, Amino Acid Substitution, Binding Sites, Catalysis, Cytochrome P-450 CYP2D6, Ethanolamines, Glutamic Acid, Glutamine, Humans, Hydroxylation, Methylation, Mutagenesis, Site-Directed, Oxidation-Reduction, Protein Binding, Quinidine, Recombinant Proteins, Spiro Compounds, Static Electricity, Substrate Specificity, Sulfonamides, Tyramine
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Coumarin substrates for cytochrome P450 2D6 fluorescence assays.
Nakamura K, Hanna IH, Cai H, Nishimura Y, Williams KM, Guengerich FP
(2001) Anal Biochem 292: 280-6
MeSH Terms: Amino Acid Sequence, Catalysis, Coumarins, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2D6 Inhibitors, Enzyme Inhibitors, Fluorescent Dyes, Humans, Kinetics, Microsomes, Liver, Molecular Sequence Data, Quinidine, Recombinant Proteins, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments].
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM
(1999) Circulation 99: 552-7
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Biological Transport, Active, Caco-2 Cells, Cardiovascular Agents, Digoxin, Drug Interactions, Drug Resistance, Multiple, Humans, Mice, Quinidine, Tissue Distribution
Added December 10, 2013
0 Communities
1 Members
0 Resources
12 MeSH Terms