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Results: 1 to 10 of 122

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lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network, Xie W, Yang D
(2018) Cancer Cell 33: 706-720.e9
MeSH Terms: Animals, Binding Sites, Breast Neoplasms, Cell Cycle, Cell Line, Tumor, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Neoplasm Transplantation, Prognosis, Promoter Regions, Genetic, Proto-Oncogene Proteins c-myc, RNA, Long Noncoding, Up-Regulation
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
Schaub FX, Dhankani V, Berger AC, Trivedi M, Richardson AB, Shaw R, Zhao W, Zhang X, Ventura A, Liu Y, Ayer DE, Hurlin PJ, Cherniack AD, Eisenman RN, Bernard B, Grandori C, Cancer Genome Atlas Network
(2018) Cell Syst 6: 282-300.e2
MeSH Terms: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Basic Helix-Loop-Helix Transcription Factors, Biomarkers, Tumor, Carcinogenesis, Chromatin, Computational Biology, Genes, myc, Genomics, Humans, Neoplasms, Oncogenes, Proteomics, Proto-Oncogene Proteins c-myc, Repressor Proteins, Signal Transduction, Transcription Factors
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL
(2017) Cell Metab 26: 633-647.e7
MeSH Terms: Animals, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Humans, Mice, Nude, Mitochondria, Myeloid Cell Leukemia Sequence 1 Protein, Neoplastic Stem Cells, Oxidative Phosphorylation, Proto-Oncogene Proteins c-myc, Reactive Oxygen Species, Triple Negative Breast Neoplasms
Added March 14, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS
(2017) Gut 66: 852-862
MeSH Terms: Animals, Biomarkers, Tumor, Caco-2 Cells, Carcinogenesis, Cell Adhesion Molecules, Colitis, Colitis, Ulcerative, Colon, Colonic Neoplasms, DNA Methylation, Dextran Sulfate, Down-Regulation, Female, Gene Expression Profiling, HEK293 Cells, Humans, Male, Membrane Proteins, Mice, Mice, Knockout, Muscle Proteins, Promoter Regions, Genetic, Protein Phosphatase 2, Proto-Oncogene Proteins c-myc, RNA, Messenger, Wnt Signaling Pathway
Added April 15, 2017
0 Communities
4 Members
0 Resources
26 MeSH Terms
Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition.
Moyo TK, Wilson CS, Moore DJ, Eischen CM
(2017) Oncogene 36: 4653-4661
MeSH Terms: Adenine, Agammaglobulinaemia Tyrosine Kinase, Animals, B-Lymphocytes, CD79 Antigens, Cell Proliferation, Flow Cytometry, Humans, Lymphoma, Non-Hodgkin, Male, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase 3, Phosphatidylinositol 3-Kinases, Phospholipase C gamma, Phosphorylation, Piperidines, Precancerous Conditions, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-myc, Pyrazoles, Pyrimidines, Receptors, Antigen, B-Cell, Splenic Neoplasms, Syk Kinase
Added April 6, 2017
0 Communities
1 Members
0 Resources
25 MeSH Terms
c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis.
Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX
(2018) Gut 67: 707-718
MeSH Terms: Acinar Cells, Animals, Cell Differentiation, Disease Models, Animal, Down-Regulation, Homeostasis, Mice, Pancreas, Pancreatic Neoplasms, Proto-Oncogene Proteins c-myc, Transcription Factors
Added February 7, 2017
0 Communities
2 Members
0 Resources
11 MeSH Terms
Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A
(2017) Cancer Cell 31: 142-156
MeSH Terms: Age Factors, Animals, Apoptosis, Doxorubicin, Humans, Mice, Mitochondria, Neoplasms, Organ Specificity, Proto-Oncogene Proteins c-myc, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Added March 26, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo.
Yang S, Jiang M, Grabowska MM, Li J, Connelly ZM, Zhang J, Hayward SW, Cates JM, Han G, Yu X
(2016) Oncotarget 7: 70404-70419
MeSH Terms: Androgens, Animals, Cell Differentiation, Cell Line, Cell Proliferation, Coculture Techniques, Epithelial Cells, Humans, Male, Mice, Nude, Prostate, Proto-Oncogene Proteins c-myc, Rats, Receptors, Androgen, Stromal Cells
Added November 1, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies.
Adams CM, Hiebert SW, Eischen CM
(2016) Cancer Res 76: 736-48
MeSH Terms: Animals, Apoptosis, Cell Line, Tumor, Hematologic Neoplasms, Histone Deacetylase Inhibitors, Humans, Mice, Inbred C57BL, MicroRNAs, Proto-Oncogene Proteins c-myc, Transfection
Added February 4, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms
Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.
Thomas LR, Foshage AM, Weissmiller AM, Popay TM, Grieb BC, Qualls SJ, Ng V, Carboneau B, Lorey S, Eischen CM, Tansey WP
(2016) Oncogene 35: 3613-8
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cell Transformation, Neoplastic, Conserved Sequence, Evolution, Molecular, HEK293 Cells, Host Cell Factor C1, Humans, Immunoprecipitation, Mice, Mutation, NIH 3T3 Cells, Protein Binding, Proto-Oncogene Proteins c-myc, Sequence Homology, Amino Acid
Added March 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms