Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 37

Publication Record

Connections

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors.
Friggeri L, Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI
(2019) J Med Chem 62: 10391-10401
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Catalytic Domain, Crystallography, X-Ray, Drug Design, Humans, Molecular Structure, Mutagenesis, Site-Directed, Protozoan Proteins, Sterol 14-Demethylase
Added March 3, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC
(2019) ACS Infect Dis 5: 365-371
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Humans, Male, Mice, Nitroimidazoles, Protozoan Proteins, Sterol 14-Demethylase, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Dynamics of CYP51: implications for function and inhibitor design.
Yu X, Cojocaru V, Mustafa G, Salo-Ahen OM, Lepesheva GI, Wade RC
(2015) J Mol Recognit 28: 59-73
MeSH Terms: Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 CYP2C9, Drug Design, Humans, Hydrogen Bonding, Molecular Dynamics Simulation, Protein Structure, Secondary, Protozoan Proteins, Solvents, Sterol 14-Demethylase, Substrate Specificity, Trypanosoma brucei brucei
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Coffee rings as low-resource diagnostics: detection of the malaria biomarker Plasmodium falciparum histidine-rich protein-II using a surface-coupled ring of Ni(II)NTA gold-plated polystyrene particles.
Gulka CP, Swartz JD, Trantum JR, Davis KM, Peak CM, Denton AJ, Haselton FR, Wright DW
(2014) ACS Appl Mater Interfaces 6: 6257-63
MeSH Terms: Animals, Antigens, Protozoan, Biomarkers, Gold, Malaria, Falciparum, Microscopy, Electron, Transmission, Plasmodium falciparum, Polystyrenes, Protozoan Proteins, Surface Properties, Titanium
Added May 27, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Loss of the histidine kinase DhkD results in mobile mounds during development of Dictyostelium discoideum.
Singleton CK, Xiong Y
(2013) PLoS One 8: e75618
MeSH Terms: 3',5'-Cyclic-AMP Phosphodiesterases, Cyclic AMP, Dictyostelium, Genome, Protozoan, Histidine Kinase, Phenotype, Protein Kinases, Protozoan Proteins
Added March 7, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
Hargrove TY, Wawrzak Z, Alexander PW, Chaplin JH, Keenan M, Charman SA, Perez CJ, Waterman MR, Chatelain E, Lepesheva GI
(2013) J Biol Chem 288: 31602-15
MeSH Terms: 14-alpha Demethylase Inhibitors, Antiprotozoal Agents, Chagas Disease, Crystallography, X-Ray, Humans, Protozoan Proteins, Sterol 14-Demethylase, Thiazoles, Triazoles, Trypanosoma cruzi
Added March 7, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Randomized, placebo-controlled trial to assess the safety and immunogenicity of an adenovirus type 35-based circumsporozoite malaria vaccine in healthy adults.
Creech CB, Dekker CL, Ho D, Phillips S, Mackey S, Murray-Krezan C, Grazia Pau M, Hendriks J, Brown V, Dally LG, Versteege I, Edwards KM
(2013) Hum Vaccin Immunother 9: 2548-57
MeSH Terms: Adenoviruses, Human, Adolescent, Adult, Antibodies, Protozoan, Antigens, Protozoan, Drug Carriers, Drug-Related Side Effects and Adverse Reactions, Enzyme-Linked Immunosorbent Assay, Female, Genetic Vectors, Humans, Malaria, Malaria Vaccines, Middle Aged, Placebos, Protozoan Proteins, Treatment Outcome, Vaccination, Vaccines, Synthetic, Young Adult
Added February 3, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Soeiro Mde N, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI
(2013) Antimicrob Agents Chemother 57: 4151-63
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Drug Resistance, Endoplasmic Reticulum, Golgi Apparatus, Imidazoles, Male, Mice, Microscopy, Electron, Transmission, Nitroimidazoles, Oxadiazoles, Protozoan Proteins, Sterol 14-Demethylase, Thiazoles, Triazoles, Trypanocidal Agents, Trypanosoma cruzi
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Membrane and actin reorganization in electropulse-induced cell fusion.
Gerisch G, Ecke M, Neujahr R, Prassler J, Stengl A, Hoffmann M, Schwarz US, Neumann E
(2013) J Cell Sci 126: 2069-78
MeSH Terms: Actins, Cell Fusion, Cell Membrane, Dictyostelium, Giant Cells, Green Fluorescent Proteins, Protozoan Proteins
Added September 6, 2013
0 Communities
0 Members
1 Resources
7 MeSH Terms
Low-resource method for extracting the malarial biomarker histidine-rich protein II to enhance diagnostic test performance.
Davis KM, Swartz JD, Haselton FR, Wright DW
(2012) Anal Chem 84: 6136-42
MeSH Terms: Amino Acid Motifs, Antigens, Protozoan, Biomarkers, Buffers, Chemical Fractionation, Humans, Limit of Detection, Malaria, Protozoan Proteins
Added May 27, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms