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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 18

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amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M
(2018) Proc Natl Acad Sci U S A 115: E6030-E6038
MeSH Terms: Cell Line, Tumor, DNA Transposable Elements, Drug Resistance, Neoplasm, Enzyme Inhibitors, ErbB Receptors, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Proto-Oncogene Proteins c-fyn, Proto-Oncogene Proteins c-yes, Proto-Oncogene Proteins pp60(c-src)
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Proteogenomic characterization of human colon and rectal cancer.
Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC, NCI CPTAC
(2014) Nature 513: 382-7
MeSH Terms: Chromosomes, Human, Pair 20, Colonic Neoplasms, CpG Islands, DNA Copy Number Variations, DNA Methylation, Genomics, Hepatocyte Nuclear Factor 4, Humans, Microsatellite Repeats, Mitochondrial Membrane Transport Proteins, Mitochondrial Precursor Protein Import Complex Proteins, Mutation, Missense, Neoplasm Proteins, Point Mutation, Proteome, Proteomics, Proto-Oncogene Mas, Proto-Oncogene Proteins pp60(c-src), RNA, Messenger, RNA, Neoplasm, Rectal Neoplasms, Transcriptome
Added December 4, 2014
0 Communities
3 Members
0 Resources
22 MeSH Terms
Suppression of hepatic glucose production by human neutrophil alpha-defensins through a signaling pathway distinct from insulin.
Liu HY, Collins QF, Moukdar F, Zhuo D, Han J, Hong T, Collins S, Cao W
(2008) J Biol Chem 283: 12056-63
MeSH Terms: Animals, Blood Glucose, Cell Line, Tumor, Cell Separation, Forkhead Box Protein O1, Forkhead Transcription Factors, Gluconeogenesis, Glucose, Hepatocytes, Humans, Insulin, Liver, Mice, Phosphorylation, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins pp60(c-src), Rats, Rats, Zucker, Signal Transduction, Transcription, Genetic, alpha-Defensins
Added July 23, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression.
Yang S, Park K, Turkson J, Arteaga CL
(2008) Exp Cell Res 314: 413-9
MeSH Terms: ErbB Receptors, Erlotinib Hydrochloride, Genes, myc, Humans, Ligands, Mutation, Phosphorylation, Proto-Oncogene Proteins pp60(c-src), Quinazolines, STAT5 Transcription Factor, Signal Transduction, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.
Siesser PM, Meenderink LM, Ryzhova L, Michael KE, Dumbauld DW, García AJ, Kaverina I, Hanks SK
(2008) Cell Motil Cytoskeleton 65: 25-39
MeSH Terms: Actins, Animals, Cells, Cultured, Focal Adhesion Kinase 1, Focal Adhesions, Genes, src, Mice, Phenotype, Proto-Oncogene Proteins pp60(c-src), Recombinant Fusion Proteins, Signal Transduction
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events.
Werdich XQ, Penn JS
(2005) Angiogenesis 8: 315-26
MeSH Terms: Cell Movement, Cells, Cultured, Down-Regulation, Endothelial Cells, Endothelium, Vascular, Humans, Microvessels, Mitogens, Mitosis, Proto-Oncogene Proteins c-fyn, Proto-Oncogene Proteins c-yes, Proto-Oncogene Proteins pp60(c-src), RNA, Small Interfering, Retinal Vessels, Signal Transduction, Vascular Endothelial Growth Factor A
Added October 9, 2013
1 Communities
1 Members
0 Resources
16 MeSH Terms
Identification of Src phosphorylation sites in the catenin p120ctn.
Mariner DJ, Anastasiadis P, Keilhack H, Böhmer FD, Wang J, Reynolds AB
(2001) J Biol Chem 276: 28006-13
MeSH Terms: Animals, Binding Sites, Blotting, Western, COS Cells, Catenins, Cell Adhesion Molecules, Cell Line, Cytoplasm, DNA Mutational Analysis, Electrophoresis, Gel, Two-Dimensional, Epidermal Growth Factor, Gene Deletion, Genes, Dominant, Glutathione Transferase, Humans, Mutagenesis, Site-Directed, Mutation, Phenylalanine, Phosphoproteins, Phosphorylation, Precipitin Tests, Protein Binding, Protein Structure, Tertiary, Proto-Oncogene Proteins pp60(c-src), Transfection, Tyrosine, Vanadates
Added March 5, 2014
1 Communities
1 Members
0 Resources
27 MeSH Terms
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.
Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM
(1998) Genes Dev 12: 1415-24
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Bone Marrow, Cysteine Endopeptidases, Cytoskeletal Proteins, Fusion Proteins, bcr-abl, Gene Expression Regulation, Leukemic, Homeodomain Proteins, Humans, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Mice, Multienzyme Complexes, Neoplasm Proteins, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-abl, Proto-Oncogene Proteins pp60(c-src), Tumor Cells, Cultured, Ubiquitins, ras Proteins
Added March 11, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Rameh LE, Chen CS, Cantley LC
(1995) Cell 83: 821-30
MeSH Terms: Amino Acid Sequence, Androstadienes, Animals, Binding, Competitive, CHO Cells, Chromones, Cricetinae, Enzyme Inhibitors, Humans, Insulin, Molecular Sequence Data, Morpholines, Phosphatidylinositol 3-Kinases, Phosphatidylinositol Phosphates, Phosphoproteins, Phosphotransferases (Alcohol Group Acceptor), Phosphotyrosine, Proto-Oncogene Proteins pp60(c-src), Receptor, Insulin, Transfection, Wortmannin, src Homology Domains
Added November 26, 2018
0 Communities
1 Members
0 Resources
22 MeSH Terms
Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes.
Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu J, Zhang Z
(1994) Mol Cell Biol 14: 8333-42
MeSH Terms: 3T3 Cells, Alternative Splicing, Amino Acid Sequence, Animals, Antibodies, Monoclonal, Cadherins, Catenins, Cattle, Cell Adhesion Molecules, Cell Line, Cell Transformation, Neoplastic, Cytoskeletal Proteins, Macromolecular Substances, Mice, Molecular Sequence Data, Phosphoproteins, Phosphotyrosine, Protein Binding, Protein-Tyrosine Kinases, Proto-Oncogene Proteins pp60(c-src), Trans-Activators, Tyrosine, beta Catenin
Added March 5, 2014
1 Communities
1 Members
0 Resources
23 MeSH Terms