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Results: 1 to 10 of 75

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Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.
Dear ML, Shilts J, Broadie K
(2017) Sci Signal 10:
MeSH Terms: Animals, Disease Models, Animal, Drosophila Proteins, Drosophila melanogaster, Fragile X Syndrome, Heparan Sulfate Proteoglycans, Matrix Metalloproteinase 1, Matrix Metalloproteinase 2, Neuromuscular Junction, Neurons, Presynaptic Terminals, Proteoglycans, Wnt Signaling Pathway
Added December 7, 2017
1 Communities
0 Members
0 Resources
13 MeSH Terms
Functional defects in TcdB toxin uptake identify CSPG4 receptor-binding determinants.
Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA
(2017) J Biol Chem 292: 17290-17301
MeSH Terms: Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Bacterial Proteins, Bacterial Toxins, Broadly Neutralizing Antibodies, CHO Cells, Caco-2 Cells, Chlorocebus aethiops, Chondroitin Sulfate Proteoglycans, Clostridioides difficile, Cricetinae, Cricetulus, Glucosyltransferases, HEK293 Cells, Humans, Membrane Proteins, Protein Binding, Protein Domains
Added April 3, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Rare and low-frequency coding variants alter human adult height.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NG, Ng MC, Mudgal P, Rivas MA, Vedantam S, Mahajan A, Guo X, Abecasis G, Aben KK, Adair LS, Alam DS, Albrecht E, Allin KH, Allison M, Amouyel P, Appel EV, Arveiler D, Asselbergs FW, Auer PL, Balkau B, Banas B, Bang LE, Benn M, Bergmann S, Bielak LF, Blüher M, Boeing H, Boerwinkle E, Böger CA, Bonnycastle LL, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Burt AA, Butterworth AS, Carey DJ, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Galbany JC, Cox AJ, Cuellar-Partida G, Danesh J, Davies G, de Bakker PI, de Borst GJ, de Denus S, de Groot MC, de Mutsert R, Deary IJ, Dedoussis G, Demerath EW, den Hollander AI, Dennis JG, Di Angelantonio E, Drenos F, Du M, Dunning AM, Easton DF, Ebeling T, Edwards TL, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Faul JD, Feitosa MF, Feng S, Ferrannini E, Ferrario MM, Ferrieres J, Florez JC, Ford I, Fornage M, Franks PW, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Giedraitis V, Giri A, Girotto G, Gordon SD, Gordon-Larsen P, Gorski M, Grarup N, Grove ML, Gudnason V, Gustafsson S, Hansen T, Harris KM, Harris TB, Hattersley AT, Hayward C, He L, Heid IM, Heikkilä K, Helgeland Ø, Hernesniemi J, Hewitt AW, Hocking LJ, Hollensted M, Holmen OL, Hovingh GK, Howson JM, Hoyng CB, Huang PL, Hveem K, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jhun MA, Jia Y, Jiang X, Johansson S, Jørgensen ME, Jørgensen T, Jousilahti P, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SL, Karpe F, Kee F, Keeman R, Kiemeney LA, Kitajima H, Kluivers KB, Kocher T, Komulainen P, Kontto J, Kooner JS, Kooperberg C, Kovacs P, Kriebel J, Kuivaniemi H, Küry S, Kuusisto J, La Bianca M, Laakso M, Lakka TA, Lange EM, Lange LA, Langefeld CD, Langenberg C, Larson EB, Lee IT, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu Y, Liu Y, Lophatananon A, Luan J, Lubitz SA, Lyytikäinen LP, Mackey DA, Madden PA, Manning AK, Männistö S, Marenne G, Marten J, Martin NG, Mazul AL, Meidtner K, Metspalu A, Mitchell P, Mohlke KL, Mook-Kanamori DO, Morgan A, Morris AD, Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Nauck M, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Ntalla I, O'Connel JR, Oksa H, Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CN, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JR, Person TN, Pirie A, Polasek O, Posthuma D, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Ridker PM, Rioux JD, Robertson N, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sandow K, Sapkota Y, Sattar N, Schmidt MK, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah S, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith JA, Southam L, Spector TD, Speliotes EK, Starr JM, Steinthorsdottir V, Stringham HM, Stumvoll M, Surendran P, 't Hart LM, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Ulivi S, van der Laan SW, Van Der Leij AR, van Duijn CM, van Schoor NM, van Setten J, Varbo A, Varga TV, Varma R, Edwards DR, Vermeulen SH, Vestergaard H, Vitart V, Vogt TF, Vozzi D, Walker M, Wang F, Wang CA, Wang S, Wang Y, Wareham NJ, Warren HR, Wessel J, Willems SM, Wilson JG, Witte DR, Woods MO, Wu Y, Yaghootkar H, Yao J, Yao P, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zheng H, Zhou W, EPIC-InterAct Consortium, CHD Exome+ Consortium, ExomeBP Consortium, T2D-Genes Consortium, GoT2D Genes Consortium, Global Lipids Genetics Consortium, ReproGen Consortium, MAGIC Investigators, Rotter JI, Boehnke M, Kathiresan S, McCarthy MI, Willer CJ, Stefansson K, Borecki IB, Liu DJ, North KE, Heard-Costa NL, Pers TH, Lindgren CM, Oxvig C, Kutalik Z, Rivadeneira F, Loos RJ, Frayling TM, Hirschhorn JN, Deloukas P, Lettre G
(2017) Nature 542: 186-190
MeSH Terms: ADAMTS Proteins, Adult, Alleles, Body Height, Cell Adhesion Molecules, Female, Gene Frequency, Genetic Variation, Genome, Human, Glycoproteins, Glycosaminoglycans, Hedgehog Proteins, Humans, Intercellular Signaling Peptides and Proteins, Interferon Regulatory Factors, Interleukin-11 Receptor alpha Subunit, Male, Multifactorial Inheritance, NADPH Oxidase 4, NADPH Oxidases, Phenotype, Pregnancy-Associated Plasma Protein-A, Procollagen N-Endopeptidase, Proteoglycans, Proteolysis, Receptors, Androgen, Somatomedins
Added April 26, 2017
0 Communities
1 Members
0 Resources
27 MeSH Terms
The nature and biology of basement membranes.
Pozzi A, Yurchenco PD, Iozzo RV
(2017) Matrix Biol 57-58: 1-11
MeSH Terms: Agrin, Animals, Basement Membrane, Bone Diseases, Developmental, Collagen Type IV, Diabetic Nephropathies, Extracellular Matrix, Gene Expression Regulation, Heparan Sulfate Proteoglycans, Humans, Laminin, Lupus Nephritis, Mechanotransduction, Cellular, Membrane Glycoproteins, Mutation, Protein Isoforms
Added March 26, 2017
0 Communities
0 Members
1 Resources
16 MeSH Terms
Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis.
Dear ML, Dani N, Parkinson W, Zhou S, Broadie K
(2016) Development 143: 75-87
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Cell Communication, Drosophila, Drosophila Proteins, Frizzled Receptors, Heparan Sulfate Proteoglycans, Matrix Metalloproteinase 1, Matrix Metalloproteinase 2, Neurogenesis, Neuromuscular Junction, Nuclear Proteins, Synapses, Tissue Inhibitor of Metalloproteinases, Wnt Signaling Pathway, Wnt1 Protein
Added March 29, 2017
1 Communities
1 Members
0 Resources
16 MeSH Terms
Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel JE, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC
(2015) Circ Res 117: 995-1000
MeSH Terms: Cell Differentiation, Cells, Cultured, Collagen, Drug Combinations, Humans, Induced Pluripotent Stem Cells, Laminin, Myocardial Contraction, Myocytes, Cardiac, Pluripotent Stem Cells, Proteoglycans
Added October 4, 2015
1 Communities
2 Members
0 Resources
11 MeSH Terms
Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
Oskarsson ME, Singh K, Wang J, Vlodavsky I, Li JP, Westermark GT
(2015) J Biol Chem 290: 15121-32
MeSH Terms: Amyloid, Animals, Apoptosis, Base Sequence, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, DNA Primers, Glucuronidase, Heparan Sulfate Proteoglycans, Humans, Islet Amyloid Polypeptide, Islets of Langerhans, Mice, Mice, Inbred C57BL, Mice, Transgenic, Real-Time Polymerase Chain Reaction
Added June 6, 2017
1 Communities
0 Members
0 Resources
18 MeSH Terms
Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motility.
Allison P, Espiritu D, Barnett JV, Camenisch TD
(2015) Cell Signal 27: 453-9
MeSH Terms: Actin Cytoskeleton, Amino Acid Substitution, Animals, Arrestin, Cell Movement, Cells, Cultured, Epithelial-Mesenchymal Transition, Hyaluronic Acid, Mice, Neuropeptides, Pericardium, Protein Binding, Proteoglycans, RNA Interference, RNA, Small Interfering, Receptors, Transforming Growth Factor beta, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, src-Family Kinases
Added February 21, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
Coles CH, Mitakidis N, Zhang P, Elegheert J, Lu W, Stoker AW, Nakagawa T, Craig AM, Jones EY, Aricescu AR
(2014) Nat Commun 5: 5209
MeSH Terms: Animals, Cell Differentiation, Chick Embryo, Coculture Techniques, Crystallization, Extracellular Matrix Proteins, Humans, Ligands, Mice, Neurogenesis, Neurons, Protein Binding, Protein Structure, Tertiary, Proteoglycans, Receptor, trkC, Receptor-Like Protein Tyrosine Phosphatases, Class 2, Signal Transduction, Synapses
Added February 2, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL
(2015) Dev Dyn 244: 122-33
MeSH Terms: Animals, Antigens, Differentiation, Calcification, Physiologic, Gene Expression Regulation, Developmental, Mesoderm, Mice, Mice, Knockout, Neovascularization, Physiologic, Organogenesis, Osteoblasts, Palate, Hard, Proteoglycans, Receptors, Transforming Growth Factor beta
Added February 19, 2015
0 Communities
2 Members
0 Resources
13 MeSH Terms