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Results: 1 to 10 of 44

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Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin.
Maddur AA, Kroh HK, Aschenbrenner ME, Gibson BHY, Panizzi P, Sheehan JH, Meiler J, Bock PE, Verhamme IM
(2020) J Biol Chem 295: 5614-5625
MeSH Terms: Bacterial Proteins, Binding Sites, Coagulase, Humans, Models, Molecular, Protein Binding, Prothrombin, Staphylococcal Infections, Staphylococcus aureus, Substrate Specificity
Added March 21, 2020
0 Communities
1 Members
0 Resources
10 MeSH Terms
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.
Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ
(2013) J Thromb Haemost 11: 1341-52
MeSH Terms: Animals, Antibodies, Neutralizing, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XIIa, Factor XIa, Humans, Plant Proteins, Polyphosphates, Prothrombin, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.
Kroh HK, Bock PE
(2012) J Biol Chem 287: 39149-57
MeSH Terms: Binding, Competitive, Blood Coagulation, Carrier Proteins, Catalytic Domain, Enzyme Precursors, Fibrin, HEK293 Cells, Humans, Kinetics, Platelet Membrane Glycoproteins, Protein Binding, Protein Conformation, Protein Structure, Tertiary, Prothrombin, Recombinant Proteins, Staphylococcus aureus, Thermodynamics, Thrombin, Virulence Factors, von Willebrand Factor
Added January 20, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
New serum markers of hepatocellular carcinoma.
Masuzaki R, Karp SJ, Omata M
(2012) Semin Oncol 39: 434-9
MeSH Terms: Biomarkers, Biomarkers, Tumor, Carcinoma, Hepatocellular, Glypicans, Hepatocyte Growth Factor, Humans, Insulin-Like Growth Factor I, Liver Neoplasms, Osteopontin, Protein Precursors, Prothrombin, Vascular Endothelial Growth Factor A, alpha-Fetoproteins
Added May 2, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Persistent hypocoagulability in patients with septic shock predicts greater hospital mortality: impact of impaired thrombin generation.
Massion PB, Peters P, Ledoux D, Zimermann V, Canivet JL, Massion PP, Damas P, Gothot A
(2012) Intensive Care Med 38: 1326-35
MeSH Terms: Aged, Anticoagulants, Antithrombin III, Blood Coagulation Disorders, Blood Coagulation Factors, Female, Fibrin, Hospital Mortality, Humans, Intensive Care Units, Logistic Models, Longitudinal Studies, Male, Middle Aged, Partial Thromboplastin Time, Prospective Studies, Protein C, Prothrombin Time, Shock, Septic, Thrombin
Added March 10, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence.
Soroida Y, Ohkawa R, Nakagawa H, Satoh Y, Yoshida H, Kinoshita H, Tateishi R, Masuzaki R, Enooku K, Shiina S, Sato T, Obi S, Hoshino T, Nagatomo R, Okubo S, Yokota H, Koike K, Yatomi Y, Ikeda H
(2012) J Hepatol 57: 330-6
MeSH Terms: Aged, Biomarkers, Carcinoma, Hepatocellular, Creatine Kinase, Mitochondrial Form, Female, Humans, Isoenzymes, Liver Neoplasms, Male, Middle Aged, Neoplasm Recurrence, Local, Protein Precursors, Prothrombin, RNA, Messenger, alpha-Fetoproteins
Added May 2, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors.
Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Sato T, Masuzaki R, Kondo Y, Goto T, Yoshida H, Omata M, Koike K
(2012) Am J Gastroenterol 107: 569-77; quiz 578
MeSH Terms: Aged, Biomarkers, Biomarkers, Tumor, Carcinoma, Hepatocellular, Catheter Ablation, Disease Progression, Female, Follow-Up Studies, Humans, Lectins, Liver Neoplasms, Male, Multivariate Analysis, Neoplasm Recurrence, Local, Neoplasm Staging, Prognosis, Prospective Studies, Protein Precursors, Prothrombin, Reoperation, Risk Factors, Survival Rate, Tomography, X-Ray Computed, Treatment Outcome, alpha-Fetoproteins
Added May 2, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times.
Enooku K, Tateishi R, Kanai F, Kondo Y, Masuzaki R, Goto T, Shiina S, Yoshida H, Omata M, Koike K
(2012) J Gastroenterol 47: 71-8
MeSH Terms: Aged, Antineoplastic Agents, Biomarkers, Biomarkers, Tumor, Carcinoma, Hepatocellular, Disease Progression, Female, Humans, Indoles, Liver Neoplasms, Male, Middle Aged, Molecular Targeted Therapy, Oxindoles, Propionates, Protein Kinase Inhibitors, Protein Precursors, Prothrombin, Pyrroles, Time Factors, Treatment Outcome, Tumor Burden, alpha-Fetoproteins
Added May 2, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.
Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R
(2011) Nat Med 17: 1142-6
MeSH Terms: Animals, Coagulase, Endocarditis, Bacterial, Mice, Microscopy, Fluorescence, Positron-Emission Tomography, Protein Engineering, Prothrombin, Quorum Sensing, Staphylococcus aureus
Added January 20, 2015
0 Communities
1 Members
0 Resources
10 MeSH Terms
Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.
Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE
(2011) J Biol Chem 286: 23345-56
MeSH Terms: Amino Acid Substitution, Animals, Blood Coagulation, Catalytic Domain, Enzyme Activation, Humans, Kinetics, Mice, Mutation, Missense, Protein Structure, Tertiary, Prothrombin, Thromboplastin, Thrombosis
Added January 20, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms