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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M
(2018) Xenobiotica 48: 565-575
MeSH Terms: Alleles, Aryl Hydrocarbon Hydroxylases, Biocatalysis, Cytochrome P-450 CYP1B1, Humans, Molecular Docking Simulation, Oxidation-Reduction, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13.
Shimada T, Takenaka S, Murayama N, Kramlinger VM, Kim JH, Kim D, Liu J, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2016) Xenobiotica 46: 211-24
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP2A6, Humans, Lepidoptera, Models, Biological, Molecular Docking Simulation, Oxidation-Reduction, Polycyclic Compounds, Pyrenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Polycyclic aromatic hydrocarbons: determinants of urinary 1-hydroxypyrene glucuronide concentration and risk of colorectal cancer in the Shanghai Women's Health Study.
Hofmann JN, Liao LM, Strickland PT, Shu XO, Yang G, Ji BT, Li HL, Rothman N, Kamangar F, Gao YT, Zheng W, Chow WH
(2013) BMC Cancer 13: 282
MeSH Terms: Case-Control Studies, Chromatography, Affinity, Colorectal Neoplasms, Female, Glucuronates, Humans, Middle Aged, Polycyclic Aromatic Hydrocarbons, Pyrenes, Risk Factors
Added May 4, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.
Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M
(2009) Chem Res Toxicol 22: 1325-33
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biphenyl Compounds, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Flavonoids, Humans, Hydrocarbons, Aromatic, Kinetics, Naphthalenes, Phenanthrenes, Protein Binding, Pyrenes, Spectrophotometry, Ultraviolet, Stilbenes, Structure-Activity Relationship
Added March 26, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding.
Sohl CD, Isin EM, Eoff RL, Marsch GA, Stec DF, Guengerich FP
(2008) J Biol Chem 283: 7293-308
MeSH Terms: Animals, Cytochrome P-450 CYP1A2, Dose-Response Relationship, Drug, Humans, Kinetics, Ligands, Magnetic Resonance Spectroscopy, Models, Biological, Models, Chemical, Oxygen, Protein Binding, Pyrenes, Rabbits, Spectrometry, Fluorescence, Substrate Specificity
Added March 5, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms
Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.
Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K
(2004) Chem Res Toxicol 17: 1077-85
MeSH Terms: Animals, Aryl Hydrocarbon Hydroxylases, Breast, Breast Neoplasms, Cell Line, Tumor, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1B1, DNA Adducts, Environmental Pollutants, Epithelial Cells, Female, Humans, Isomerism, Nitro Compounds, Oxidation-Reduction, Pyrenes, Rats, Recombinant Proteins, Tumor Cells, Cultured
Added May 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay.
Hatanaka N, Yamazaki H, Oda Y, Guengerich FP, Nakajima M, Yokoi T
(2001) Mutat Res 497: 223-33
MeSH Terms: Acetyltransferases, Aryl Hydrocarbon Hydroxylases, Biotransformation, Carcinogens, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, In Vitro Techniques, Microsomes, Liver, Mutagens, NADPH-Ferrihemoprotein Reductase, Pyrenes, Recombinant Proteins, SOS Response, Genetics, Salmonella typhimurium
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.
Yamazaki H, Hatanaka N, Kizu R, Hayakawa K, Shimada N, Guengerich FP, Nakajima M, Yokoi T
(2000) Mutat Res 472: 129-38
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biotransformation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme System, Escherichia coli, Humans, Mutagenicity Tests, Mutagens, NADPH-Ferrihemoprotein Reductase, Pyrenes, Recombinant Fusion Proteins, Salmonella typhimurium, Structure-Activity Relationship, Vehicle Emissions
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines.
Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP
(1999) Mutat Res 429: 199-208
MeSH Terms: Amines, Bacterial Proteins, Cytochrome P-450 CYP1A2, DNA-Directed DNA Polymerase, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Humans, Mutagenesis, Mutagenicity Tests, Mutagens, Plasmids, Pyrenes, Quinolines
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype.
Guengerich FP, Parikh A, Turesky RJ, Josephy PD
(1999) Mutat Res 428: 115-24
MeSH Terms: Amino Acid Substitution, Animals, Carcinogens, Environmental, Cytochrome P-450 CYP1A2, Humans, Liver, Mutagenicity Tests, Mutagens, Pyrenes, Rats, Species Specificity, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms