Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 49

Publication Record

Connections

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.
Roby DA, Ruiz F, Kermath BA, Voorhees JR, Niehoff M, Zhang J, Morley JE, Musiek ES, Farr SA, Burris TP
(2019) PLoS One 14: e0215004
MeSH Terms: Alzheimer Disease, Amyloid beta-Peptides, Animals, Cognitive Dysfunction, Disease Models, Animal, Disks Large Homolog 4 Protein, Hippocampus, Male, Mice, Nuclear Receptor Subfamily 1, Group D, Member 1, Peptide Fragments, Pyrrolidines, Thiophenes
Added April 30, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Advocating for mutually beneficial access to shelved compounds.
Pulley JM, Jerome RN, Shirey-Rice JK, Zaleski NM, Naylor HM, Pruijssers AJ, Jackson JC, Bernard GR, Holroyd KJ
(2018) Future Med Chem 10: 1395-1398
MeSH Terms: Antidiuretic Hormone Receptor Antagonists, Anxiety Disorders, Depressive Disorder, Major, Drug Industry, Drug Repositioning, Humans, Indoles, Pyrrolidines, Receptors, Vasopressin
Added March 26, 2019
0 Communities
2 Members
0 Resources
MeSH Terms
FTO affects food cravings and interacts with age to influence age-related decline in food cravings.
Dang LC, Samanez-Larkin GR, Smith CT, Castrellon JJ, Perkins SF, Cowan RL, Claassen DO, Zald DH
(2018) Physiol Behav 192: 188-193
MeSH Terms: Adult, Aged, Aged, 80 and over, Aging, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Benzamides, Body Mass Index, Brain, Craving, Feeding Behavior, Female, Food, Genetic Association Studies, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Positron-Emission Tomography, Pyrrolidines, Radiopharmaceuticals, Receptors, Dopamine D2, Young Adult
Added March 21, 2018
0 Communities
3 Members
0 Resources
22 MeSH Terms
Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition.
Suzuki T, Tada Y, Gladson S, Nishimura R, Shimomura I, Karasawa S, Tatsumi K, West J
(2017) Respir Res 18: 177
MeSH Terms: Adamantane, Animals, Dipeptidyl-Peptidase IV Inhibitors, Epithelial-Mesenchymal Transition, Lipopolysaccharides, Lung Injury, Male, Mice, Mice, Inbred C57BL, Nitriles, Pulmonary Fibrosis, Pyrrolidines, Vildagliptin
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A
(2017) EBioMedicine 24: 43-55
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Azepines, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA Damage, DNA Replication, HCT116 Cells, Humans, Imidazoles, Melanoma, Mice, Piperazines, Protein Binding, Proto-Oncogene Proteins c-mdm2, Pyrimidines, Pyrrolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, para-Aminobenzoates
Added June 20, 2018
1 Communities
2 Members
0 Resources
MeSH Terms
Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults.
Dang LC, Samanez-Larkin GR, Castrellon JJ, Perkins SF, Cowan RL, Newhouse PA, Zald DH
(2017) eNeuro 4:
MeSH Terms: Adult, Benzamides, Blinking, Brain, Bromocriptine, Dopamine Agonists, Dopamine D2 Receptor Antagonists, Double-Blind Method, Female, Healthy Volunteers, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Pyrrolidines, Receptors, Dopamine D2, Young Adult
Added March 21, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
Associations between dopamine D2 receptor availability and BMI depend on age.
Dang LC, Samanez-Larkin GR, Castrellon JJ, Perkins SF, Cowan RL, Zald DH
(2016) Neuroimage 138: 176-183
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Benzamides, Biological Availability, Body Mass Index, Brain, Female, Humans, Male, Middle Aged, Molecular Imaging, Positron-Emission Tomography, Pyrrolidines, Radiopharmaceuticals, Receptors, Dopamine D2, Receptors, Dopamine D3, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic, Tissue Distribution, Young Adult
Added April 6, 2017
0 Communities
1 Members
0 Resources
24 MeSH Terms
Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.
Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS
(2015) Antioxid Redox Signal 22: 1633-45
MeSH Terms: Aldehydes, Animals, Humans, Inflammation, Lipids, Macrophages, Male, Mice, Inbred C57BL, Mice, Knockout, NF-kappa B, Phosphatidylethanolamines, Prostaglandins E, Pyrrolidines, Receptor for Advanced Glycation End Products
Added October 8, 2015
2 Communities
2 Members
0 Resources
14 MeSH Terms
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW
(2014) J Med Chem 57: 10192-7
MeSH Terms: Allosteric Regulation, Animals, Catalepsy, Central Nervous System Agents, Drug Synergism, Exenatide, Glucagon-Like Peptide 1, Glucagon-Like Peptide-1 Receptor, Haloperidol, High-Throughput Screening Assays, Indoles, Insulin, Insulin Secretion, Islets of Langerhans, Male, Mice, Inbred C57BL, Microsomes, Liver, Peptides, Pyrrolidines, Receptors, Glucagon, Structure-Activity Relationship, Venoms
Added February 16, 2015
0 Communities
4 Members
0 Resources
22 MeSH Terms
Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence.
Simmler LD, Wandeler R, Liechti ME
(2013) BMC Res Notes 6: 220
MeSH Terms: Amphetamine-Related Disorders, Benzodioxoles, Biological Transport, Bupropion, Dopamine, Humans, Methamphetamine, Methylphenidate, Pyrrolidines
Added August 3, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms