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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 9 of 9

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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α.
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2019) Biochemistry 58: 5102-5106
MeSH Terms: Biocatalysis, Casein Kinase Ialpha, Enzyme Activation, HEK293 Cells, Humans, Kinetics, Pyrvinium Compounds
Added December 22, 2019
0 Communities
1 Members
0 Resources
7 MeSH Terms
Pharmacologic Inhibition of β-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor.
Polosukhina D, Love HD, Moses HL, Lee E, Zent R, Clark PE
(2017) Oncol Res 25: 1653-1664
MeSH Terms: Animals, Anthelmintics, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Humans, Mice, Pyrvinium Compounds, Signal Transduction, Transcription, Genetic, Wilms Tumor, Wnt Signaling Pathway, beta Catenin
Added July 18, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ
(2017) Sci Signal 10:
MeSH Terms: Animals, Antineoplastic Agents, Benzoates, Casein Kinase Ialpha, Enzyme Activation, Enzyme Activators, Gene Expression Regulation, Neoplastic, HCT116 Cells, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Neoplasm Metastasis, Neoplasms, Organ Culture Techniques, Phosphorylation, Pyrvinium Compounds, Signal Transduction, Surface Plasmon Resonance, Wnt Proteins, Wnt Signaling Pathway, Xenograft Model Antitumor Assays, Xenopus laevis
Added July 18, 2017
0 Communities
1 Members
0 Resources
24 MeSH Terms
Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.
Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ
(2014) PLoS One 9: e101969
MeSH Terms: Adenomatous Polyposis Coli, Animals, Antineoplastic Agents, Cell Survival, Drug Approval, Drug Repositioning, Drug Screening Assays, Antitumor, HCT116 Cells, Humans, Mice, Inbred C57BL, Mice, Transgenic, Pyrvinium Compounds, Wnt Signaling Pathway
Added November 2, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Pyrvinium attenuates Hedgehog signaling downstream of smoothened.
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ
(2014) Cancer Res 74: 4811-21
MeSH Terms: Animals, Carcinoma, Basal Cell, Casein Kinase Ialpha, Cell Line, HEK293 Cells, Hedgehog Proteins, Humans, Medulloblastoma, Mice, Mice, Nude, NIH 3T3 Cells, Oncogene Proteins, Pyrvinium Compounds, Receptors, G-Protein-Coupled, Signal Transduction, Trans-Activators, Transcription Factors, Zinc Finger Protein GLI1
Added November 2, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Targeting the Wnt pathway in synovial sarcoma models.
Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE
(2013) Cancer Discov 3: 1286-301
MeSH Terms: Adolescent, Adult, Animals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Gene Knockout Techniques, Humans, Mice, Mice, Nude, Mice, Transgenic, Oncogene Proteins, Fusion, Pyrvinium Compounds, Sarcoma, Experimental, Sarcoma, Synovial, Wnt Signaling Pathway, Xenograft Model Antitumor Assays, Young Adult
Added August 29, 2013
2 Communities
6 Members
0 Resources
17 MeSH Terms
Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs).
Saraswati S, Deskins DL, Holt GE, Young PP
(2012) Wound Repair Regen 20: 185-93
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Cells, Cultured, Granulation Tissue, Mesenchymal Stem Cells, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, SCID, Pyrvinium Compounds, Signal Transduction, Wnt Proteins, Wound Healing, beta Catenin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.
Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP
(2010) PLoS One 5: e15521
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Axin Protein, Casein Kinase Ialpha, Cell Proliferation, Chemokines, Enzyme Activation, Gene Expression, HEK293 Cells, Heart, Humans, Immunoblotting, Intercellular Signaling Peptides and Proteins, Mice, Myocardial Infarction, Myocardium, Proto-Oncogene Proteins c-myc, Pyrvinium Compounds, Repressor Proteins, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Ventricular Remodeling, Wnt Proteins, Wound Healing, beta Catenin
Added March 5, 2014
0 Communities
2 Members
0 Resources
25 MeSH Terms
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
(2010) Nat Chem Biol 6: 829-36
MeSH Terms: Adaptor Proteins, Signal Transducing, Adenomatous Polyposis Coli, Animals, Axin Protein, Casein Kinase I, Casein Kinase Ialpha, Cell Extracts, Cell Line, Tumor, Cell Proliferation, Colonic Neoplasms, Dose-Response Relationship, Drug, Enzyme Activation, Enzyme Inhibitors, Humans, Intracellular Signaling Peptides and Proteins, Oocytes, Pyrvinium Compounds, Repressor Proteins, Signal Transduction, Wnt Proteins, Xenopus Proteins, Xenopus laevis, beta Catenin
Added February 3, 2014
0 Communities
5 Members
0 Resources
23 MeSH Terms