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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 67

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Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition.
Shattuck-Brandt RL, Chen SC, Murray E, Johnson CA, Crandall H, O'Neal JF, Al-Rohil RN, Nebhan CA, Bharti V, Dahlman KB, Ayers GD, Yan C, Kelley MC, Kauffmann RM, Hooks M, Grau A, Johnson DB, Vilgelm AE, Richmond A
(2020) Clin Cancer Res 26: 3803-3818
MeSH Terms: Adult, Aged, Animals, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Female, Humans, MAP Kinase Signaling System, Male, Melanoma, Mice, Middle Aged, Mitogen-Activated Protein Kinase Kinases, Mutation, Protein Kinase Inhibitors, Proteolysis, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-mdm2, Skin Neoplasms, Tumor Suppressor Protein p53, Ubiquitination, Xenograft Model Antitumor Assays
Added May 4, 2020
0 Communities
1 Members
0 Resources
22 MeSH Terms
MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
Vilgelm AE, Saleh N, Shattuck-Brandt R, Riemenschneider K, Slesur L, Chen SC, Johnson CA, Yang J, Blevins A, Yan C, Johnson DB, Al-Rohil RN, Halilovic E, Kauffmann RM, Kelley M, Ayers GD, Richmond A
(2019) Sci Transl Med 11:
MeSH Terms: Analysis of Variance, Animals, Blotting, Western, Cell Cycle, Cell Survival, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase Inhibitor p21, DNA Replication, Dimethyl Sulfoxide, Humans, Immunoprecipitation, MCF-7 Cells, Melanoma, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Proteomics, Proto-Oncogene Proteins c-mdm2, Radioimmunoprecipitation Assay
Added September 27, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
The proto-oncogene function of Mdm2 in bone.
Olivos DJ, Perrien DS, Hooker A, Cheng YH, Fuchs RK, Hong JM, Bruzzaniti A, Chun K, Eischen CM, Kacena MA, Mayo LD
(2018) J Cell Biochem 119: 8830-8840
MeSH Terms: Analysis of Variance, Animals, Bone Density, Bone Remodeling, Calcification, Physiologic, Cancellous Bone, Cell Line, Tumor, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Osteoblasts, Osteoclasts, Osteogenesis, Osteosarcoma, Proto-Oncogene Mas, Proto-Oncogene Proteins c-mdm2, Proto-Oncogenes
Added April 1, 2019
0 Communities
2 Members
0 Resources
20 MeSH Terms
MDM2 Antagonists Counteract Drug-Induced DNA Damage.
Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A
(2017) EBioMedicine 24: 43-55
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Azepines, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA Damage, DNA Replication, HCT116 Cells, Humans, Imidazoles, Melanoma, Mice, Piperazines, Protein Binding, Proto-Oncogene Proteins c-mdm2, Pyrimidines, Pyrrolidines, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, para-Aminobenzoates
Added June 20, 2018
1 Communities
2 Members
0 Resources
MeSH Terms
Liposarcomatous differentiation in malignant phyllodes tumours is unassociated with MDM2 or CDK4 amplification.
Lyle PL, Bridge JA, Simpson JF, Cates JM, Sanders ME
(2016) Histopathology 68: 1040-5
MeSH Terms: Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Breast Neoplasms, Cell Differentiation, Cyclin-Dependent Kinase 4, Female, Gene Amplification, Humans, In Situ Hybridization, Fluorescence, Liposarcoma, Middle Aged, Nerve Sheath Neoplasms, Phenotype, Phyllodes Tumor, Proto-Oncogene Proteins c-mdm2
Added February 15, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells.
Carrillo AM, Hicks M, Khabele D, Eischen CM
(2015) Mol Cancer Res 13: 1197-205
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Cell Line, Tumor, Cell Proliferation, Cisplatin, Comet Assay, DNA Breaks, Double-Stranded, DNA Damage, DNA Repair, Etoposide, Female, Fibroblasts, HEK293 Cells, Humans, Imidazoles, Mice, Mice, Transgenic, Mutagens, Ovarian Neoplasms, Piperazines, Proto-Oncogene Proteins c-mdm2, Tumor Suppressor Protein p53
Added February 22, 2016
0 Communities
1 Members
0 Resources
23 MeSH Terms
Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway.
Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI
(2015) Oncotarget 6: 1531-43
MeSH Terms: Animals, Cell Line, Tumor, Gerbillinae, Helicobacter Infections, Helicobacter pylori, Humans, MAP Kinase Signaling System, Proto-Oncogene Proteins c-mdm2, Stomach Neoplasms, Transfection, Tumor Suppressor Protein p53
Added February 19, 2015
0 Communities
5 Members
0 Resources
11 MeSH Terms
Bacterial Pathogen Helicobacter pylori: A Bad AKTor Inhibits p53 Protein Activity [corrected].
Zaika AI
(2015) Dig Dis Sci 60: 822-3
MeSH Terms: Female, Gastric Mucosa, Helicobacter Infections, Humans, Male, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-mdm2, Tumor Suppressor Protein p53
Added April 11, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms
Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.
Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A
(2015) Cancer Res 75: 181-93
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Aurora Kinase A, Azepines, Cell Proliferation, Humans, Imidazoles, Melanoma, Melanoma, Experimental, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Piperazines, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-mdm2, Pyrimidines
Added January 20, 2015
2 Communities
4 Members
0 Resources
17 MeSH Terms
Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.
Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM
(2014) Cancer Res 74: 3591-602
MeSH Terms: 3T3 Cells, ATPases Associated with Diverse Cellular Activities, Animals, Apoptosis, Breast Neoplasms, Carrier Proteins, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, DNA Helicases, Female, Gene Dosage, HEK293 Cells, Humans, Mice, Mice, Nude, Protein Binding, Proto-Oncogene Proteins c-mdm2, Proto-Oncogene Proteins c-myc, Rats
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms