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AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
Kamalova A, Futai K, Delpire E, Nakagawa T
(2020) Cell Rep 32: 107921
MeSH Terms: Animals, Cerebral Cortex, Claudins, Disease Susceptibility, Mice, Knockout, Neuronal Plasticity, Neurons, Protein Subunits, Seizures, Synapses, Thalamus
Added July 28, 2020
1 Communities
0 Members
0 Resources
11 MeSH Terms
AMPA receptor structure and auxiliary subunits.
Kamalova A, Nakagawa T
(2021) J Physiol 599: 453-469
MeSH Terms: Animals, Glutamic Acid, Ion Channel Gating, Protein Subunits, Receptors, AMPA, Synapses, Synaptic Transmission
Added March 3, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms
Maturation of the respiratory complex II flavoprotein.
Sharma P, Maklashina E, Cecchini G, Iverson TM
(2019) Curr Opin Struct Biol 59: 38-46
MeSH Terms: Animals, Cell Respiration, Electron Transport Chain Complex Proteins, Electron Transport Complex II, Flavin-Adenine Dinucleotide, Flavoproteins, Humans, Protein Binding, Protein Subunits, Structure-Activity Relationship
Added April 1, 2019
0 Communities
1 Members
0 Resources
10 MeSH Terms
Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study.
Salisbury-Ruf CT, Bertram CC, Vergeade A, Lark DS, Shi Q, Heberling ML, Fortune NL, Okoye GD, Jerome WG, Wells QS, Fessel J, Moslehi J, Chen H, Roberts LJ, Boutaud O, Gamazon ER, Zinkel SS
(2018) Elife 7:
MeSH Terms: Animals, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Beclin-1, Cell Respiration, Fibrosis, Gene Expression Regulation, Genome-Wide Association Study, Genomics, Heart Diseases, Heart Ventricles, Humans, Mice, Inbred C57BL, Mitochondria, Mitochondrial Proton-Translocating ATPases, Mutation, Myeloid Progenitor Cells, Myocardial Infarction, Myocytes, Cardiac, Polymorphism, Single Nucleotide, Protein Multimerization, Protein Structure, Secondary, Protein Subunits, Reactive Oxygen Species, Reproducibility of Results, Up-Regulation
Added December 11, 2018
0 Communities
4 Members
0 Resources
26 MeSH Terms
The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS.
Maklashina E, Rajagukguk S, Iverson TM, Cecchini G
(2018) J Biol Chem 293: 7754-7765
MeSH Terms: Bacterial Proteins, Catalysis, Crystallography, X-Ray, Electron Transport Complex II, Escherichia coli, Flavoproteins, Humans, Models, Molecular, Oxidation-Reduction, Protein Conformation, Protein Subunits, Reactive Oxygen Species
Added April 1, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.
Lyman KA, Han Y, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM
(2017) J Biol Chem 292: 17718-17730
MeSH Terms: Allosteric Regulation, Binding Sites, HEK293 Cells, Humans, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Protein Subunits, Receptors, Cytoplasmic and Nuclear
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Building collagen IV smart scaffolds on the outside of cells.
Brown KL, Cummings CF, Vanacore RM, Hudson BG
(2017) Protein Sci 26: 2151-2161
MeSH Terms: Amino Acid Motifs, Amino Acid Oxidoreductases, Animals, Antigens, Neoplasm, Basement Membrane, Collagen Type IV, Eukaryotic Cells, Extracellular Matrix, Gene Expression Regulation, Humans, Peroxidases, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Structure, Secondary, Protein Subunits, Receptors, Interleukin-1
Added November 2, 2017
1 Communities
1 Members
0 Resources
16 MeSH Terms
Structural and biochemical analyses reveal insights into covalent flavinylation of the Complex II homolog quinol:fumarate reductase.
Starbird CA, Maklashina E, Sharma P, Qualls-Histed S, Cecchini G, Iverson TM
(2017) J Biol Chem 292: 12921-12933
MeSH Terms: Amino Acid Substitution, Biocatalysis, Crystallography, X-Ray, Enzyme Stability, Escherichia coli, Escherichia coli Proteins, Flavin-Adenine Dinucleotide, Gene Deletion, Glutamic Acid, Hot Temperature, Models, Molecular, Molecular Docking Simulation, Mutagenesis, Site-Directed, Mutation, Oxidoreductases, Protein Conformation, Protein Denaturation, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Processing, Post-Translational, Protein Subunits, Recombinant Proteins, Structural Homology, Protein, Succinate Dehydrogenase
Added April 1, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2 Dravet syndrome mice.
Huang X, Zhou C, Tian M, Kang JQ, Shen W, Verdier K, Pimenta A, MacDonald RL
(2017) Epilepsia 58: 1451-1461
MeSH Terms: Action Potentials, Animals, Convulsants, Electric Stimulation, Epilepsies, Myoclonic, Humans, In Vitro Techniques, Inhibitory Postsynaptic Potentials, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Neural Pathways, Patch-Clamp Techniques, Pentylenetetrazole, Protein Subunits, Pyramidal Cells, Receptors, GABA-A, Somatosensory Cortex, Thalamus
Added June 21, 2017
1 Communities
0 Members
0 Resources
21 MeSH Terms
Reduced ethanol drinking following selective cortical interneuron deletion of the GluN2B NMDA receptors subunit.
Radke AK, Jury NJ, Delpire E, Nakazawa K, Holmes A
(2017) Alcohol 58: 47-51
MeSH Terms: Alcohol Drinking, Animals, Cerebral Cortex, Choice Behavior, Ethanol, Female, Gene Deletion, Interneurons, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Protein Subunits, Receptors, N-Methyl-D-Aspartate
Added May 3, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms