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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 82

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Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism.
Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD
(2018) Circ Res 123: e51-e64
MeSH Terms: Angiogenesis Inhibitors, Animals, Arterioles, Cell Lineage, Cells, Cultured, Hypertension, Pulmonary, Indoles, Lung, Mice, Mice, Inbred C57BL, Myeloid Progenitor Cells, Pyrroles, Receptor, Serotonin, 5-HT2B, Vascular Stiffness
Added April 2, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Toxicity and repair of DNA adducts produced by the natural product yatakemycin.
Mullins EA, Shi R, Eichman BF
(2017) Nat Chem Biol 13: 1002-1008
MeSH Terms: Biological Products, DNA Adducts, DNA Damage, DNA Repair, Drug Resistance, Bacterial, Duocarmycins, Indoles, Molecular Structure, Pyrroles
Added August 26, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4).
Gogliotti RD, Blobaum AL, Morrison RM, Daniels JS, Salovich JM, Cheung YY, Rodriguez AL, Loch MT, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
(2016) Bioorg Med Chem Lett 26: 2984-2987
MeSH Terms: Allosteric Regulation, Animals, Microsomes, Liver, Picolinic Acids, Pyrroles, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship, Sulfonamides, Triazoles
Added April 6, 2017
0 Communities
2 Members
0 Resources
10 MeSH Terms
Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.
Panarese JD, Cho HP, Adams JJ, Nance KD, Garcia-Barrantes PM, Chang S, Morrison RD, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW
(2016) Bioorg Med Chem Lett 26: 3822-5
MeSH Terms: Allosteric Regulation, Animals, Central Nervous System, Central Nervous System Agents, Dose-Response Relationship, Drug, Drug Discovery, Heterocyclic Compounds, Molecular Structure, Pyridines, Pyrroles, Rats, Receptor, Muscarinic M1, Structure-Activity Relationship
Added April 6, 2017
0 Communities
2 Members
0 Resources
13 MeSH Terms
The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.
Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF
(2015) Nature 527: 254-8
MeSH Terms: Bacillus cereus, Base Pairing, Biocatalysis, Catalytic Domain, Crystallography, X-Ray, DNA Adducts, DNA Damage, DNA Glycosylases, DNA Repair, Duocarmycins, Indoles, Models, Molecular, Pyrroles
Added November 10, 2015
1 Communities
1 Members
0 Resources
13 MeSH Terms
Differential CaMKII regulation by voltage-gated calcium channels in the striatum.
Pasek JG, Wang X, Colbran RJ
(2015) Mol Cell Neurosci 68: 234-43
MeSH Terms: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Animals, Calcium, Calcium Channel Agonists, Calcium Channel Blockers, Calcium Channels, L-Type, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Chelating Agents, Corpus Striatum, Egtazic Acid, Enzyme Inhibitors, Gene Expression Regulation, In Vitro Techniques, Male, Mice, Mice, Inbred C57BL, Pyrroles, Receptors, Glutamate, Signal Transduction, Spider Venoms
Added February 15, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Ghoshal A, Rook JM, Dickerson JW, Roop GN, Morrison RD, Jalan-Sakrikar N, Lamsal A, Noetzel MJ, Poslusney MS, Wood MR, Melancon BJ, Stauffer SR, Xiang Z, Daniels JS, Niswender CM, Jones CK, Lindsley CW, Conn PJ
(2016) Neuropsychopharmacology 41: 598-610
MeSH Terms: Animals, Antipsychotic Agents, Cognition, Disease Models, Animal, Long-Term Synaptic Depression, Male, Mice, Inbred C57BL, Mice, Knockout, Patch-Clamp Techniques, Phencyclidine, Pyridines, Pyrroles, Receptor, Muscarinic M1, Schizophrenia, Schizophrenic Psychology, Social Behavior
Added February 18, 2016
0 Communities
4 Members
0 Resources
16 MeSH Terms
Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach.
Deng Z, Lubinski AJ, Page TL
(2015) Neurobiol Learn Mem 118: 89-95
MeSH Terms: Animals, Benzophenanthridines, Carbazoles, Cell-Penetrating Peptides, Cockroaches, Conditioning, Psychological, Lipopeptides, Memory, Long-Term, Protein Kinase Inhibitors, Protein Synthesis Inhibitors, Pyrroles
Added January 20, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7.
Jalan-Sakrikar N, Field JR, Klar R, Mattmann ME, Gregory KJ, Zamorano R, Engers DW, Bollinger SR, Weaver CD, Days EL, Lewis LM, Utley TJ, Hurtado M, Rigault D, Acher F, Walker AG, Melancon BJ, Wood MR, Lindsley CW, Conn PJ, Xiang Z, Hopkins CR, Niswender CM
(2014) ACS Chem Neurosci 5: 1221-37
MeSH Terms: Acetanilides, Animals, Benzoates, CHO Cells, Calcium, Cricetulus, Dose-Response Relationship, Drug, Excitatory Amino Acid Agents, Excitatory Postsynaptic Potentials, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Glutamic Acid, Glycine, HEK293 Cells, Hippocampus, Humans, In Vitro Techniques, Male, Mice, Inbred C57BL, Picolinic Acids, Propionates, Pyrroles, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship, Thallium, Transfection
Added February 16, 2015
0 Communities
3 Members
0 Resources
26 MeSH Terms
Characterization of statin dose response in electronic medical records.
Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, Wilke RA, Denny JC
(2014) Clin Pharmacol Ther 95: 331-8
MeSH Terms: Algorithms, Alleles, Atorvastatin, Cholesterol, LDL, Cohort Studies, Databases, Factual, Dose-Response Relationship, Drug, Electronic Health Records, Genotype, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hyperlipidemias, Lipid Metabolism, Lipids, Phenotype, Polymorphism, Single Nucleotide, Pyrroles, Randomized Controlled Trials as Topic, Simvastatin
Added May 27, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms