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Neutrophilic inflammation during lung development disrupts elastin assembly and predisposes adult mice to COPD.
Benjamin JT, Plosa EJ, Sucre JM, van der Meer R, Dave S, Gutor S, Nichols DS, Gulleman PM, Jetter CS, Han W, Xin M, Dinella PC, Catanzarite A, Kook S, Dolma K, Lal CV, Gaggar A, Blalock JE, Newcomb DC, Richmond BW, Kropski JA, Young LR, Guttentag SH, Blackwell TS
(2021) J Clin Invest 131:
MeSH Terms: Animals, Elastin, Inflammation, Leukocyte Elastase, Mice, Mice, Transgenic, Neutrophils, Pulmonary Alveoli, Pulmonary Disease, Chronic Obstructive
Added October 30, 2020
1 Communities
0 Members
0 Resources
9 MeSH Terms
Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome.
McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA
(2018) Am J Respir Crit Care Med 197: 1027-1035
MeSH Terms: Aged, Diagnostic Techniques, Respiratory System, Female, Gelatin Sponge, Absorbable, Humans, Male, Middle Aged, Minimally Invasive Surgical Procedures, Pulmonary Alveoli, Respiration, Artificial, Respiratory Distress Syndrome
Added May 31, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome.
Young LR, Gulleman PM, Short CW, Tanjore H, Sherrill T, Qi A, McBride AP, Zaynagetdinov R, Benjamin JT, Lawson WE, Novitskiy SV, Blackwell TS
(2016) JCI Insight 1: e88947
MeSH Terms: Animals, Bleomycin, Chemokine CCL2, Disease Susceptibility, Epithelial Cells, Female, Hermanski-Pudlak Syndrome, Macrophages, Male, Mice, Mice, Inbred C57BL, Protein Serine-Threonine Kinases, Pulmonary Alveoli, Pulmonary Fibrosis, Receptor, Transforming Growth Factor-beta Type II, Receptors, CCR2, Receptors, Transforming Growth Factor beta, Transforming Growth Factor beta
Added March 29, 2017
1 Communities
2 Members
0 Resources
18 MeSH Terms
Prenatal Diagnosis of Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins.
Prothro SL, Plosa E, Markham M, Szafranski P, Stankiewicz P, Killen SA
(2016) J Pediatr 170: 317-8
MeSH Terms: Adult, Chorionic Villi Sampling, Fatal Outcome, Female, Forkhead Transcription Factors, Gene Deletion, Genetic Markers, Humans, Persistent Fetal Circulation Syndrome, Pregnancy, Pulmonary Alveoli, Pulmonary Veins
Added March 18, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Transbronchial Cryobiopsies in the Evaluation of Lung Allografts: Do the Benefits Outweigh the Risks?
Roden AC, Kern RM, Aubry MC, Jenkins SM, Yi ES, Scott JP, Maldonado F
(2016) Arch Pathol Lab Med 140: 303-11
MeSH Terms: Adult, Allografts, Biopsy, Cryopreservation, Female, Hemorrhage, Humans, Lung, Male, Middle Aged, Pulmonary Alveoli, Reproducibility of Results, Risk
Added February 1, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor.
Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA
(2015) Am J Respir Cell Mol Biol 53: 719-27
MeSH Terms: Acute Lung Injury, Animals, Blood Coagulation, Capillary Permeability, Disease Models, Animal, Epithelial Cells, Gene Expression, Hemorrhage, Lipopolysaccharides, Mice, Mice, Knockout, Myeloid Cells, Pulmonary Alveoli, Respiratory Distress Syndrome, Respiratory Mucosa, Thromboplastin
Added February 12, 2016
0 Communities
2 Members
0 Resources
16 MeSH Terms
p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response.
Chignalia AZ, Vogel SM, Reynolds AB, Mehta D, Dull RO, Minshall RD, Malik AB, Liu Y
(2015) Am J Pathol 185: 1251-63
MeSH Terms: Alveolar Epithelial Cells, Animals, Blotting, Western, Capillary Permeability, Catenins, Female, Immunity, Innate, Immunohistochemistry, Inflammation, Lung, Male, Mice, Mice, Knockout, Pulmonary Alveoli, Real-Time Polymerase Chain Reaction
Added May 2, 2016
1 Communities
1 Members
0 Resources
15 MeSH Terms
Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.
Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R
(2014) Development 141: 4751-62
MeSH Terms: Animals, Bronchoalveolar Lavage, Cell Adhesion, Cell Movement, Chemokine CCL2, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Extracellular Matrix, Integrases, Integrin beta1, Lung, Mice, Microscopy, Confocal, Organogenesis, Pulmonary Alveoli, Pulmonary Surfactant-Associated Protein C, Reactive Oxygen Species, Thiobarbituric Acid Reactive Substances
Added January 20, 2015
1 Communities
4 Members
0 Resources
18 MeSH Terms
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.
Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP
(2014) Am J Respir Crit Care Med 189: 214-22
MeSH Terms: Animals, Biomedical Research, Disease Models, Animal, Extracellular Matrix, Genetic Predisposition to Disease, Humans, Idiopathic Pulmonary Fibrosis, Inflammation, Mice, Pulmonary Alveoli, Respiratory Mucosa
Added March 7, 2014
1 Communities
3 Members
0 Resources
11 MeSH Terms
Animal models of fibrotic lung disease.
B Moore B, Lawson WE, Oury TD, Sisson TH, Raghavendran K, Hogaboam CM
(2013) Am J Respir Cell Mol Biol 49: 167-79
MeSH Terms: Animals, Cell Communication, Disease Models, Animal, Epithelial Cells, Genetic Diseases, Inborn, Humans, Lung Diseases, Interstitial, Pulmonary Alveoli, Pulmonary Fibrosis, Respiratory Distress Syndrome, Respiratory Mucosa
Added May 27, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms