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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 16

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Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma.
Imielinski M, Greulich H, Kaplan B, Araujo L, Amann J, Horn L, Schiller J, Villalona-Calero MA, Meyerson M, Carbone DP
(2014) J Clin Invest 124: 1582-6
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Aged, Amino Acid Substitution, Antineoplastic Agents, Cell Transformation, Neoplastic, DNA, Neoplasm, Female, Humans, Lung Neoplasms, Molecular Targeted Therapy, Mutation, Missense, Niacinamide, Oncogenes, Phenylurea Compounds, Proto-Oncogene Proteins A-raf, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf, Sorafenib
Added June 26, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE
(2014) J Biol Chem 289: 4219-32
MeSH Terms: Amino Acid Substitution, Animals, Cattle, Cell Line, Extracellular Signal-Regulated MAP Kinases, Glycoproteins, Humans, Multienzyme Complexes, Mutation, Missense, Phosphorylation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins p21(ras), Rats, rac1 GTP-Binding Protein, ras Proteins
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
FAM83B mediates EGFR- and RAS-driven oncogenic transformation.
Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, Jackson MW
(2012) J Clin Invest 122: 3197-210
MeSH Terms: Amino Acid Sequence, Animals, Antineoplastic Agents, Base Sequence, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Drug Resistance, Neoplasm, Epithelial Cells, ErbB Receptors, Erlotinib Hydrochloride, Gene Expression, Gene Knockdown Techniques, Humans, Mammary Glands, Human, Mice, Mice, Inbred NOD, Mice, SCID, Molecular Sequence Data, Neoplasm Proteins, Neoplasm Transplantation, Neoplasms, Oligonucleotide Array Sequence Analysis, Protein Structure, Tertiary, Proto-Oncogene Proteins c-raf, Quinazolines, RNA Interference, Signal Transduction, TOR Serine-Threonine Kinases, Transcriptome, ras Proteins
Added March 21, 2013
0 Communities
1 Members
0 Resources
31 MeSH Terms
The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.
Coffa S, Breitman M, Hanson SM, Callaway K, Kook S, Dalby KN, Gurevich VV
(2011) PLoS One 6: e28723
MeSH Terms: Animals, Arrestin, Arrestins, COS Cells, Cattle, Chlorocebus aethiops, Embryo, Mammalian, Enzyme Activation, Fibroblasts, HEK293 Cells, Humans, Ligands, MAP Kinase Kinase 1, Mice, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mutant Proteins, Phosphorylation, Protein Binding, Protein Conformation, Proto-Oncogene Proteins c-raf, Receptors, Adrenergic, beta-2, Structure-Activity Relationship, beta-Arrestins
Added December 10, 2013
0 Communities
1 Members
0 Resources
25 MeSH Terms
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Steelman LS, McCubrey JA
(2011) Oncotarget 2: 610-26
MeSH Terms: Antibiotics, Antineoplastic, Antineoplastic Agents, Hormonal, Breast Neoplasms, Cell Line, Tumor, Cellular Senescence, Dose-Response Relationship, Drug, Doxorubicin, Drug Resistance, Neoplasm, Female, Humans, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-raf, Signal Transduction, Tamoxifen, Time Factors, Transfection
Added January 20, 2015
0 Communities
1 Members
0 Resources
16 MeSH Terms
A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding.
Coffa S, Breitman M, Spiller BW, Gurevich VV
(2011) Biochemistry 50: 6951-8
MeSH Terms: Arrestins, Blotting, Western, Cell Line, Enzyme Activation, Extracellular Signal-Regulated MAP Kinases, Humans, Immunoprecipitation, Models, Molecular, Mutagenesis, Site-Directed, Protein Binding, Proto-Oncogene Proteins c-raf
Added December 10, 2013
0 Communities
2 Members
0 Resources
11 MeSH Terms
TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.
Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB
(2008) J Biol Chem 283: 29485-94
MeSH Terms: Animals, Apoptosis, Cell Survival, Cells, Cultured, Colon, Epithelial Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, NF-kappa B, Phosphorylation, Proto-Oncogene Proteins c-raf, Receptors, Tumor Necrosis Factor, Type I, Signal Transduction
Added March 20, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms
Constitutive activation of Raf-1 induces glioma formation in mice.
Lyustikman Y, Momota H, Pao W, Holland EC
(2008) Neoplasia 10: 501-10
MeSH Terms: Animals, Animals, Newborn, Blotting, Western, Brain, Brain Neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Genes, ras, Glioblastoma, Humans, Immunoenzyme Techniques, Mice, Mice, Knockout, Mutation, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-raf
Added March 24, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.
Bidzhekov K, Hautmann M, Semisch M, Weber C, Engelmann B, Hatzopoulos AK
(2007) J Cell Mol Med 11: 1395-407
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Cell Separation, Cloning, Molecular, Embryo, Mammalian, Endothelial Cells, Enzyme Activation, Estrogens, Genetic Engineering, Mice, Models, Biological, Phosphorylation, Protein Structure, Tertiary, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-raf, RNA Interference, Receptors, Estrogen, Recombinant Fusion Proteins, Stem Cells
Added November 18, 2010
1 Communities
1 Members
0 Resources
20 MeSH Terms
Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks.
Herzberg K, Bashkirov VI, Rolfsmeier M, Haghnazari E, McDonald WH, Anderson S, Bashkirova EV, Yates JR, Heyer WD
(2006) Mol Cell Biol 26: 8396-409
MeSH Terms: Adenosine Triphosphatases, Amino Acid Sequence, Cell Cycle Proteins, Checkpoint Kinase 2, DNA Damage, DNA Repair, DNA Repair Enzymes, DNA Replication, DNA, Fungal, DNA-Binding Proteins, Gene Expression Regulation, Fungal, Genome, Mass Spectrometry, Models, Genetic, Molecular Sequence Data, Phosphorylation, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-raf, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Serine
Added March 20, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms